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Raquel Fueyo

@fueyoraquel

Group Leader at Max Planck Institute of Molecular Genetics https://www.molgen.mpg.de/fueyo-lab Gene regulation | Transposons | Human embryo development

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13.11.2024
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Latest posts by Raquel Fueyo @fueyoraquel

Flyer for symposium: https://ctrlepiedit.sciencesconf.org/

Flyer for symposium: https://ctrlepiedit.sciencesconf.org/

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

09.03.2026 13:15 πŸ‘ 76 πŸ” 53 πŸ’¬ 3 πŸ“Œ 5
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The role of KRAB zinc-finger proteins in expanding the domestication potential of transposable elements - Nature Genetics This Perspective explores the co-evolution of transposable elements and KRAB zinc-finger proteins in relation to their integration into human gene regulatory networks, highlighting their potential eff...

Find our latest Perspective article in Nature Genetics on "The role of KRAB zinc-finger proteins in expanding the domestication potential of transposable elements" at www.nature.com/articles/s41..., with implications for the future of research on the cause of human disease.

02.03.2026 13:40 πŸ‘ 39 πŸ” 19 πŸ’¬ 0 πŸ“Œ 1

Bravo! Congratulations!

26.02.2026 05:01 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Redirecting

Our most recent work on the β€œfunction and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the threadπŸ‘‡ for the highlights of our findings.

25.02.2026 16:01 πŸ‘ 122 πŸ” 60 πŸ’¬ 9 πŸ“Œ 5
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We are hiring! Join the Jachowicz lab as a postdoctoral researcher. The project focuses on understanding the dynamics of ncRNAs using high-resolution and single-molecule microscopy approaches. Link below πŸ‘‡

25.02.2026 08:35 πŸ‘ 9 πŸ” 6 πŸ’¬ 1 πŸ“Œ 2
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Ancient co-option of LTR retrotransposons as yeast centromeres - Nature Evolutionarily related β€˜proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

Our paper is now out in Nature:

β€œAncient co-option of LTR retrotransposons as yeast centromeres”

www.nature.com/articles/s41...

A short thread on how retrotransposons helped give rise to yeast point centromeres.

1/14

18.02.2026 16:03 πŸ‘ 227 πŸ” 115 πŸ’¬ 8 πŸ“Œ 10

Looking forward to it!

17.02.2026 17:23 πŸ‘ 12 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

Ever notice that when one gene is disrupted, its orthologs get upregulated? This phenomenon, known as transcriptional adaptation, has been controversial and mysterious - glad to see that we are starting to learn how it works.

13.02.2026 21:42 πŸ‘ 51 πŸ” 16 πŸ’¬ 2 πŸ“Œ 1
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Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system Transposable elements (TEs) make up about half of the human and mouse genomes and play important regulatory roles in immune responses. However, the cis -regulatory contribution of TEs to immune cell d...

New Year, New Paper!🎊

Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
www.biorxiv.org/content/10.6...

Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧡

07.01.2026 19:45 πŸ‘ 54 πŸ” 18 πŸ’¬ 1 πŸ“Œ 2

🚨New paper from our team on our favorite sex locus ANTSR! 🚨New collaboration with @hugodarras.bsky.social , led by our talented @chuanxinyu.bsky.social, we show that ants, bees and stinging wasps share an ancient sex locus, a suspicion we had when we first found the locus in the Argentine ants!

06.01.2026 05:18 πŸ‘ 23 πŸ” 5 πŸ’¬ 2 πŸ“Œ 1
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Programmed β€˜DNA splicing’ removes transposons from genes Nature Reviews Molecular Cell Biology - A study that showed that programmed DNA elimination in somatic genomes of ciliates involves excision of intrusive, transposon-derived sequences from genes.

Happy to begin the year with the publication of a Journal Club article - Programmed β€˜DNA splicing’ removes transposons from genes.
rdcu.be/eXBym

05.01.2026 14:07 πŸ‘ 36 πŸ” 10 πŸ’¬ 0 πŸ“Œ 0

Don't miss this great opportunity!

03.01.2026 16:25 πŸ‘ 4 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

🧠Si eres Investigador/a Postdoctoral y quieres incorporarte a nuestro lab #Parkinson #Metabolism #Mitochondria

- 5 aΓ±os desde la lectura de tesis.
- 1 aΓ±o de estancia internacional.

⚠️Contrato postdoctoral de 3 años con estabilización.

ContΓ‘ctame: pgonzalez4@us.es

πŸ“IBiS, Sevilla

03.01.2026 14:05 πŸ‘ 3 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
Senior Bioinformatician - Biodiversity Cell Atlas Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...

Open Senior Bioinformatician position at
@sangerinstitute.bsky.social
Tree of Life, to work on the Biodiversity Cell Atlas initiative with @marakat.bsky.social and me.

πŸ“… Apply by January 18
πŸ”— sanger.wd103.myworkdayjobs.com/en-US/Wellco...

Please share with anyone who might be interested!

