www.findaphd.com/phds/project...
@nebiolabs.bsky.social
@multidefence.bsky.social
08.11.2025 17:50
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www.findaphd.com/phds/project...
@nebiolabs.bsky.social
@multidefence.bsky.social
Exciting PhD opportunity! Uncover the molecular mechanism of the MADS bacterial immune system and its synergy with CRISPR-Cas. Based in the Szczelkun lab in Bristol with strong collaboration with the Blower lab at NEB and opportunities to work with other amazing research groups! Link below:
This autonomous system ensures destruction of non-self DNA without harming self DNA—an elegant solution to phage infection and horizontal gene transfer threats.
New preprint!
Using single-molecule and kinetic assays combined with nanopore, myself, @alex-hg.bsky.social, @oscart32.bsky.social & co showed that the SauUSI restriction enzyme from S. aureus recognizes methylated DNA and initiates a motor-driven shredding process.
www.biorxiv.org/cgi/content/...
Happy that the final version of our Lamassu work @yli18smc.bsky.social is now out:
www.nature.com/articles/s41...
Thanks again to our awesome collaborators @mblokesch.bsky.social and David and co and Mark Szczelkun and @steven-shaw.bsky.social and the DCI Lausanne @fbm-unil.bsky.social
Alt : Structure of the apo Lamassu protein complex. Schematic model of the active LmuA tetramer nuclease (top right). Lamassu icon (top left).
Glad to share the work of @yli18smc.bsky.social and co on Lamassu, a bacterial defense system related to Rad50/Mre11 (RM). While RM carefully trims DNA ends for repair, Lamassu chops up the host chromosome. Our study reveals how it is regulated to minimize damage, activating only during infection.
I've been learning Welsh but I'm glad I'm only working with E coli
I got one of a woman in office clothes pitching Christianity to me for some reason