Associations between superficial white matter microstructure and diverse cortical properties revealed through a computational approach based on 3D histology and 7-Tesla MRI: journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/... Transient microglial activity during postnatal development regulates infant memory persistence and retrieval.
journals.plos.org/plosbiology/... Participants learned new complex tasks faster when these shared a simple task, and EEG decoding revealed associative representations of these shared tasks, linking neural association strength to behavioral generalization.
Speech comprehension relies on predictive mechanisms, but does the brain prioritize expected or unexpected information? This study shows that sharpening of sensory representations and prediction error processes co-exist at different hierarchical levels. journals.plos.org/plosbiology/...
1/ "Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans" - out now in @plosbiology.org, led by Michele Colombo, Jacopo Favaro, & Marcello Massimini. π§
A liability framework for high-risk neural devices | Science www.science.org/doi/10.1126/...
New paper in Imaging Neuroscience by Britta U. Westner, Tim M. Tierney, et al:
Cycling on the Freeway: The perilous state of open-source neuroscience software
doi.org/10.1162/imag...
we're crowd-sourcing a searchable repository of tangible benefits stemming from federally-funded research. Come enjoy the great stories; or send in an idea; or volunteer to join the team.
publicusaresearchbenefits.com
please share and re-share so we get more great stories in there!
Coupled neuronal activity, gGM, PFI, and CSF fMRI signals during burst-suppression anesthesia. Top left: Experimental design: fMRI recording under deep sevoflurane anesthesia in a Philips Achieva 3.0T scanner. Bottom left: Example scan positioning in a representative subject. Schematic depiction of the fMRI volume superimposed on a sagittal T1-weighted image with representative slice positions for the gGM and PFI masks and slice 1, which contains the CSF mask. Middle: Simultaneous recordings of the EEG with an MRI-compatible, 64-electrode cap with equidistantly arranged electrodes (Easycap) and of three fMRI masks, depicted in representative slices: gGM (white), PFI (blue), and CSF (red). Right: Simultaneously recorded signal time courses from one subject under burst-suppression anesthesia: EEG (green), gGM fMRI (black), PFI fMRI (blue), and CSF fMRI (red). Suppression and burst periods are indicated in light blue and light orange, respectively.
The directed motion of #CerebrospinalFluid #CSF in the #brain is key for the distribution & removal of solutes, but how is this flux modulated? @bzottlab.bsky.social &co show that changes in total cerebral #blood volume drive the flow of CSF in humans @plosbiology.org π§ͺ plos.io/4lOrHKm
Schematic of the two-stage operational mechanism for serial dependence. The past-trial goal-based report (upper panel), stored in distinct mnemonic formats in the sensory (purple box) and prefrontal cortex (green box) (middle panel), is reactivated during present-trial information processing (lower panel). The pastβpresent interactions occur in two stages: early repulsion and late attraction.
What is the neural basis of attractive #SerialDependence? This study shows that a previous decision is reactivated during both sensory encoding and #DecisionMaking, creating a 2-stage βrepulsive-followed-by-attractiveβ past-present interaction process @plosbiology.org π§ͺ plos.io/42JCYmq
Top: Snapshots of the representative escape responses of WT (upper) and NaVDKO (lower) zebrafish at 4 dpf in normal water. Images were captured every 2βms. Scale bar: 1βmm. Middle: Representative Ca2+ imaging of WT myocytes at 3 dpf embryos. Numbers below the images indicate time from the beginning of the recording. Fluorescent intensity is shown in color. Bottom: Ca2+ imaging of WT myocytes at 5 dpf in the presence of 1 ΞΌM TTX.
Are action potentials in vertebrate muscle essential for contraction? This study of #zebrafish lacking #SodiumChannel NaV1.4 reveals that NaVs are dispensable for #muscle contraction, so the need for muscle #ActionPotentials can vary between vertebrates @plosbiology.org π§ͺ plos.io/42EXQwx
Feedback from an avatar has different effects on decision making than feedback from another human @plosbiology.org: dx.plos.org/10.1371/jour... #neurosky #neuroscience
Deadline extended to 28th April!! Summer School in Computational Social Cognition with fantastic keynotes by Matthew Rushworth, @dianatamir.bsky.social and @davidamodio.bsky.social. Come & learn more about computational modelling, make new friends, & explore the UK's 2nd largest city ππ. Please RT!
Marmosets produced dexterous tongue movements during recordings from the cerebellar vermis. Left: Subjects made saccades to visual targets and received a small amount of food as reward via one of two tubes placed obliquely to the mouth. In the task-relevant licks, they directed their tongue to the edge of the tube to harvest food near the tip (trajectories 2, 4), or inside the tube to harvest food that was deeper (trajectories 1, 5). In task irrelevant licks, they groomed their face (trajectory 3). Top right: Subjects chose to work for consecutive trials, making saccades and allowing the food to accumulate, then harvested their cache in bouts of licking. Bottom right: The authors employed silicon probes to record from lobule VI and VII of the vermis.
The cerebellum is known to control limb movements; does it also control the tongue? @rezashadmehr.bsky.social &co reveal how the #cerebellum controls the #tongue in marmosets, highlighting the role of #PurkinjeCells in terminating tongue movement at the target @plosbiology.org π§ͺ plos.io/4lCK9Wj
π¬ Want to improve research transparency?
Join this webinar with experts from
@plosbiology.org!
Learn how this format enhances reproducibility & benefits science.