02.01.2026 13:12 πŸ‘ 20 πŸ” 30 πŸ’¬ 0 πŸ“Œ 1

I’m so excited to share that I’ve accepted an assistant professor position at the University of Colorado Anschutz, BMG department and Barbara Davis Diabetes center! I’m so grateful to many who have helped me get here, especially mentors at Joslin, @hmsbpa.bsky.social @leadingedgeprogram.bsky.social

19.12.2025 23:08 πŸ‘ 35 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0
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La Junta convoca ayudas por valor de 9,01M€ para contratar a 65 investigadores doctores - Esta lΓ­nea de incentivos incluye el compromiso de las universidades de crear una plaza con el mismo perfil de la ayuda concedida

🚨 Postdoc opportunity!
If you’re interested in applying for a postdoctoral contract in #Neuroscience, #BrainEnergyMetabolism & #ParkinsonsDisease, email me: pgonzalez4@us.es

πŸ”— lajunta.es/6697y

24.12.2025 00:18 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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🧬 Are you interested in synthetic biology, CRISPR-Cas9 genome editing and cutting-edge genomics? Apply by 07.01.2026 to join Stefan Mundlos’ lab @stemundi.bsky.social at the MPIMG. #IMPRS-BAC #gradschool! @nataliabenetti.bsky.social
πŸ‘‰ www.molgen.mpg.de/5124667/Mund...

11.12.2025 14:07 πŸ‘ 11 πŸ” 7 πŸ’¬ 0 πŸ“Œ 1

Very happy that this part of my postdoc work is now out as a preprint!! Our findings reveal a new mechanism by which retroviral pandemics may have shaped primate brain evolution πŸ§¬πŸ’πŸ§  This was a true team effort! w/ @ofeliakarlsson.bsky.social @raquelgarza.bsky.social @jakobssonlab.bsky.social #TEsky

14.12.2025 22:10 πŸ‘ 14 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0

Excited to co-organize with @weieli.bsky.social a symposium at SMBE 2026 on how synthetic & systems biology can illuminate the molecular mechanisms of evolution. Honored to have @christianlandry.bsky.social as invited speaker! Join us!

05.12.2025 23:16 πŸ‘ 14 πŸ” 7 πŸ’¬ 1 πŸ“Œ 0
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We are excited to share our new preprint:

SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.

www.biorxiv.org/content/10.64898/2025.12.01.691499v1

03.12.2025 18:53 πŸ‘ 46 πŸ” 21 πŸ’¬ 2 πŸ“Œ 1

Tomorrow (Thursday) at the Systems Virology Journal Club, Noor Youssef will present her work with Debbie Marks on developing an AI model that predicts how viruses evolve to evade the immune response.

Paper: pubmed.ncbi.nlm.nih.gov/40345199/

04.12.2025 02:18 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.

We have been mapping mRNA modifications for over a decade.

=> Characterizing their functions -- especially on translation -- is a research frontier.

30.11.2025 14:36 πŸ‘ 50 πŸ” 22 πŸ’¬ 0 πŸ“Œ 0

The IMPRS-BAC is an outstanding PhD program in Europe. And the endogenous retroviruses in development... what can I say? So much exciting biology to uncover! 🦠🧬#TEsky #StemCells
Read the instructions and apply! ⬇️⬇️⬇️

28.11.2025 10:00 πŸ‘ 18 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

Thank you Matt! :)

28.11.2025 09:49 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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πŸ”¬ Hot #PhD topic: Single-molecule fluorescence and super-resolution microscopy! Use quantitative nanoscale imaging to map nuclear organization. Apply by Jan 7 to join Johannes Stein’s Lab @jmstein.bsky.social & #IMPRS-BAC #gradschool!

πŸ‘‰ www.molgen.mpg.de/5098010/stei...

25.11.2025 14:18 πŸ‘ 19 πŸ” 14 πŸ’¬ 0 πŸ“Œ 0

πŸͺ± Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.

24.11.2025 13:03 πŸ‘ 61 πŸ” 38 πŸ’¬ 1 πŸ“Œ 1

We are excited to participate this year again in the VBC summer school! If you want to work with me and my amazing student Maria, apply!

21.11.2025 15:36 πŸ‘ 4 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Registration is open for "The complex life of #RNA" 2026 @embl.org in Heidelberg!

Excellent invited speakers and 30 short talks and even more flash talks selected from the abstracts!

20.11.2025 12:53 πŸ‘ 31 πŸ” 18 πŸ’¬ 0 πŸ“Œ 0
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It's always special when you find your own paper in the table of contents of the journal 😍

"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form

www.cell.com/developmenta...

18.11.2025 16:11 πŸ‘ 84 πŸ” 20 πŸ’¬ 3 πŸ“Œ 1
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IMPRS-BAC #gradschool: Our new groupleader @sedonamurphy.bsky.social has an open PhD project in her lab. Topic: Spatial feedback between epigenetic regulation and chromatin regulation. Apply by Jan 7, 2026!
πŸ‘‰ www.molgen.mpg.de/5091778/Murp...

18.11.2025 16:05 πŸ‘ 19 πŸ” 11 πŸ’¬ 0 πŸ“Œ 0