Jenny Regan

We're hiring! Enjoyed @jackholcombe.bsky.social PhD Prize talk @edrc2025.bsky.social @fly-eds.bsky.social? We're recruiting a #postdoc to explore how cell biology is patterned in the #Drosophila renal system. Come join us for live-imaging, molecular cell biology and omics! Deadline 25th January.

Interested in how life history may shape the gut microbiome of a wild mammal? Keen on getting to work with an iconic long-term study system in Scotland?

Check out this PhD opportunity with me, Josephine Pemberton and @gfalbery.bsky.social

Reach out to chat more!

www.findaphd.com/phds/project...

Deep3DSIM: Super-resolution imaging of thick tissue using 3D structured illumination with adaptive optics Deep3DSIM enables super-resolution imaging >130 µm into complex tissues of fixed and live specimens in an upright configuration, allowing sample manipulation, as well as rapid refocusing without th...

elifesciences.org/articles/102...

I am very excited to share with you our publication building Deep3DSIM microscope using adaptive optic. It allows imaging into an intact fly brain >130 microns with high quality 3DSIM as well as remote focusing without moving the objective or specimen.

Infectious bacteria, but not the microbiota, induce a NOX-ATM-cytokine pathway that controls epithelial turnover Nagy et al. identify a NOX-ATM-cytokine signaling axis in the Drosophila gut that is activated by infection independently of DNA damage. This pathway promotes enterocyte loss, cytokine production, and...

Our new study is out in Cell Reports!
We show that the DNA repair pathway ATM-γH2Av is repurposed in the gut during infection, even without DNA breaks. Pathogens, not microbiota, trigger it via NOX to clear damaged cells and drive stem cell regeneration. www.cell.com/cell-reports...

Predictors of protein evolution in the drosophilid immune system The evolutionary dynamics of immune genes are shaped by diverse selective pressures, yet the relative roles of gene-level traits, functional specialization, and pathway context remain poorly understoo...

Another preprint from @pankajd.bsky.social !
www.biorxiv.org/content/10.1...

Congratulations Domi Kwecka and @nishaphilip.bsky.social on their elegant work on the requirement for plasmodium CBP-O in crossing the mosquito midgut - it was fun to be involved! 🦟

Toward more sustainable research: reducing the environmental impact when working with Drosophila Abstract. The ever-increasing amounts of plastic waste and greenhouse gas emissions worldwide threaten our environment. Biomedical laboratories across the

Now proper out: doi.org/10.1093/gene...

Strain variation identifies a neural substrate for behavioral evolution in Drosophila Sexual selection acts on heritable differences within species, driving the parallel diversification of signal production in one sex and behavioral responses in the other. This coevolution implies that...

Exciting new Ruta lab preprint by @annaryba.bsky.social et al. on the neural underpinnings of intraspecific behavioral variation: Strain variation identifies a neural substrate for behavioral evolution Drosophila

www.biorxiv.org/content/10.1...

Redox Dyshomeostasis Links Renal and Neuronal Dysfunction in Drosophila Models of Gaucher and Parkinson's Disease Gaucher disease (GD), the most common lysosomal storage disorder, is caused by bi-allelic mutations in the GBA1 gene. Variants in GBA1 also represent the most frequent genetic risk factor for Parkinso...

New from the Kinghorn Lab! 🧠🔬 Our latest preprint shows that in fly 🪰🧬 Gaucher’s & Parkinson’s 🧠 models, kidney dysfunction drives neurodegeneration - supporting emerging links between renal health & Parkinson's. You can read it here:
www.biorxiv.org/content/10.1...

Helen Weavers

Our latest interview is with 2025 @bscb-official.bsky.social WICB early career medal winner Helen Weavers @helenweavers.bsky.social‬. We hear about what winning the award means to Helen, her research and her advice on staying resilient.
journals.biologists.com/jcs/article/...

How does nutrient-responsive #mTORC1 sense the key amino acid #glutamine?
Gianluca Figlia, Aurelio Teleman et al @telemanlab.bsky.social identify a combination of GCN2-dependent processes triggered by secondary depletion of asparagine in glutamine-starved cells
www.embopress.org/doi/full/10....

Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants - GeroScience Human longevity, which is coupled to compression of age-related disease, is a heritable trait. However, only few common genetic variants have been linked to longevity, suggesting that rare, family-spe...

I am very proud to present you the first paper from the main research line of my group at the @mpiage.bsky.social in collaboration with my current group @molepi.bsky.social @bds-lumc.bsky.social at the LUMC, which is now published in @geroscience.bsky.social!

link.springer.com/article/10.1...

Different ways to die: harnessing variation in Drosophila reveals loss of tolerance and resistance over age and sex-specific association between infection susceptibility and lifespan It is widely accepted that susceptibility to infection increases with age. The reason often invoked is the dysregulation of the immune system, which is both cause and consequence of ageing. However, w...

New preprint - varied routes to ⬆️ infection susceptibility over age - via bona fide immunosenescence, but also often via reduced tolerance 🪰🕰️🦠☠️

⬆️ risk to die from infection predicts lifespan in males. Great group effort from the lab!

www.biorxiv.org/content/10.1...

Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

🎉Excited to share our latest paper, published in Nature Communications!🎉

"Enhancing autophagy by redox regulation extends lifespan in Drosophila"

#redox #metabolism #ageing #Drosophila

@natcomms.nature.com @mrc-lms.bsky.social

doi.org/10.1038/s414...

