Romain W. Sala

Offline cerebello-cortico-striatal dynamics predict motor strategy exploration and retention in skill learning https://www.biorxiv.org/content/10.64898/2025.12.09.693142v1

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Together, these findings show that cerebellar communication with the forebrain continues beyond active behavior, shaping how motor skills are stabilized and adapted.

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While brain-wide strategy-specific replays of activity predicted trial-to-trial changes in motor strategy, cerebellar sleep spindle-like activity was associated with an efficient consolidation of these changes across sessions.

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These assemblies reactivate in two distinct offline states: during cerebellar sleep spindle-like events associated with consolidation, and inter-trial activations that predict shifts in motor strategy on upcoming trials.

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Combining neurophysiology and optogenetics in the rotarod task, we demonstrate that motor-skill learning engages distributed neural assemblies encompassing the cerebellum, motor cortex, and striatum.

Offline cerebello-cortico-striatal dynamics predict motor strategy exploration and retention in skill learning Learning a motor skill requires exploring multiple possible solutions to find and retain an optimal strategy. The exploration and consolidation of the motor strategy are usually considered to be segre...

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I am excited to share that our new preprint with the team Neurophysiology of Brain circuits at IBENS @ibensens.bsky.social is now out on bioRxiv!
www.biorxiv.org/content/10.6...