Emilie Brasset

🌱 🚨Postdoc position – Plant Chromatin Biology (Strasbourg)
Grob and Jullien Lab - details attached
📅 Apply by March 30, 2026
📩 stefan.grob@cnrs.fr
Please share with anyone who might be interested!
#Postdoc #PlantScience #Epigenetics #Chromatin

Flyer for symposium: https://ctrlepiedit.sciencesconf.org/

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

Open positions - MuSkLE First competitive call open! The first competitive call in the frame of the MuSkLE programme, which aims at selecting 17 doctoral fellows, opens on 6th March 2026 and closes on 6th May 2026. The open ...

📢 PhD position in our lab! (MSCA COFUND)
About dystrophin in Drosophila muscle progenitor cells 🧬🪰
#PhDPosition #DevBio #Drosophila #StemCells
For candidates from outside France or have lived in France <12 months in the last 3 years.
More info 👇 (Project #16)
www.muskle.eu/recruitment/

COVID’s origins: what we do and don’t know Researchers summarize key insights from the world’s first comprehensive investigation into how a pandemic started.

www.nature.com/articles/d41...

The (Yoav) Voichek lab has opened its gates at the Weizmann Institute, and is actively recruiting students and researchers at all levels - come explore gene regulation and computational genomics in a fun, friendly sprouting lab 🤗🥼⚗️🧪
www.weizmann.ac.il/plants/voichek

We were all very sad to learn the death of Pierre Capy. Pierre was a professor at University Paris Saclay, in the 1990s, he started a group working on the evolutionary genomics of transposable elements; this group is still very active today. He was a great teacher, mentor, and colleague.

Pierre Capy était un généticien, un drosophiliste, un acteur majeur dans l'essor de la génétique des éléments transposables en France.
Très impliqué dans l'administration de la vie scientifique, il a aussi été directeur du laboratoire LEGS (actuel @EGCE), et un des fondateurs en 2016 de @IDEEV.

Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons Abstract. Heterochromatin is characterized by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However,

New paper from my lab out in NAR. We found that young L1 elements are controlled by SETDB1 and H3K9me3 in human neural progenitor cells via a mechanism independent of HUSH and TRIM28/KZNFs.

academic.oup.com/nar/article/...

Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system Transposable elements (TEs) make up about half of the human and mouse genomes and play important regulatory roles in immune responses. However, the cis -regulatory contribution of TEs to immune cell d...

New Year, New Paper!🎊

Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
www.biorxiv.org/content/10.6...

Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵

Dear #Drosophila researchers, the year starts with good news! The date and venue for our next meeting is confirmed: June 1st to 3rd at the beautiful Historic Hotel Castle De Palmela in Portugal! Mark the dates, registration will open soon!

Such a #PLEASURE to be involved in this collaboration ! All the #transposon annotated during the project can be visualized in #RepetDB the TE database.
#TEsky

Systematic analysis of noncanonical ribosomal protein paralogs does not provide evidence for specialized functions in Drosophila

So excited to finally be able to share my first paper and the culmination of my PhD work with @felipekteixeira.bsky.social 🪰🔬

www.pnas.org/doi/10.1073/...

Wow, huge congratulations on your ERC Consolidator @leandroquadrana.bsky.social!Truly well-deserved, I’m really happy for you! www.insb.cnrs.fr/fr/personne/...

Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches
May 18-22, 2026 Roscoff, France
Abstract deadline: January 31, 2026
Apply here: cjm.sb-roscoff.fr/en

JASPAR 2026 is out 🎉

The new release massively expands the TF motif collections and adds a dedicated DeepLearning collection of motifs learned from deep learning models.

Database: jaspar.elixir.no
Paper (NAR): doi.org/10.1093/nar/...

🧵1/2

We are excited to share our new preprint:

SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.

www.biorxiv.org/content/10.64898/2025.12.01.691499v1

Top left: Slbo in the outer border cell non- cell autonomously regulates JNK signaling to maintain the proper apical–basal polarity of the migrating border cell cluster. The proper polarity of the border cell cluster facilitates the formation of the polar cell protrusion at stage 13. Bottom left: After formation of the polar cell protrusion, JNK signaling in the polar cell regulates the movement of lysosomal components towards the oocyte through the nanotube. is deposited at the tip of the protrusion which aids to open the vitelline envelope for sperm entry during fertilization. Right: High-resolution 2D STED imaging (30 nm XY resolution) of a Stage 13 Drosophila egg chamber reveals lysosomal dynamics within a polar-cell nanotube. The polar-cell protrusion is labelled with Fas III (Magenta), nuclei are stained with DAPI (Blue), and lysosomal compartments are visualized using LAMP1-eGFP (Green), which are enriched at the apical side of the polar cell and are also present within the protrusion, indicating active trafficking through the nanotube. Images were acquired with a 60× objective on an ABBERIOR 3D-STED Facility Line microscope.

