gotazu.bsky.social

#eNeuro: Using two mouse models of autism, Sturm et al. highlights how neural activity fluctuations in the olfactory bulb influence behavior in ASD, offering insights into sensory processing mechanisms and potential therapeutic strategies.
https://doi.org/10.1523/ENEURO.0271-25.2025

Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior - Nature Communications Neural circuitry mechanism which invigorates an animal to go from basal breathing which serves the purpose of gas exchange, to engage in the voluntary act of sniffing is not fully understood. These re...

Dopamine signaling into the ventral striatum triggers sniffing bouts.
www.nature.com/articles/s41...

Juvenile male Shank3B het mice have faster learning than WT mice in olfactory task.
www.biorxiv.org/content/10.1...

Reduced number of Thy-1 neurons in three mouse models of ASD in piriform cortex. There was also a lack of exploration of novel odors.
www.biorxiv.org/content/10.1...

Columnar organization in the olfactory bulb revealed using stimulation in slices.
www.biorxiv.org/content/bior...

Altered olfactory responses in Fmr1 KO mice - Scientific Reports Scientific Reports - Altered olfactory responses in Fmr1 KO mice

Olfactory deficits in mouse model of Fragile X. Less exploration of social odors, increase exploration of novel non-social odors. Increased olfactory bulb volume.
www.nature.com/articles/s41...

Autism spectrum disorder variation as a computational trade-off via dynamic range of neuronal population responses - Nature Neuroscience Individuals with autism spectrum disorder show neural patterns different from those of neurotypical individuals. Here the authors show that this variation reflects a computational trade-off between ac...

Shallow neural response curves proposed as the basis for higher small difference discrimination and more neural response variability in ASD.
www.nature.com/articles/s41...

ErbB inhibition rescues nigral dopamine neuron hyperactivity and repetitive behaviors in a mouse model of fragile X syndrome - Molecular Psychiatry Molecular Psychiatry - ErbB inhibition rescues nigral dopamine neuron hyperactivity and repetitive behaviors in a mouse model of fragile X syndrome

Hyperactivity of dopaminergic neurons in substantia nigra in mouse model of fragile X underlies repetitive behaviors.
www.nature.com/articles/s41...