Hadley Sikes

NIH cancels its first and largest study centered on women The Women’s Health Initiative has produced numerous influential findings

This is very sad and wasteful. A lot of the value comes from longitudinal data. Stopping early wastes all of the startup costs. NIH cancels its first and largest study centered on women | Science | AAAS www.science.org/content/arti...

Wonderful essay by @francesarnold.bsky.social! A few points of wisdom resonating with me: finding that exploration/exploitation balance, navigating chemistry/engineering tension in differing motivations and values, importance of taking time to enjoy life with kids, importance of high expectations.

That's another (much worse) way to handle things! On our call, our representative did hear some opposing views. A lot of the policies hurt Kentucky. I hope citizens there are heard.

Timelines of lawsuits are much slower than the changes that are being announced. And the highest court has already ruled that the law doesn't apply to the president.

The response from within the government she's describing does not seem up to the task, though. We're depending on the courts and our legal system.

My representative in Congress is holding a conference call now- my cellphone rang and I was given the option to stay on the line to join. She's taking questions from constituents live. It's remarkable direct outreach and people are giving voice to problems the chaos in government has created.

Graphic from United for Medical Research showing that NIH funding produces $2.46 in economic activity for every $1.00 awarded

Graphic from United for Research showing that NIH funding produced over $92B in economic activity in FY 2023

Graphic from United for Research showing that $914M in NIH grants to Florida institutions supported 14,688 jobs and produced $2.78B in economic activity

Cuts to the NIH are a strategy to strangle research universities not “reduce waste”

Another engaging #AMR IRG January workshop is in the books. The group voted on what talks they wanted to hear, and we had a fun dinner at Umami10, celebrating another year working on diagnostics, therapies, and deeper understanding to allow both. #Singapore - #MIT Alliance, #CREATE Campus

We have an opening for a postdoctoral researcher with protein engineering skills in #AMR IRG at the CREATE campus in #Singapore, as part of the Singapore-MIT Alliance for Research and Technology. Here's the link to apply: portal.smart.mit.edu/careers/care... Fun group, interesting project!

Yes! Safe travels

Banishing jetlag with a lunchtime walk in Clementi Woods Park #Singapore Weather is cool after all the rain!

Good morning #Singapore! Excited for a week of working on diagnostics and new ventures in #AMR Singapore-MIT Alliance for Research and Technology and for our year end company party #Thrixen

PPI Prediction Challenge #2 For this protein-protein interaction prediction challenge, we present three target proteins: KRAS, RAF (the KRAS binding domain), and Mdm2. For each target protein, we are providing you a list of 8 po...

Back by popular demand, I present PPI Prediction Challenge #2.

My claim: I AM SKEPTICAL COMPUTATIONAL APPROACHES CAN PREDICT WHETHER TWO PROTEINS INTERACT.

Someone prove me wrong (take two).
docs.google.com/forms/d/e/1F...

1/n

5H7c: A rabbit monoclonal antibody detecting ferroptotic cells Ferroptosis, a cell death pathway triggered by iron-catalyzed peroxidation of phospholipids, has been implicated in both disease progression and cancer treatment.1 A major challenge in studying ferroptosis has been the difficulty in detecting ferroptotic cells under physiological conditions, owing to the lack of a specific marker for ferroptosis.1 This obstacle was recently overcome by our study published in Molecular Cell, which identified hyperoxidized PRDX3 as a specific marker for ferroptosis.

"polyclonal antibody ... that recognizes hyperoxidized PRDX3 ... Owing to the limited supply, this antibody has been unavailable since publication of that study" Peroxiredoxins, super important and rudimentary tools for analysis! www.cell.com/molecular-ce...

I bet C was great!

Especially when the FDA has authorized bacterial vs not bacterial tests for the point of care!

Exciting things to come from this new lab! Prof. Kim does elegant work analyzing reaction mechanisms and transport phenomena and students will greatly benefit from learning from him! His latest paper: onlinelibrary.wiley.com/doi/full/10.... Congrats to DGIST on an excellent hiring decision.

I'd like to be added. Thanks for the initiative to connect the community!

Atlas of the plasma proteome in health and disease in 53,026 adults A large-scale proteomics study involving 53,026 individuals maps 2,920 plasma proteins to 406 prevalent diseases, 660 incident diseases, and 986 health-related traits, identifying promising biomarkers...

I always wonder if the common biomarkers in diagnostic tests are the best (including most abundant/technically easiest) or if some are common because there was some existing data and test developers all jumped on board. Glad this dataset exists! www.cell.com/cell/fulltex...

In awe of the many lab members I've coauthored with who make it look easy when it isn't, and as a journal editor am always careful not to reject solid results on the basis of language (can be revised). Much respect to those researchers who have this extra skill.

I'd like to be added!

Hope you and your child are ok! It was nuts tonight- some police came through next to me and I hoped they were going to enforce, but no...so agree that enforcement is sorely needed. It's not safe.