Membrane #nanotubes are cytoskeletal structures that facilitate intercellular communication. This study shows that polar cell-derived #microtubule nanotubes play a role in #Drosophila #fertilization, creating a channel in the eggshell that facilitates #sperm entry @plosbiology.org 🧪 plos.io/3XwOlvS

The human endogenous retroviral envelope HEMO protein interacts with BACE2: Novel partnership acquired in the primate lineage - PubMed Endogenous retroviruses (ERV) represent 8 to 10% of mammalian genome. While most ERV are defective, a few retroviral genes, such as the envelope syncytins, were exapted during evolution and likely contributed to the emergence of placental mammals. We have previously identified the oldest full-length …

pubmed.ncbi.nlm.nih.gov/41329733/

The human endogenous retroviral envelope HEMO protein interacts with BACE2: Novel partnership acquired in the primate lineage - PubMed Endogenous retroviruses (ERV) represent 8 to 10% of mammalian genome. While most ERV are defective, a few retroviral genes, such as the envelope syncytins, were exapted during evolution and likely contributed to the emergence of placental mammals. We have previously identified the oldest full-length …

Another envelope protein in the human genome. Expressed in the placenta, of course.

And here is the link to access the whole pdf. Enjoy!

I strongly believe that focusing on information & computation during Development provides an important framework, that encapsulates the genetic, chemistry & mechanics, but focusses on organisation, dynamics & logic.
PDF: tinyurl.com/4hn34t8w

An open webinar on our reproducibility project 'WHAT 400 DROSOPHILA PAPERS Teach Us about Doing Better Science' on December 9th 2PM EEST time (1PM Swiss time). Registration below

The tiny germline chromosomes of Paramecium aurelia have an exceptionally high recombination rate and are capped by a new class of Helitrons Background. Paramecia belong to the ciliate phylum of unicellular eukaryotes characterized by nuclear dimorphism. A diploid germline micronucleus (MIC) transmits genetic information across sexual gene...

Excited to share our new preprint on BioRxiv!
A collaborative effort spanning many years and several labs to uncover what the germline chromosomes of Paramecium really look like. 🔗 www.biorxiv.org/content/10.1...
1/5

Our lab is actively looking for posdocs and there is NOW an Open Call for Postdoc contracts (3 years) here: www.aei.gob.es/en/announcem...

Fluorescent protein and peptide tags alter condensate formation and dynamics in vivo and in vitro | EMBO reports imageimageProtein and peptide tags can profoundly alter condensation in a tag- and protein-specific manner, both in cells and in vitro, highlighting the need for careful validation in condensate studi...

www.embopress.org/doi/full/10....

anybody looking for exciting opportunities in RNA research, with the goal to use and learn state of the art thinking and experimenting: here is a good starting point. Ulrich is an outstanding scientist and natural leader.
👇👇👇👇

Excited to share our new @narjournal.bsky.social paper!

Using ReLo and AlphaFold, we described a network of interactions between Drosophila piRNA pathway factors suggesting new links how they coordinate to ensure transposon silencing and genome integrity.

academic.oup.com/nar/article/...

Transposon Regulation in the Caenorhabditis elegans Germline and Soma Transposons are parasitic nucleic acids present in most genomes. The ability of transposons to mobilize makes them a source of genetic diversity and a threat to genome integrity. Interestingly, mutati...

Transposon Regulation in the Caenorhabditis elegans Germline and Soma

www.biorxiv.org/content/10.1...

Congratulations to Magnus Nordborg of the GMI and @oeaw.bsky.social who, together with Leandro Quadrana and @pierrebaduel.bsky.social, has received an @fwf-at.bsky.social Grant for the project “Genetic and epigenetic determinants of transposon dynamics”.

More here: www.oeaw.ac.at/gmi/detail/n...

The virulence gene ToxB is both amplified and disrupted by transposons in the wheat pathogen Pyrenophora tritici-repentis ### Competing Interest Statement The authors have declared no competing interest. Agriculture and Agri-Food Canada, https://ror.org/051dzs374 Alberta Grain Saskatchewan Wheat Development Commissio...

Our latest pre-print on TE-mediated tandem duplication of the ToxB effector is now online...still a puzzle for us but we think it is in a Helitron! Together with amazing collaborators, Reem Aboukhaddour and Ryan Gourlie #TE #fungi
www.biorxiv.org/content/10.1...

piRNA-directed DNA methylation may not be a mammalian invention, but can already be found in the germline of axolotl salamanders
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....