Justine Couble

How does the malaria parasite regulate co-expression of genes? By recruiting them into transcription factories, courtesy of MORC et al. A fantastic team effort led by @jessmbryant.bsky.social with Jacques Serizay @singh-parul.bsky.social, @ju-couble.bsky.social @rkoszul.bsky.social

High-resolution map of the Plasmodium falciparum genome reveals MORC/ApiAP2-mediated links between distant, functionally related genes - Nature Microbiology Micro-C provides insights into genome organization in Plasmodium falciparum and defines the machinery used to spatially coordinate antigenic variation and stage-specific genes that are crucial for inf...

OUT NOW: High resolution map of the Plasmodium falciparum genome reveals MORC/ApiAP2-mediated links between distant, functionally related genes
@jessmbryant.bsky.social sky.social @singh-parul.bsky.social
@ju-couble.bsky.social ‬ #MicroSky

www.nature.com/articles/s41...

A metabolism-chromatin axis promotes ribosome heterogeneity in the human malaria parasite The transmission of the most virulent human malaria parasite, Plasmodium falciparum, relies on its survival in the contrasting environments of the human host and mosquito vector. One of the most fasci...

Thrilled to share that the main part of my PhD work is now on bioRxiv!
Curious about how Plasmodium regulates its ribosomes? Check it out!
Led by @sebbaumgarten.bsky.social with great collaboration from @tizvignolini.bsky.social

www.biorxiv.org/content/10.1...

N6-methyladenosine primes the malaria parasite for transmission Sudden environmental changes are a recurring challenge for unicellular organisms, but a necessity for many to progress through their lifecycle. To transmit from its human host to mosquito vector, mala...

Ready for the most beautifully sophisticated m6A modification program out there?

It’s sex-specific, controls a developmental transition and is temperature-sensitive. Dream team led by Selina, with @ameyasinha.bsky.social @jessmbryant.bsky.social @tizvignolini.bsky.social @ju-couble.bsky.social

Malaria parasites are an extreme example of ribosome heterogeneity. But how do they control which ribosomal RNA to express when?

Check out this mountain of work led by @ju-couble.bsky.social with @tizvignolini.bsky.social @jessmbryant.bsky.social

www.biorxiv.org/content/10.1...