We think cortex might function like a JEPA. It looks like prediction errors in layer 2/3 are not computed against input (as is the idea in predictive processing), but against a representation in latent space (i.e. like in a JEPA arxiv.org/abs/2301.08243 or RPL doi.org/10.1101/2025...).
Our work with @georgkeller.bsky.social on testing predictive processing (PP) models in cortex is out on biorvix now! www.biorxiv.org/content/10.6... A short thread on our findings and thoughts on where we should move on from PP below.
Why are some males caring toward infants while others are neglectful or abusive? I'm so pleased to share work that my colleagues and I @princeton.edu have just published @nature.com (an explanatory thread to follow!) (1/8)
And save >80% on the cost by pooling 6 or more plasmids into a single sample using our free SAVEMONEY algorithm!
elifesciences.org/articles/88794
colab.research.google.com/github/Masaa...
Ooops forgot to tag my job advert for interns to join my lab with the relevant hashtags:
#NeuroJobs #NeuroSkyence
You know what? For €25, this is not a bad way to add a digital read-out to a stereotaxic frame.
I'm measuring about a 20 micron discrepancy per millimeter between the DRO and the stereotax; not terrible.
#neuroSkyence 🧠
My lab is looking for an intern interested in the molecular basis of cognitive decline. Work includes deep phenotyping of animal behavior and downstream analysis, including DLC tracking, motif mining (e.g. with Keypoint-MoSeq), and -omics. On-site at EMBL Rome, paid, 1-year commitment. DMs open.
Baseline activity of V1 interneurons connects pupil-linked arousal to engaged behavioral state https://www.biorxiv.org/content/10.64898/2026.02.05.704022v1
Here is the updated link (sorry for the misdirect):
www.nature.com/articles/s41...
We could all use some extra stress #resilience rn. But how does it work in the brain? On the surface, resilience looks like ignoring stress. Does the brain fail to respond? Or are active adaptations required? Or are resilience and susceptibility divergent paths? doi.org/10.1016/j.celrep.2025.116867
Psychophysics is a human-facing science with interventions arguably more robust than medicine.
iGluSnFR4 is now available @natmethods.nature.com
www.nature.com/articles/s41...
Glutamate indicators with increased sensitivity and tailored deactivation rates 🧪
This afternoon at #nvp2025, an entire session on cognitive #pupillometry 👁️ with talks by @anavili.bsky.social , @cstrauch.bsky.social and others. See you at 👉 12:00! #psychology
Planning a one-afternoon visual psychophysics practical for undergraduate students. Does anyone know a good platform to collect quantitative data on visual acuity, the blindspot, colour mixture, depth perception, edge detection, lateral inhibition, motion adaptation, visual illusions etc?
Thrilled this is out, led by former PD Cameron Ogg (now with her own lab at @rhodescollege.bsky.social!). It was a driven by a desire to see, in real-time, how LC activity/NE release influences downstream targets in behaving animals. SO hard to do, but Cameron did it! www.cell.com/cell-reports...
Absence of Local Retinotopy in the Mouse Optic Tract https://www.biorxiv.org/content/10.1101/2025.11.23.690078v1
Research in primate brains has been essential for the development of brain-computer interfaces and artificial neural networks. New funding and policy changes put future such advances at risk, write Cory Miller, @movshon.bsky.social and Doris Tsao.
#neuroskyence
bit.ly/47MXYLH
Still think brain regions don’t exist? That everything is everywhere? That cell types don’t matter and that everything is a dynamical phase portrait?
Wrong.
Interconnected brain modules exist at the level of fine grained transcriptomics. www.nature.com/articles/s41...
Also need a new chapter on the cancer resistance mechanisms of the whale. 📖 🐋 www.nature.com/articles/s41...
Pre-stimulus pupil-linked arousal enhances initial stimulus availability and accelerates decay in iconic memory. https://www.biorxiv.org/content/10.1101/2025.10.31.685757v1
Characteristic facial features in mice simultaneously encode not only currently used decision variables but also independent and unexpressed ones, and these features partially originate from neural activity in the secondary motor cortex
@fannycazettes.bsky.social
www.nature.com/articles/s41...
Neuropixels Ultra!
By @steinmetzneuro.bsky.social, who led a big collaboration
www.sciencedirect.com/science/arti...
Learning induces persistent chromatin loops underlying robust gene expression during memory recall https://www.biorxiv.org/content/10.1101/2025.09.30.678146v1
In the early years of my PhD I remember being asked if we'd ever treat or cure diseases like HIV or Huntington's. I remember saying maybe, but not knowing if I believed. Seeing research pay off as real impact on human lives is - incredible.
www.bbc.com/news/article...
www.bbc.com/news/article...
You could have rather put the quotation marks in "arousal", given the last sentence of the paper.
Nice and impressive, but it's basically saying that there is a low-dimensional descriptor. Now, it could have been reversed having latent brain dynamics as a predictor, and pupillometry as the target
Super proud of this collaboration with rockstar Ryan Raut - born out of playing in the sandbox in our last year of grad school! Multi-scale brain activity can be predicted from a simple measure of arousal like pupil diameter. Out with linear causality, in with dynamic systems to explain neurobiology
This one looks intriguing. Arousal "embedding" whole-brain dynamics. 🤯
#neuroskyence #compneurosky
doi.org/10.1038/s415...
It’s been a 24 hour traveling day from Portland to Pécs, which includes 2 planes, a bus, a metro, a train & a car.
I am so excited to be at ERM2025 and to be selected as a speaker in the New Perspectives, Tools and Resources session!
Our EMBL Press office has a nice little article on our recent paper on how the pupil's dynamics shape visual responses in the mouse and human.
A new look at the pupil: more than just a gatekeeper www.embl.org/news/science...
*New preprint from the lab* – “Granularity of thalamic head direction cells”
doi.org/10.1101/2025...
🧠📈 🧪
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