Elena Grossi

Legnini Group - Human Technopole Laboratory for Molecular and Systems Biology of RNA   The Legnini Group at Human Technopole combines molecular and systems biology approaches to study gene regulation. We use synthetic biology and opt...

1/6 We're hiring! Fully funded postdoc position in my group
humantechnopole.it/en/research-...

An expanded registry of candidate cis-regulatory elements - Nature The existing ENCODE registry of candidate human and mouse cis-regulatory elements is expanded with the addition of new ENCODE data, integrating new functional data as well as new cell and tissue types...

Our paper on the newest version of the Registry of candidate cis-Regulatory Elements (cCREs) is out 🧬

Huge thanks to the many collaborators, experimentalists, analysts and software developers who made this work possible — truly a team effort!

A "meme-torial" of the science is coming soon 👀

SET1/MLL complexes control transcription independently of H3K4me3 Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!

www.biorxiv.org/content/10.6...

🚀Long overdue news!
I am thrilled to share that I've been awarded a Marie Curie Fellowship🇪🇺 to start my independent project, SIRENseek, investigating the epigenetic principles governing repressive chromatin🧬🛑
Grateful to @scaffidilab.bsky.social for hosting me at #IEO in Milan - can't wait to start!

A novel deep learning-based framework reveals a continuum of chromatin sensitivities across transcription factors The genome-wide binding of many transcription factors (TFs) depends not only on the presence of their recognition motifs, but also on the surrounding chromatin context. This raises the question of how...

Excited to share our latest preprint. www.biorxiv.org/content/10.1.... Lead by Lukas, we investigated multiple ways of assessing a TF's sensitivity to chromatin based on genome-wide binding profiles. The developed methods allowed us to quantify chromatin sensitivity across tested TFs.

Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers Neural crest induction begins early during neural plate formation, requiring precise transcriptional control to activate lineage-specific enhancers. Here, we demonstrate that SALL4, a transcription fa...

New paper from my group is out. We demonstrate that cranial neural crest (CNCC) induction requires the transcription factor SALL4 to physically recruit the BAF chromatin remodeller at CNCC-induction enhancers as early as at the neuroectodermal stage:
www.biorxiv.org/content/10.1...

Discovery Postdoctoral Fellow in Cancer Functional Genomics About the roleWe are thrilled to open applications for our Discovery Fellowship track of the Novartis Postdoctoral Fellowship Program.Come join Novartis Biomedical Research as a Discovery Postdoctoral...

We're hiring a postdoc!

Come join my lab @Novartis Oncology in Basel 🇨🇭, and employ genome engineering and functional genomics approaches to study how oncogenic Transcription Factors function at the molecular level (and how to drug them)

3+1 years! Apply!
Please RP

www.novartis.com/careers/care...

🧬 Did you catch our latest paper?

A new study from @elenagr.bsky.social and the Bernstein lab in collaboration with EpiCypher dives deep into chromatin remodeling in #melanoma, revealing how the SWI/SNF PBAF chromatin remodeling complex mediates chromatin silencing.

This work is a true testament to perseverance and teamwork, as I started it during my MSCA PhD in @maitehuartelab.bsky.social about 10y ago(!!) and was brought to the finish line thanks to @mmontesr.bsky.social's fantastic effort!💪

A lncRNA-mediated metabolic rewiring of cell senescence Grossi et al. describe how sin-lncRNA interacts with the TCA enzyme DLST to maintain mitochondrial function and metabolic balance during senescence. Depletion of sin-lncRNA causes DLST translocation t...

🎉 Beyond happy to see this story finally out @cp-cellreports.bsky.social, where we characterize a lncRNA induced in senescence to promote metabolic homeostasis 🧬🔥
www.cell.com/cell-reports...

Nice to see this story out 😉 congrats!!

Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇

Excited for this summer’s NYC Chromatin Club!

Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!

#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social

We will put forward a 500 million package for 2025-2027 to make Europe a magnet for researchers.

As well as ambitious proposals for R&I in the next EU budget.

We will also offer the best and brightest the right incentives to come to Europe ↓

The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin By mapping SWI/SNF complex subfamilies in the melanocytic lineage, Grossi and Nguyen et al. find that PBAF-only sites harbor PRC1/2 modifications and the repressive transcription factor REST. PBAF is necessary for REST to bind its target genes encoding neuronal factors. ARID2-mutant melanomas upregulate REST-controlled transcripts, which correlate with brain metastasis.

Online Now: The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin Online now:

The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin By mapping SWI/SNF complex subfamilies in the melanocytic lineage, Grossi and Nguyen et al. find that PBAF-only sites harbor PRC1/2 modifications and the repressive transcription factor REST. PBAF is ...

🎉 Excited to share my postdoc work in the Bernstein lab now online @cp-molcell.bsky.social!
🔎We explored the unique functions of the SWI/SNF PBAF complex and its relationship with TFs, and unveiled a PBAF/REST-controlled neuronal-like signature with potential implications in #melanoma brain mets🧬

I miss when the biggest controversy about mRNA was whether it correlated with protein or not.

Trump Administration Stalls Scientific Research Despite Court Ruling Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.

Trump Administration Stalls Scientific Research Despite Court Ruling www.nytimes.com/2025/02/21/s...

A nucleosome switch primes hepatitis B virus infection A reconstituted cccDNA platform facilitated the discovery of an early chromatinization event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene. The use of a small-molecule c...

I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social

From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵

www.cell.com/cell/fulltex...

6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC) The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

Single-cell mapping of regulatory DNA:Protein interactions Gene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibil...

🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics