Ángeles Hueso-Gil

Great to see this one out. I agree it was challenging but watching it unfold was definitely exciting. The team worked brilliantly, truly thankful!

Dynamics of genetic circuits in Pseudomonas protegens Genetic circuit engineering enables new cellular functions, yet most circuits are developed in the model host Escherichia coli, limiting their availab…

Latest paper out! This piece was a challenge: logic, predictability, decidability, non-model organisms, design... Kudos to @juanricomol.bsky.social & Pablo Japón #syntheticbiology #synbio #biocomputation (I'll post more on this next week) www.sciencedirect.com/science/arti...

New tech adventure: co-founded Newton Biotwins together with @mirobueno.bsky.social. We're building #DigitalTwins for the lab — starting with a flow cytometry twin. Turning #biology into an information science! newtonbiotwins.com/en/home_en/

Donde no llega la ficción Todo relato de un superviviente tiene algo de falsedad o de impostura, porque nadie que conociera el extremo del horror pudo volver vivo. Por ello, hay cosas que las palabras no pueden hacer, no sabe...

Antonio Muñoz Molina plantea en este artículo una interesante reflexión sobre los límites estéticos de la ficción (o realidad ficcionada), el cine e incluso el documental. elpais.com/opinion/2024...

Cuando escucho noticias trágicas en la tele, y veo con horror cómo les ponen banda sonora (normalmente emotiva, a veces Bob Dylan o similar...), disfrazan de cine lo que no tiene ni una pizca de belleza. La actualidad sobre la desgracia no debería plantearse con sentido estético. Porque no lo tiene.

Donde no llega la ficción Todo relato de un superviviente tiene algo de falsedad o de impostura, porque nadie que conociera el extremo del horror pudo volver vivo. Por ello, hay cosas que las palabras no pueden hacer, no sabe...

Esta interesante reflexión de Antonio Muñoz Molina plantea incluso los límites estéticos de la ficción (o realidad ficcionada), del cine e incluso el documental. elpais.com/opinion/2024...

New paper out!📢 Exploring the computing power of microbes that shapes the environment.

In this short review we talk about the "complexity gap", the distance between bottom-up genetic circuits and microbial information processes. Key questions to improve #biocomputation.

🔗 doi.org/10.1016/j.mi...

Side story: NAND gates where one input deals directly with growth control, and it is the actual physical body doing the computation. This is our initial approach to morphological computing in living cells. #biocomputation #alife

Our new strain KT-TTX is truly fascinating. Feedback welcome!

Preprint of our work tuning bacterial growth, something that changes context for genetic circuits and therefore, their behaviour. Very interesting observations from both experimental results and a model describing it in this piece of work with @mirobueno.bsky.social and @angelgm.bsky.social! :)

P.S. Y ahora… ¿qué hago yo con un vinilo si no tengo reproductor de vinilos?

After 16 years listening to @patrickwolf.music-social.com, today I finally met him in a concert. His amazing music put a soundtrack to all the high and low moments of my life since then ❤️ Thanks for that company, Patrick!

Our #ALIFE2025 paper is out! 🎉 We show that even when two circuits produce the same output, their evolutionary potential can differ greatly. #Evolution at the smallest scale.

“Parameter Evolvability in Gene Expression Models Drives Phenotypic Adaptation”
🔗 direct.mit.edu/isal/proceed...

If you are at the Emerging Applications of Microbes conference in Leuven, go to poster #24: Engineering growth control to modulate circuit host dependencies, by @angeles-hg.bsky.social. This is a brilliant story about growth rates vs. genetic circuit function. And, of course, noise! #synbio

The 2025 Retreat of the Biocomputation Lab (in wonderful Chinchón, Madrid) comes to an end. Three days of fantastic discussions, with new (and revisited) goals ahead. What a brilliant team!

Breaking News: Jane Goodall, one of the world’s most revered conservationists, died at 91. Her discoveries in the 1960s about how chimpanzees behaved in the wild broke new ground and represented what was called “one of the Western world’s great scientific achievements.” nyti.ms/42kpGxt

Noche Europea de investigadores 2025. El CSIC te llama esta noche. Talent show y concierto Biolocas YouTube video by Espacio Fundación Telefónica Madrid

Esta tarde, @angeles-hg.bsky.social y yo estaremos en el Espacio Fundación Telefónica (Gran Vía, Madrid) representando al @cnb-csic.bsky.social en el Talento Show de la Noche Europea de los Investigadores

Puedes venir a vernosgratis a las 17h o conectarte a www.youtube.com/live/z3eLvP0... :)

Llega la Noche de los Investigadores!! El viernes que viene estaremos, @redquena.bsky.social como monologuista veterano y yo como novata, junto a @cnb-csic.bsky.social y otros centros @csic.es hablando de ciencia! Podrá verse en directo en el canal de YT de #EspacioFTef #EuropeanResearchersNight

Also… not even a slight use of chatGPT. It doesn’t mean I think I can do it necesarely better, but if you enjoy writting (or any other creative activity) the pleasure of doing something by your own is much better to me!

a woman in a purple dress is doing a split ALT: a woman in a purple dress is doing a split

Today I submited my first science communication project. Independently of the result, I feel as if I completed something important!! #Fecyt Let’s go! 🥳🥳

"Rebajar impuestos a los ricos conduce a una mayor desigualdad tanto en el corto como en el medio plazo, sin ningún efecto en el crecimiento económico o el desempleo"

Construction of a syntrophic Pseudomonas putida consortium with reciprocal substrate processing Abstract. Synthetic microbial consortia can leverage their expanded enzymatic reach to tackle biotechnological challenges too complex for single strains, s

Very happy to see the final version published of our collaboration with Pavel Dvorak's lab! 🦠🧬

doi.org/10.1093/synb...

