Another week, another #TylerTuesday! This Tuesday, Tyler is knocking out mesothelin in his tumor models. Good luck, Tyler!

Congrats to PhD CANDIDATE John Zhu for passing his oral qualifying exams today! Proud of you, John!

Guess What Day It Is #TylerTuesday

Happy #TylerTuesday everyone! Hope you're all having a great week🫀

SSRIs Elevate Intratumoral Serotonin and Enhance Antitumor Immunity Major Finding: Serotonin transporter depletes intratumoral serotonin which dampens CD8+ T-cell antitumor immunity.Concept: Serotonin transporter inhibition with SSRIs drives T-cell antitumor immunity ...

ICYMI: SSRIs Elevate Intratumoral Serotonin and Enhance Antitumor Immunity, a #ResearchWatch summary of a new study by Dr. Bo Li, @liliyanglab.bsky.social, and colleagues at @dgsomucla.bsky.social @uclastemcell.bsky.social

aacrjournals.org/cdnews/news/...

It's #TylerTuesday!!

Congratulations to Sean Shen for passing his oral qualifying exams and becoming a PhD Candidate! We're proud of you, Sean!

It's #TylerTuesday!
Last week PhD Candidate Tyler Halladay shared his research on Engineering iPSC-derived gdT cells for solid tumor therapy with his UCLA Pharmacology community. Thanks for being a great representative of our lab, Tyler!

doi.org/10.1016/j.ce...

Nobody knows what that means, James

Congrats to Dr. Bo Li and James Elsten-Brown on earning second place in UCLA TDG's #LABEST2025 poster competition for their work on SERT regulation of serotonin-dependent antitumor immunity, based on their research in doi.org/10.1016/j.ce...
Way to go, boys!

Thank you to the Broad Stem Cell Research Center for providing us the ability to do this research!

UCLA researchers unite to develop immunotherapy they hope will transform ovarian cancer treatment For decades, the story of ovarian cancer treatment has often followed the same pattern: surgery, chemotherapy, recurrence, repeat.This was the grim reality Dr. Sanaz Memarzadeh encountered as a second...

This #WorldOvarianCancerDay, we highlight the work of Dr. Sanaz Memarzadeh and Dr. Lili Yang, who have teamed up to develop a novel immunotherapy they hope will transform ovarian cancer treatment. ➡️ bit.ly/3XsEVBS

Common antidepressants could help the immune system fight cancer, UCLA study finds A widely used antidepressant drug could help the immune system fight cancer, according to a new UCLA research study.Selective serotonin reuptake inhibitors, or SSRIs, significantly enhanced the abilit...

A UCLA study suggests that common antidepressants could enhance the immune system’s ability to fight #cancer and suppress tumor growth. Repurposing these existing FDA-approved drugs could speed up the process of bringing new cancer treatments to patients. stemcell.ucla.edu/news/common-...

UCLA researchers led by Dr. Lili Yang have discovered a promising new method to treat myeloid malignancies, a group of blood cancers, using off-the-shelf CAR-NKT cells. Learn more this #WorldCancerDay how this study could improve patient outcomes: bit.ly/4hLW0yf

Lili Yang, UCLA leverages the power of hematopoietic stem cells to generate CAR-NKT for immunotherapy

Harnessing Stem Cells for Off-The-Shelf CAR-NKT Cell Therapy

Absolutely, James! Serotonin is such an ancient molecule, we may just be scratching the surface. We're excited to see work continue to push SSRIs repurposed for cancer therapy to the clinic!

We're excited for the opportunity to share our research with everyone! Thank you @cp-cell.bsky.social for showcasing our lab's hard work.

Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis Serotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell antitumor immunity and synergize with anti-PD-1, highlighting SSRIs as potential cancer immunotherapeutics.

Now online! Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis

I’m a very lucky person 👍

Common antidepressants could help the immune system fight cancer, UCLA study finds A widely used antidepressant drug could help the immune system fight cancer, according to a new UCLA research study.Selective serotonin reuptake inhibitors, or SSRIs, significantly enhanced the abilit...

And, as always, all under the guidance of Dr. Lili Yang, our amazing PI and mentor-- featured in the news article published by UCLA Newsroom and @uclastemcell.bsky.social. Thanks to all our team members, collaborators, and donors for making our work possible! stemcell.ucla.edu/news/common-...

‼️ @uclaupdates.bsky.social Reports: Who's the team behind identifying serotonin transporter as a tumor immunotherapy target? Dr. Bo Li leads a team of post-docs, grad students and undergrads in identifying immune checkpoints. And of course our lab manager Jie Huang! newsroom.ucla.edu/stories/anti...

We're very proud of the work Dr. Bo Li et al. have accomplished

Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis Serotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell ...

Can serotonin and SSRIs help T cells kill cancer?
Our @cp-cell.bsky.social article by Dr. Bo Li, doctoral candidate James Elsten-Brown and their team reports "Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis!" www.cell.com/cell/fulltex...

Bo really did a great job with this one.

Thanks James! We are proud of Dr. Li and the great work he and his team continually put out!