π€ Dr. @npariente.bsky.social & Dr. Nikki Osborne from
@rrr-research.bsky.social
π
April 30, 3 PM CEST #OpenScience
Ten principles for reliable, efficient, and adaptable coding in psychology and cognitive neuroscience: www.nature.com/articles/s44...
I was pleased to this as a poster at Cosyne too!
Differentially modulated olfactory learning in C. elegans. Top left: Protocol for butanone associative training in worms. Top right: After exposure to different training regimens, wormsβ olfactory navigation is measured in a controlled odor environment. Bottom: Example trajectory after three different training conditions.
How do worms navigate based on learned experience? @andrewleifer.bsky.social @jpillowtime.bsky.social &co reveal flexible behavioral strategies & distributed neural computations underlying learning-dependent odor #navigation in #Celegans @plosbiology.org π§ͺ plos.io/4bYZs7c
"after all, scientists are problem-solvers. If the solution was easy, wouldnβt we have figured it out by now?"
Check out my Editorial w/ @npariente.bsky.social discussing portable peer review, reviewer pools, AI, paying reviewers... &other solutions proposed for making peer review more sustainableπ§ͺ
Top left: Representative brain confocal stack of dFB-Split>UAS-mCD8GFP. Green, anti-GFP; magenta, anti-nc82. Top right: Representative brain confocal stack of dFB-Split>UAS-Kir2.1.EGFP. The authors observed 23.40 Β± 0.75 (n = 5) dFB23E10Υ84C10 neurons in dFB-Split>UAS-Kir2.1.EGFP brains. Green, anti-GFP; magenta, anti-nc82. Bottom left: Representative confocal stack of a female VGlut-AD (84713); 23E10-DBD>UAS-mCD8GFP brain. Yellow and red arrows show non-dFB neurons. Green, anti-GFP; magenta, anti-nc82 (neuropile marker). Bottom right: Representative confocal stack of a female VGlut-AD (82986); 23E10-DBD>UAS-mCD8GFP brain. Yellow and red arrows show non-dFB neurons. Green, anti-GFP; magenta, anti-nc82 (neuropile marker).
Sleep regulation in #Drosophila. @sdissel.bsky.social &co show that #cholinergic #neurons in the dorsal fan-shaped body (dFB) play a major role in #sleep modulation in this neurochemically heterogeneous region of the fly brain π§ͺ @plosbiology.org plos.io/42uPczp
I am pleased to report that our paper on dFB neurons is available on Plos Biology. I am extremely grateful to Dave and Brandon, my grad students, Jen, our technician/lab manager and the many undergraduate students involved in this.
journals.plos.org/plosbiology/...
Just arrived in Montreal yesterday night and look forward to attending my first #cosyne conference. Let me know if you are around and would like to chat about publishing your work in @plosbiology.org or just meet for a coffee #cosyne2025
Neuroscience faces a unique problem: It is the only field of research in which the researcherβs understanding is generated by the very thing it is trying to understand, writes @markdhumphries.bsky.social in his latest column for The Transmitter.
www.thetransmitter.org/systems-neur...
We're in BPoD again! Fantastic images from @b-wink.bsky.social (you can see another pic of hers in pole position on our homepage this week: journals.plos.org/plosbiology/)
Sam Gershman writes beautifully about how theory-free neuroscience prevents the field from reaching its promise. Beautiful and true. Most folks do not test hypotheses. Running a NHST does not a hypothesis make. www.thetransmitter.org/theoretical-...
![Third instar larval brain of the genotype [repo-Gal4 UAS-PGRP-LE STAT92E::GFP mdr65-tdTomato] stained forSTAT activity (anti-GFP staining, green), subperineurial glial cells (anti-dsRed staining, magenta), and neural lamella (anti-Laminin staining, blue). Credit: Bente Winkler](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5522ztebtekoor5efelihqhb/bafkreicv3ruxgfrmq4tksz23yehyhs7yyqzqt3oy3n6npygsjp54r7fkje)
Third instar larval brain of the genotype [repo-Gal4 UAS-PGRP-LE STAT92E::GFP mdr65-tdTomato] stained forSTAT activity (anti-GFP staining, green), subperineurial glial cells (anti-dsRed staining, magenta), and neural lamella (anti-Laminin staining, blue). Credit: Bente Winkler
The #BloodBrainBarrier (BBB) prevents immune cells & pathogens from entering the brain. @b-wink.bsky.social &co show that during #neuroinflammation in #Drosophila, immune cells can cross the BBB by degrading its ECM through a JAK/STAT-regulated pathway π§ͺ @plosbiology.org plos.io/4k1TTIG
PLOS has issued a statement on recent US Executive Orders and scientific integrity.
We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry.
plos.io/3D4O8cH
UNC-31 regulates enhanced spontaneous release in the excitatory synapses of cpx-1 mutants. The image shows representative body bending states (top) and color maps of curvature (bottom) in wild-type, cpx-1(ok1552), cpx-1(ok1552); unc-31(e928), cpx-1(Ξ12), and cpx-1(Ξ12); unc-31(e928) worms.
How is SNARE-mediated synaptic vesicle release regulated in inhibitory #synapses? This study reveals that the #exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner in #Celegans inhibitory synapses π§ͺ @plosbiology.org plos.io/4jRm255
We checked how easy it is to match up people's brain maps after spatial normalisation. Turns out very! Maybe that surprising to many in the field - but my impression has long been that people are a bit in denial about deidentifying data. #neuroskyence #visionscience
doi.org/10.1101/2024...