El grupo de Angel Goñi lidera un proyecto "Proof of Concept" @erc.europa.eu para desarrollar gemelos digitales pioneros y analizar en profundidad el comportamiento de células vivas
Más info: www.cnb.csic.es/proyecto-de-...
@angelgm.bsky.social
@csic.es
@sommalliance.bsky.social

La belleza del método lógico-deductivo. Fragmento presentación libro CIENCIA O PSEUDOCIENCIA [...] YouTube video by Angeles Hueso-Gil

Cuando presentamos el libro "Ciencia o Pseudociencia" hace ya 2 años, me dieron 10 minutos y carta blanca para hablar de lo que considerara oportuno. Preparé esta charlita divulgativa con mucha ilusión, y la comparto ahora por aquí, porque más vale tarde que nunca 🙂 youtu.be/4yChJadojhQ

Standardized Quorum Sensing Tools for Gram-Negative Bacteria Engineering synthetic consortia to perform distributed functions requires robust quorum sensing (QS) systems to facilitate communication between cells. However, the current QS toolbox lacks standardized implementations, which are particularly valuable for use in bacteria beyond the model species Escherichia coli. We developed a set of three QS systems encompassing both sender and receiver modules, constructed using backbones from the SEVA (Standard European Vector Architecture) plasmid collection. This increases versatility, allowing plasmid features like the origin of replication or antibiotic marker to be easily swapped. The systems were characterized using the synthetic biology chassis Pseudomonas putida. We first tested individual modules, then combined sender and receiver modules in the same host, and finally assessed the performance across separate cells to evaluate consortia dynamics. Alongside the QS set, we provide mathematical models and rate parameters to support the design efforts. Together, these tools advance the engineering of robust and predictable multicellular functions.

Just out! Want to use quorum sensing (QS) for cell–cell communication? Check this out — you might find it useful! Kudos to Paula Múgica 👏

Standardized Quorum Sensing Tools for Gram-Negative Bacteria | @pubs.acs.org @acs.org #SyntheticBiology @sevaplasmids.bsky.social pubs.acs.org/doi/10.1021/...

Standardized Quorum Sensing Tools for Gram-Negative Bacteria Engineering synthetic consortia to perform distributed functions requires robust quorum sensing (QS) systems to facilitate communication between cells. However, the current QS toolbox lacks standardized implementations, which are particularly valuable for use in bacteria beyond the model species Escherichia coli. We developed a set of three QS systems encompassing both sender and receiver modules, constructed using backbones from the SEVA (Standard European Vector Architecture) plasmid collection. This increases versatility, allowing plasmid features like the origin of replication or antibiotic marker to be easily swapped. The systems were characterized using the synthetic biology chassis Pseudomonas putida. We first tested individual modules, then combined sender and receiver modules in the same host, and finally assessed the performance across separate cells to evaluate consortia dynamics. Alongside the QS set, we provide mathematical models and rate parameters to support the design efforts. Together, these tools advance the engineering of robust and predictable multicellular functions.

Just published! Paula Mugica has standardized a set of #quorumsensing tools for its use in gramnegative bacteria. Their utility range from the development of #synbio #circuits inside a cell to what is even cooler: for cell to cell communication :) pubs.acs.org/doi/10.1021/...

Colamos un ESTUDIO FALSO en una revista científica | Así funcionan los PREDATORY JOURNALS

1/3 Although the issue of releasing GMOs for env bioremediation has been virtually absent of the mainstream scientific literature in Europe/US for >20 yrs, the topic has continued strong in Asia—alas in less fancy/visible journals. Time to revisit the subject in view of new global challenges 💪🏻!

We are offering a #PhD candidate position (Spanish FPI) to work with us at the @cnb-csic.bsky.social in Madrid. The project you would be part of: establish a #biofoundry at our institution, to optimize #synbio experiments from #design to #test. If interested, get in touch!

Just published!: "Genetic designs for stochastic and probabilistic biocomputing".

We explore moving beyond binary logic in #SynBio and #Biocomputation using random pulses and p-bits—embracing biological noise to design robust, invertible genetic circuits in cells.

journals.aps.org/pre/abstract...

Aprendre de la tragèdia Poques setmanes després de les riuades de l’octubre, Acció Cultural del País Valencià convocava un debat amb experts de diverses disciplines. Recorde bé les intervencions de la geògrafa Francesca Segu...

Comencem les jornades "Reflexions i accions després de la catàstrofe" @vilaweb.cat publicarà opinions començant per la meua reflexió sobre el diàleg (difícil però desitjable) entre ciència i política @iec.cat @octubreccc.bsky.social @acpv.cat @ucciuv.bsky.social www.vilaweb.cat/noticies/apr...