Excessive #inflammation?
We uncover @cp-immunity.bsky.social that #IFN-I via #ISG15 in macrophages lowers #mitochondrial membrane potential, boosts #efferocytosis, and self limits #ISG amplification: a built in brake that promotes resolution. Open-access: www.cell.com/immunity/ful...
#immunosky
14.02.2026 11:40
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Thanks, Super-Gillian! Considering all the accumulated rainfall in Spain this winter, I bet this hay fever season will be quite intense in our country. I encourage people with allergies to consider getting vaccinated, the onlyway to modify the course of the disease, not just relieve the symptoms.
27.02.2026 10:19
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This work was only possible thanks to the collaboration of @jimenez-saiz-lab.bsky.social
27.02.2026 05:36
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Thanks Antonio!
27.02.2026 05:34
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6/6 In summary: fine-tuning cross-linking stoichiometry is key to designing allergen vaccines that are less reactive yet still immunogenic — a meaningful step toward safer therapies.
26.02.2026 18:22
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5/6 Using different glutaraldehyde-to-protein ratios to polymerize Phleum pratense and Betula verrucosa extracts, we observed that the larger and more densely cross-linked the polymers were, the lower their IgE reactivity and their ability to activate mast cells.
26.02.2026 18:22
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3/6 Today, glutaraldehyde-polymerized allergen extracts are routinely used to treat allergic patients. However, it remains unclear how the proportion of reactants affects their structure and safety. Are all polymers the same?
26.02.2026 18:22
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2/6 The conceptual model stemmed from the detoxification of bacterial toxins with formaldehyde and the generation of toxoids nearly 100 years ago—where immunogenicity is preserved while toxicity is reduced. pasteur.fr/en/research-...
26.02.2026 18:22
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🧵 1/6 Vaccinating allergic patients carries risks: the patient’s IgE recognizes allergen extracts and can trigger severe adverse reactions. To address this, Dr. Roy Patterson (1970s) proposed an innovative approach: modifying the extracts by polymerizing them with glutaraldehyde.
26.02.2026 18:22
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Preprint: Type I IFN activates border-associated macrophages to drive MHC-I–dependent immune surveillance after stroke
www.researchsquare.com/article/rs-8...
20.01.2026 23:47
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@salva-iborra.bsky.social and Co in @jem.org elegantly sow that plasmacytoid DCs expand tissue-resident memory CD8+ T cell responses during viral reinfection
rupress.org/jem/article/...
13.01.2026 08:08
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My main PhD paper is finally out! 🎉
After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺.
@natimmunol.nature.com
It all started with an unexpected observation 🔍:
👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice.
1/11 🧵
02.01.2026 16:57
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On the use of murine models: Results should be interpreted with caution. Batf3-deficient mice have been traditionally used as a model to study the function of cDC1; however, this transcription factor seems to play other essential roles in other immune populations👇
30.12.2025 22:23
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Qian Zhang et al. @casanovalab.bsky.social @rockefeller.edu report a fatal case of avian #influenza #H5N1 infection caused by autoantibodies neutralizing type I IFNs. These rogue autoantibodies are common, especially in elderly people. rupress.org/jem/article/...
(1/2) 🧵 👇
05.12.2025 18:15
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Feel better during the day than at night during #influenza? Find out the “Role of IL-10 signaling in the #circadian control of host response to influenza infection” www.mucosalimmunology.org/article/S193...
05.12.2025 13:47
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mRNA vaccines 💉don't cause death but prevent it
Massive study from France showed that mRNA vaccines reduced deaths and saved lives @mahmoudzureik.bsky.social @jama.com
jamanetwork.com/journals/jam...
05.12.2025 16:41
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Fascinating study revealing how NK cells can eliminate intracellular E. coli infecting the urothelium.
-Just a comment on the NK depletion experiment, NK1.1 is also expressed by ILC1s, NKT and most γδ T1 cells (IFN-γ producers).
05.12.2025 17:29
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👇No os lo perdáis! Hoy, a las 19:00 h, Oscar Palomares hablará en Allergotrends (Inmunotek) sobre los"Avances en inmunidad innata entrenada en inmunoterapia específica de alérgeno: Vacunas bacterianas para la prevención y tratamiento del asma alérgica". eventos.quodem.com/allergotrend...
27.11.2025 08:03
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Delighted to have written this Insight article together with @victor-bosteels.bsky.social and Will Stainier about a cool new story by Tam et al. And with a title to honour Jason Cyster’s heritage.
13.11.2025 21:18
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In @jem.org, Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/...
#MucosalImmunology
25.11.2025 19:30
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pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection @jem.org
rupress.org/jem/article-...
25.11.2025 21:45
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6/6 This work was expertly led by Elena Hernández (@ucm.es/Inmunotek) and Miguel Galán (CNIC). It was only possible thanks to a remarkable collaborative effort, especially from @sancholab.bsky.social, Marc Dalod, Elena Tomasello and Santos Mañes.
25.11.2025 22:03
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5/6 In summary, our study highlights a crucial collaboration between Trm and pDCs, revealing new opportunities to enhance local immunity. Graphical abstract created with
@BioRender Iborra Martín, S. (2025) biorender.com/2nazgxd
25.11.2025 22:03
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4/6 Blocking IFN-I or depleting pDCs impaired Trm-mediated protection, both in skin reinfection with vaccinia virus and respiratory reinfection with influenza A. These cells don’t act alone: they rely on pDCs to achieve optimal immunity.
25.11.2025 22:03
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