Perhaps the most puzzling part:
We see a paradox: the rsRNA length shift is progressive⏳yet the global RNA profile shows an "Aging Cliff"📉.
Cliff or Progression? Maybe the gradual shift is the forerunner—accumulating silently until it triggers the cliff.
bsky.app/profile/qich...
Our special issue "Genomic Mosaicism in Human Development and Diseases" on Genes www.mdpi.com/2073-4425/16... is officially out! Thank you all authors for your contributions! Thanks, Xincen, for writing the editorial with me.
Welcome, Mitchell!
• The cis and trans activity maps revealed cell type-specific active enhancers bound by differentially expressed TFs.
Highlights
• H3K4me1 ChIP-STARR-seq enabled the quantification of cell type-specific enhancer activities with high-resolution.
• Cross-transfection of the ChIP-STARR-seq libraries into two cell lines revealed the enhancers cis and trans activity maps.
High-resolution dissection of human cell type-specific enhancers in cis and trans activities (sciencedirect.com/science/arti...) a long journey form @wang__meng
and Dr. Wu, glad to be part of this!
