Bobby Hollingsworth

Senior Scientist, Protein Sciences in South San Francisco, California, United States of America | Research & Development at Genentech Apply for Senior Scientist, Protein Sciences job with Genentech in South San Francisco, California, United States of America. Research & Development at Genentech

Our department at Genentech is hiring. We're looking for a freshly-minted PhD (0-3 years) protein biochemist / structural biologist to join as a Sr Scientist. A rare opportunity to join our group leader job family at a more junior level than we usually hire.

Big news from Boltz today: we’re launching Boltz Lab, a new platform with new small-molecule + protein design agents, announcing Boltz PBC and a $28M seed round, and sharing a multi-year partnership with Pfizer. More below!

Today, my NIH colleagues and I did something scary but really important. We spoke up about egregious harms we are seeing happen to research participants and public health through thoughtless and politicized policies at NIH. 🧵1/3

apnews.com/article/nih-...

This is awesome! I've been hoping to see some sort of FKBP/SBP-hook/localization sequence approach to better understand whether the biophysical properties of membrane clustering promote inflammasome assembly. Useful insights towards finding the minimally sufficient activation sequence!

Do you consider depositing government-funded research into NCBI for free as information control? Barring all deposition of research into free non-governmental outlets would be a step far but I don't see value in allowing private companies to extract rent and control prestige currency.

This might be the only issue where I find common ground with RFK Jr: the for-profit journal system warps the incentives driving science, with serious consequences. Still, it does not come close to offset the harm he's done to U.S. biomedical research.

US healthcare science has been devastated under RFK. However, it's unclear why we need to be paying such absurd publishing fees; moving towards at-cost publishing, without political connections into journals, would actually be much better for the scientific enterprise!

The NYT wants you to think universities became dependent on government. This is false.

The government invested in the national research infrastructure by competitive grants to universities. The taxpayers built this. It got us to the moon. Won the Cold War. Created Silicon Valley. Made the McRib.

From Nobel prize winning cancer researcher Bill Kaelin
Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...

Way to go Cornell!!

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...

"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL

We called out Harvard in the past for inaction. So now we are happy to speak out with praise.

This is a major step forward.

It’s not just a lack of capitulation. It’s an aggressive effort leaning into public comms — exactly what is needed. Bravo to Harvard 👏

Excited to see this reporter characterized in more depth after its initial use awhile back--works well and I deposited a few StayGold versions of it on Addgene in the meantime (#228044, #228043)

A headshot of Felix Kraus on a light blue background with dark blue text reading “Felix Kraus, Team Harper.” The "Open Science Champion" badge and ASAP logo are also present.

🎉 This month, we are recognizing Felix Kraus from CRN Team Harper as our #OpenScience Champion for ensuring all research outputs associated with his recent publication were shared in public repositories. Thank you for all your hard work, Felix!

Check out his recent #publication: shorturl.at/YebyC

From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA

DOGE ends America’s golden age of biomedical research Biomedical research impacts all of us. I became curious about how drugs work after my mom was diagnosed with rheumatoid arthritis when I was a small boy. She received “gold shots” as treatment, which ...

I’m a biomedical researcher who lost his wife to cancer. Finding cures is personal to me. What’s happening at the NIH is devastating. Here’s my editorial in my hometown newspaper.

www.vindy.com/opinion/edit...

Research universities/admin/faculty need to choose whether to stand with Columbia through actions like walkouts or risk ceding free academic speech forever and becoming future targets for federal retribution at a whim.

Censor, purge, defund: how Trump following the authoritarian playbook on science and universities I have mapped 35 of the Trump administration's attacks on science and universities to the authoritarian playbook - and consider what it means for attacks still to come

My latest post is now out.

I show how Trump's attacks on science and universities are neither random nor new - they fit very precisely into the authoritarian playbook.

This means we can guess what might come next and prepare - and we must!

christinapagel.substack.com/p/censor-pur...

Totally valid and perhaps there's always been danger associated with any large gathering (such as terrorism) when neo-nazis feel comfortable marching on the street there's a larger risk to inaction, and the risks to safety will only get worse.

Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence

BREAKING: We're sending an open letter to universities across the country, offering support and urging them to reject pressure to punish international students and faculty for exercising their First Amendment rights.

Schools must hold firm against the Trump administration's censorship attempts.

Agree, but in times like these, fearmongering and not attending protests only accelerates the transition to authoritarianism before it is actually too late.

AACR urges Congress to reaffirm its long history of steadfast and bipartisan support for medical research by ensuring that NIH has all of the resources needed to advance its lifesaving mission to prevent, diagnose, and treat cancer and other diseases: AACR.org/NIH

EndoMAPV1, a Structural Protein Complex Landscape of Human Endosomes Early/sorting endosomes are dynamic organelles that play key roles in proteome control by triaging plasma membrane proteins for either recycling or degradation in the lysosome1,2,3. These events are c...

Tremendous effort and great native organellar interactome resource from Miguel and co in @harperlabhms.bsky.social : a crosslinking-MS, co-fractionation, and alphaFold interactome on isolated EEA1+ endosomes (+discovery/validation!) | www.biorxiv.org/content/10.1...

Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants Nature Immunology - Gain-of-function variants in the gene encoding NLRP3 lead to constitutive inflammasome activation and excessive IL-1β production. In this resource, authors perform...

A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis.
rdcu.be/d9iRG

Please join my cell biology colleagues and CALL Congress. emails are not as impactful. Here is a simple sample script

March 7. Stand Up For Science. Rallies in DC and nationwide. 🧪

Please visit the website and spread the word.

www.standupforscience2025.org

Deadline extended! Join us!

“New tools for managing scientific information” Organized by Iain Cheeseman, PhD (Professor, Whitehead Institute) & Jessica Polka, PhD (Open Science Program Director, Astera Institute) Tuesday, January 28, 2-4 pm, Whitehead Auditorium New developments in AI, knowledge graphs, and open science enable researchers to organize, visualize, and synthesize information in new ways. In this session, we’ll hear from creators of innovative tools for openly sharing scientific information about how they can improve your scientific workflows. This is a great opportunity to get hands-on exposure to new tools to benefit your research, as well as to learn about additional career opportunities and directions in the computational tool development space. Speakers Saif Haobsh (Astera): Fylo - AI-powered knowledge graphs Ronen Tamari (Astera): Cosmik - Transforming social media into a collective sensemaking layer for science Roy Kishony (Technion): Autonomous LLM-driven research from data to human-verifiable research papers Nadja Oertelt (Center for Open Science): Open Science Framework - a free, open platform to support your research and enable collaboration SJ Klein (Public AI, Underlay, and Wikipedia)

Curious about new tools to manage scientific information? Join us at the Whitehead on Tuesday 1/28 2-4pm...💡 @ronent.bsky.social @iaincheeseman.bsky.social @nadjaohnadja.bsky.social #openscience