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SFB Targeted Protein Degradation

@sfb-tpd-vienna

FWF-funded Austrian Research Consortium of the labs of Sascha Martens, Alwin Köhler, Andreas Bachmair, Gijs Versteeg, Tim Clausen, David Haselbach, Yasin Dagdas, Silvia Ramundo, Georg Winter, Christian Becker & Ilaria Piazza. www.protein-degradation.org

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08.03.2024
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Latest posts by SFB Targeted Protein Degradation @sfb-tpd-vienna

Only one week to register and submit your abstract❗
Sign up now to 💾 your spot ➡️ www.protein-degradation.org/symposium/

08.03.2026 22:40 👍 2 🔁 1 💬 0 📌 0

And we can't wait 🤩 to welcome you soon @kirsteinlab.bsky.social to our symposium #ubfriends2026!

23.02.2026 17:05 👍 2 🔁 0 💬 0 📌 0
A multivalent adaptor mechanism drives the nuclear import of proteasomes - Nature Communications Nuclear protein homeostasis relies on proteasome import into the nucleus. Here the authors identify how assembled human proteasomes are transported across the nuclear pore complex and reveal a mechani...

This is a video summarizing our recent paper (www.nature.com/articles/s41...)

youtu.be/eNY2CRlYTRo

12.02.2026 06:54 👍 24 🔁 10 💬 1 📌 0

And a new paper from the lab. A follow up to a previous study in which we elucidate the mechanism of the nuclear transport. Read the full story: www.nature.com/articles/s41...

11.02.2026 17:12 👍 41 🔁 21 💬 1 📌 0
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SAVE THE DATE: Ubiquitin & Friends Symposium 2026 on April 29-30 or even better, sign up now: lnkd.in/eEQmaCYT
It takes place at Van Swieten Hall, 1090 Vienna & is organized by the SFB Targeted Protein Degradation (incl. numerous research groups at Vienna BioCenter)
@sfb-tpd-vienna.bsky.social

19.02.2026 08:11 👍 15 🔁 13 💬 0 📌 0

Fantastic teamwork by Irene Schwartz & Valentina Budroni from the lab of @versteegga.bsky.social @maxperutzlabs.ac.at together with colleagues in our SFB consortium & beyond 👏Great to see the story out @natcomms.nature.com
🔗 www.nature.com/articles/s41...

22.02.2026 10:36 👍 11 🔁 7 💬 0 📌 0
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Paper alert! 📢 How do cells fight viruses without harming themselves? 🧬 In @natcomms.nature.com, the @versteegga.bsky.social lab uncover a previously unknown safeguard that keeps DNA-mutating antiviral enzymes in check, protecting the genome while preserving antiviral defense ➡️ tinyurl.com/4xbxz9e8

30.01.2026 11:05 👍 22 🔁 9 💬 2 📌 1

Why do pathological protein aggregates persist in cells and how can we overcome this?
In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy #Tau #Proteostasis

Out now 👇 www.biorxiv.org/content/10.6...

14.02.2026 13:34 👍 39 🔁 16 💬 2 📌 0

Have a look at our new structure of co translational folding in yeast. This is collaborative work initialized by the Rospert lab from the @uni-freiburg.de. Structural work has been done by the amazing @lgrundmann.bsky.social Stay tuned for the next ribosome paper from him, following very soon.

19.01.2026 11:09 👍 43 🔁 15 💬 1 📌 0

If you are interested in #ubiquitin related topics (Who isn’t???) & looking for a friendly and collegial meeting where you can talk to anyone & everyone, this is your meeting!

10.01.2026 11:54 👍 19 🔁 4 💬 0 📌 0
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Thrilled to be hosting Brenda Schulman, @aakritijain.bsky.social, @crismayorruiz.bsky.social @davidbalchin.bsky.social, @hemmo-lab.bsky.social, Ian Ganley, @kirsteinlab.bsky.social, Juliette Fedry, @elliottlab.bsky.social & @plantophagy.bsky.social - BIG THANKS for accepting the invitation 🙏

10.01.2026 00:47 👍 7 🔁 4 💬 1 📌 0
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Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna!
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026

10.01.2026 00:47 👍 34 🔁 21 💬 1 📌 3

📢 Extended Application Deadline:
🗓️27 January 2026❗
www.nature.com/naturecareer...

22.12.2025 15:34 👍 2 🔁 2 💬 0 📌 0
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📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

31.10.2025 09:24 👍 27 🔁 43 💬 0 📌 3

Indeed big news 📣! Congratulations to @martenslab.bsky.social for receiving an ERC Synergy Grant — his third ERC-funded project 👏👏👏
See all about it below👇

06.11.2025 13:09 👍 4 🔁 0 💬 0 📌 0

Absolutely honoured to see our work featured on this month’s cover! 🎉🧬

Artwork by the incredibly talented @doroteaartscience.bsky.social 👇

13.08.2025 05:04 👍 51 🔁 10 💬 3 📌 0
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Opportunity for skilled hands and sharp minds - at any career stage! 💪 The Köhler Lab is seeking a full-time lab technician to support their research on nuclear envelope biology, chromatin regulation, and cellular stress resilience - apply here ➡️ tinyurl.com/bdfy3w2h

11.09.2025 07:00 👍 6 🔁 3 💬 0 📌 0

Congrats to all scientists! 👏 The @versteegga.bsky.social lab has long collaborated with the Clausen lab, and this new study once again highlights the collaborative spirit of the @vbcscitraining.bsky.social ⤵️

28.08.2025 09:53 👍 6 🔁 2 💬 0 📌 0
Full Professorship in Molecular Mechanisms of Disease The Max Perutz Labs - one of Europe’s leading institutes for basic research in the life sciences - invite applications for a Full Professorship in Molecular Mechanisms of Disease. We are seeking outst...

