Mathurin Dorel

And now they are about to reach the pinnacle for biology with full length protein with PTMs.
I see a future where every "mass spec" facility runs a Promethion and it is glorious.

I would say it went to where we are today, but some ideas take longer to reach reality than others.

I think ONT's strategy was and still is the correct one: start easy with DNA (stable, 4 letters to discriminate, massive application in diagnostic) and climb up the value chain.

Wait, so ONT demonstrated that they solved protein nanopore sequencing, including three PTMs, on peptides with a few zeptomolar accuracy (1e-21 !, 6 molecules/mL) almost a year ago (finally catching up London calling 2025) and no-one made a big deal out of it ??

This is actually insane.

Very interesting read, making the important distinction between software dev and data analysis workflows. Data analysis is more iterative than software dev because you mostly don't know what the final state of the analysis should look. Iteration is key.

Will definitely try the positron databot.

My First Look at Claude Code Not behind, but at the forefront: On feeling overwhelmed by AI progress, and why that means you're exactly where you need to be.

My First Look at Claude Code blog.stephenturner.us/p/claude-cod...

Did some of the perpetrator's name fail to be redacted as well or did the DOJ work with proper diligence for those ?

Treatment of a teenager with an ultra-rare condition is a medical milestone It will change regulators’ rule books

EXCLUSIVE: A quiet revolution happened at Great Ormond Street Hospital last week. A girl with a rare fatal condition received a custom drug under a new MHRA protcol that is 1st step towards process approval, a shift that could one day save millions of lives. www.economist.com/science-and-...

👇👇👇👇

good piece with an incidental insanely brutal takedown of klein

Anyone with non existing reference in their paper should get publicly named and shamed, and barked from any scientific role forever.
The continuity of knowledge is too important, we have to be able to trace the source of scientific claims.

Our job is to engage with, build upon, & further the academic literature! If you don’t take that responsibility seriously, feel free to find a better-paying job that you’ll be better at.

4-panel vertical comic. (1) 100 Years Ago [two people standing next to bicycle with small car nearby] PERSON 1: It’s too dangerous riding a bike with these cars around. I should get a car, too. (2) 50 Years Ago [two people between smaller car and bigger car] PERSON 2 with short hair: Small cars are less safe in collisions with larger vehicles, so I should get a bigger one. (3) Today [two people between big car and even bigger car] PERSON 1: Everyone has huge SUVs now. If I don’t get the biggest one, I’m putting my family at risk. (4) Soon [two people next to large armored car with spiked clubs attached] PERSON 2: If I don’t install more whirling spike clubs, I’ll be destroyed by all the other drivers who...

Car Size

xkcd.com/3167/

You are under no obligation to mourn the death of people who would’ve celebrated yours.

It's not totally impossible with everything they throw at the cancer and the Russians' expertise in virology.
I'm curious about the side effects though, no way they could dose every cancer patients repeatedly with 4 viruses.
Then comes the question of patient inclusion and mRNA manufacturing.

Cancer Vaccine - biotech solutions in the fight against cancer diseases Oncolytic and personalized vaccines - clinical trials and patient enrollment for Phase I begins as early as late 2024, early 2025

Anyone knows more about the new Russian cancer vaccine ?
The most reliable info I could find in English is that it's 4 viruses. The new press releases also sound like the full treatment involves personalized mRNA and that it was tested in 48 patients with 100% success
new.nmicr.ru/en/pacientam...

Yeah, LLM suck at data retrieval...
(Tried to be lazy today)

Please delete.
This lazy AI crap should not be encouraged. This dumbass could not even be bothered with getting actual pictures of all European leaders for this collage when then each have dozens of official portraits.

Je m’arrête là dessus un instant, car je vois souvent cette étude citée pour dire qu’en gros le recours à la clim augmenterait systématiquement la température de la ville de 2 à 3°C et que c’est bien la preuve que c’est pas une solution.
Ce qui est complètement partiel et trompeur.

No, you did not give those of us who happened to look like the people who bombed Pearl Harbor any due process. And that was profoundly wrong. It destroyed our lives.

Great model for both science and the journals viability.
Everyone just need to convince philanthropists to fund their favorite journals and everybody wins.

The strain on scientific publishing Abstract. Scientists are increasingly overwhelmed by the volume of articles being published. The total number of articles indexed in Scopus and Web of Science has grown exponentially in recent years; ...

If I could change one thing about #ScientificPublishing I'd ask funding bodies to stipulate all work they fund be published in non-profit journals.

The knock-on effects would alleviate most of the strain on #AcademicSky.

This isn't hard. It's big, but actually, it's pretty easy.

1/n

International Positions - HigherEdJobs Jobs in higher education. Faculty and administrative positions at colleges and universities. Updated daily. Free to job seekers.

For Europe at least. USA, Canada and Asia seem better represented at www.higheredjobs.com/international/ and www.higheredjobs.com/international/
But basically looking for "academic job board" should provide the outcome you're looking for.

Find jobs - Academic Positions Career network for academics, researchers and scientists. Find and apply for jobs in research and higher education today!

Actually academicpositions.com does a very good job no?

Notions is great for organisational data aggregation but it's too heavy for note taking.
Great for collaboration though, and you can easily copy-paste the important notes from obsidian.

Obsidians is great for simple formatted text with links. The simplicity and lightness makes it perfect to take note on the phone.
I use it for all my notes now and I've come back to them multiple times thanks to the search function. Tags are great to link topics years appart. And I love the graph.

Starter packs are not the right tools for that, too centralized and not flexible enough.
This should be a community actualized website, or a smart webscrapper that tracks where it finds offers and removes them when they're gone.

Solar is great to power AC during heat waves when managed efficiently (and there also batteries would help). For everything else it's trash that jiggles electrons when they don't need jiggling and needs to be curtained because it's not economically viable.
Cheap to install but worthless production.

But if falls to less than 5% in winter, when Europe needs the most electricity.
Notice on the left graph how wind, *gas* and *coal* take over.
Europe needs to scale up nuclear and batteries big time, for the climate and for it's energy independence. (Hydro scale up is not possible sadly).

La #ScienceTailleXXelles revient en lle-de-France ! 🤩
Nos 21 nouvelles ambassadrices sont mécatronicienne, archéobotaniste, exobiologiste, ou encore informaticienne👩‍🔬
Chercheuses, doctorantes, ingénieures et techniciennes, toutes ont à cœur de montrer que la science se conjugue aussi au féminin !
⤵️

Thermal imaging of a kitchen window. Temperature readings indicate 34.6C at the surface of the window and 29.6C for the wall.

Thermal imaging of a fridge. Temperature reads 29.3C on the front and 35.8C on the side.

Thermal imaging of a towel on drying rack in front of a window. Temperature reads 28.6C for the floor, 25.8C for the towel and 30.6C for the window.

Nice thing about having a thermal camera on your phone is that you can quantify your suffering during a heat wave.
You can also check if your insulation measures are working and how much worse it could get which is nice I guess.