Transcriptomic analysis of non-model Drosophilidae reveals novel AMP candidates Background Drosophila melanogaster has been a valuable model for dissecting the molecular architecture of innate immunity. However, the family Drosophilidae encompasses over 4000 species, spanning dee...

Next paper from @pankajd.bsky.social !

www.biorxiv.org/content/10.1...

A within-host infection model to explore tolerance and resistance A mathematical model of pathogen within-host dynamics and experimental validations elucidates the interplay between immune response, damage and pathogen proliferation, highlighting the limitations of ...

It is difficult to interpret single #pathogen burden during #infection. It is hard to untangle default in resistance and tolerance to explain #susceptibility. We help making sense of with-host dynamics and give tools to study infection, especially in #Drosophila.
elifesciences.org/articles/104...

Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8 The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon...

In our last preprint we identify endogenous dsRNAs capable of activating the interferon response. Could these be relevant to our understanding of DiGeorge syndrome (22qDS)?

In collaboration with @herassr.bsky.social and @heick.bsky.social labs

www.biorxiv.org/content/10.1...

Estrogen-related receptor is required in adult Drosophila females for germline stem cell maintenance Adult tissue function is dependent on intrinsic factors that mediate stem cell self-renewal and proliferation in response to changes in physiology and…

The final version of my lab’s recent paper on the role of estrogen related receptor in regulation of germline stem cells is now available in @devbiol.bsky.social. You can read the full text here:
www.sciencedirect.com/science/arti...

Tam Dalyell Prize Lecture - Edinburgh Science Join this year's Tam Dalyell Prize for Excellence in Engaging the Public with Science winners to hear about their work with rural schools.

Petra and Aidan are giving a public lecture on April 6th (THIS SUNDAY) at the Science Festival all about their public engagement program for which they won the Tam Dalyell prize for Excellence in Engaging the Public with Science :) www.edinburghscience.co.uk/event/tam-da...

“Bluesky has won”.

Please retweet… 😉

We're based in the Ashworth Laboratories, King's Buildings, University of Edinburgh. Photo shows the main staircase in the entrance to the Ashworth, stone steps from the 1920s, decorated with a series of bright, colurful banners depicting the science that's tackled in the building.

I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.

Estrogen-Related Receptor is Required in Adult Drosophila Females for Germline Stem Cell Maintenance Stem cell self-renewal and proper tissue function rely on conserved metabolic regulators to balance energy production with inter-organ metabolic trafficking. The estrogen-related receptor (ERR) subfam...

My lab has a new preprint that is available! 🧵below.
www.biorxiv.org/content/10.1...

A divergent cyclic nucleotide binding protein promotes Plasmodium ookinete infection of the mosquito Colonisation of the mosquito by the malarial parasite is critically reliant on the invasive ookinete stage. Ookinete invasion of mosquito is coordinated by the apical complex, a specialised parasite s...

📣📣 🦟 Wondering what the putative EPAC in Plasmodium does. See our new study characterising a cryptic cyclic nucleotide binding protein required for mosquito infection by the ookinete. Well done Domi Kwecka and team #ookinete #malaria
www.biorxiv.org/content/10.1...

📢Job alert

Are you interested in Drosophila genetics, insects, innate immunity, evolution? We are offering an exciting Group Leader position within the NetRNA consortium (labex-netrna.cnrs.fr/presentation...)

See below for more information and do not hesitate to contact us.

The Royal Society's Newton International Fellowships will open for applications next week on 21 January. These fellowships are for non-UK early career scientists who wish to conduct research in the UK. Find out more on our website: #RSGrants royalsociety.org/grants/newto...

EastBio: Identifying tissue signals that control cellular longevity at University of Edinburgh on FindAPhD.com PhD Project - EastBio: Identifying tissue signals that control cellular longevity at University of Edinburgh, listed on FindAPhD.com

If you're looking for a PhD studentship, we have an exciting opportunity to study why some cells live longer than others. Results could help design better cell-based therapies. #EASTBIO #macrophages
www.findaphd.com/phds/project...

A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster - Nature Communications Organisms regulate their feeding behavior to prevent overconsumption of certain nutrients. Here, the authors identify the importance of gut hormones in suppressing protein overfeeding.

Excited to see our new gut hormone paper in @naturecomms.bsky.social in collaboration with our alumnus Dr. Yuto Yoshinari (Gunma Univ.) and others!
A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster.
www.nature.com/articles/s41...

Looking forward to a fabulous European fly meeting in Alicante! #EDRC2025 #Drosophila 👇🏻👇🏻👇🏻

EastBio: Investigating the interplay between obesity and immune dysfunction using Drosophila at University of Edinburgh on FindAPhD.com PhD Project - EastBio: Investigating the interplay between obesity and immune dysfunction using Drosophila at University of Edinburgh, listed on FindAPhD.com

@nehaagrawal.bsky.social and I have an exciting EastBio PhD opportunity investigating the interplay between obesity and immune dysfunction, in beautiful Edinburgh. Deadline 17th January. Please share!

www.findaphd.com/phds/project...

Postgraduate scholarship We offer up to 30 scholarships to displaced people to study on a full-time postgraduate programme at the University of Edinburgh, starting in September 2025. Applications will open on 2 December 2024 ...

Applications are open for the Education Beyond Borders Postgraduate Scholarships at #edinburghuni for 2025/2026.

Closing date is 3 February 2025.

Find out more at the information session on 10 January. All details below:

global.ed.ac.uk/education-be...