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

04.09.2025 10:25 👍 82 🔁 58 💬 2 📌 3
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Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery - Nature Cell Biology Adriaenssens et al. show that unlike soluble cargo receptors, transmembrane cargo receptors initiate autophagosome biogenesis by recruiting the FIP200/ULK1 or WIPI–ATG13 complex, revealing unexpected ...

🍹@martenslab.bsky.social @elias-adriaenssens.bsky.social & co show that, unlike soluble, transmembrane cargo receptors initiate autophagosome biogenesis by recruiting the FIP200/ULK1 or WIPI–ATG13 complex, revealing unexpected flexibility in the selective #autophagy machinery.
bit.ly/4lpGh9P

14.08.2025 20:07 👍 14 🔁 9 💬 0 📌 0

Ready to launch🚀 your own lab? @maxperutzlabs.bsky.social are looking for a #tenure-track Assistant Professor👇👇 Supportive, collaborative institute embedded @viennabiocenter.bsky.social with strong infrastructure and excellent training programs.
🔗 www.maxperutzlabs.ac.at/news/open-po...

29.07.2025 08:31 👍 3 🔁 3 💬 0 📌 0

🚀Great work led by @elias-adriaenssens.bsky.social in the Martens lab @maxperutzlabs.bsky.social shows a new mechanism for #mitophagy initiation, revealing unexpected flexibility in the assembly& activation of the #autophagy machinery👇
Check it out 🔗 www.nature.com/articles/s41...

25.07.2025 15:26 👍 9 🔁 4 💬 0 📌 0

Exciting findings, out now @natcellbio.nature.com 👇👇
Congratulations Elias & all co-authors!

25.07.2025 15:22 👍 2 🔁 0 💬 0 📌 0

❗Exciting #PhD opportunity in the Piazza Lab 👇 @iplab.bsky.social @scilifelab.se

#PhDPosition 🧪🧑‍🔬

22.07.2025 08:05 👍 0 🔁 0 💬 0 📌 0

📣Exciting opportunity at @maxperutzlabs.bsky.social 👇
A great chance to join an outstanding research environment, based at campus @viennabiocenter.bsky.social Spread the word or apply!
🆕 #professorship #Professur
🔗 www.maxperutzlabs.ac.at/fileadmin/us...

08.07.2025 14:40 👍 2 🔁 2 💬 0 📌 0
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Full Professorship in Molecular Mechanisms of Disease - Vienna BioCenter, Austria job with Max Perutz Labs, University of Vienna | 12841053 Join theMax Perutz Labs as Full Professor to unravel disease mechanisms—from metabolism and stress to RNA regulation, epigenetics, and immunity.

Exciting and rare opportunity to join the @maxperutzlabs.bsky.social and the @viennabiocenter.bsky.social as a Full Professor!
www.nature.com/naturecareer...

02.07.2025 07:18 👍 36 🔁 29 💬 0 📌 2
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The @viennabiocenter.bsky.social PostDoc Program call is now open! We have 16 fully-funded positions for scientists with a PhD in biology, chemistry, physics, bioinformatics etc.

Apply here: training.vbc.ac.at/post-docs/vi...

#VBCPostDoc

02.06.2025 11:28 👍 36 🔁 22 💬 2 📌 1
VIP³ Post Doc Program (2025 - 2030) VIP3 is a postdoctoral fellowship program at the Vienna BioCenter offering three – year fellowships that are open to candidates with backgrounds in life sciences, chemistry, physics, medicine, enginee...

postdoc opening in vienna: study lipid droplets (LDs) with integrative structural biology, uncover how LD proteins shuttle between cytosol & nucleus to regulate lipid metabolism, organelle architecture and immune response. #VIP3 #lipidtime #cryoEM #coffee training.vbc.ac.at/post-docs/vi...

24.06.2025 21:03 👍 11 🔁 11 💬 0 📌 2
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👀 Did you know?

The Vienna BioCenter offers an English speaking life science community in the most livable city in the world!

Want to be part of it?

The VIP³ PostDoc Program call is open – apply now for this unique opportunity! training.vbc.ac.at/post-docs/vi...

#VBCPostDoc

23.06.2025 07:16 👍 8 🔁 6 💬 1 📌 1

👏 Big CONGRATS to @sramundo.bsky.social for receiving an FWF @fwf-at.bsky.social ASTRA Award 🌠✨
See all about it 👇

02.07.2025 14:46 👍 3 🔁 3 💬 0 📌 0