Muin J. Khoury

Achieving the vision of genomics to improve health for all requires a focus on diversity, equity and inclusion - Journal of Community Genetics Journal of Community Genetics -

Diversity, Equity and Inclusion are not just buzzwords: They are essential in fulfilling the vision of genomics to improve health for all! Our editorial in Journal of Community Genetics. link.springer.com/article/10.1...

Community Engagement: A Foundation for Health Equity and Resilience | AJPH | Vol. 115 Issue S2 American Journal of Public Health (AJPH) from the American Public Health Association (APHA)

Why community engagement is a foundation for health equity. Via AJPH. ajph.aphapublications.org/doi/full/10....

From Genes to Public Health: An emerging opportunity for the new Administration for Healthy America (AHA). | Muin J. Khoury From Genes to Public Health: An emerging opportunity for the new Administration for Healthy America (AHA). As the "new" Centers for Disease Control and Prevention will focus almost entirely...

From genes to public health: an important opportunity for rhe Administration for Healthy America! www.linkedin.com/posts/muin-j...

Genomics of host–microbiome interactions in humans - Nature Reviews Genetics In this Review, Ferretti et al. discuss advances in our understanding of interactions between the human genome and the microbiome, including the effects of the microbiome on host gene regulation.

The impact of host genomics on microbiome interactions in health and disease. An insightful review.
www.nature.com/articles/s41...

What is Public Health Genomics? A Day in the Invisible Life of Public… | Muin J. Khoury A day in the invisible life of public health genomics! In 2011, I wrote this blog to celebrate the field and illustrate examples of its daily impact. The examples may be outdated but the idea behind t...

A day in the invisible life of public health genomics, 2011 edition. Via LinkedIn. www.linkedin.com/posts/muin-j...

The Public Health Damage—and Personal Toll—of Federal Worker Layoffs This JAMA Forum discusses the scope of cuts made by the Trump administration to the federal workforce, the personal damage to workers, and the future of government service.

“Breaking things is easy, but fixing things is hard.” Via @jama health forum. jamanetwork.com/journals/jam...

Epilepsy at Precision Medicine Crossroads This Viewpoint describes the benefits and challenges of integrating genomic information with disease-modifying therapies for epilepsy.

This @jama.com Neurology Viewpoint describes the benefits and challenges of integrating genomic information with disease-modifying therapies for epilepsy. jamanetwork.com/journals/jam...

The Microbiome and Cancer: A Review This review in the Translational Science series summarizes current evidence regarding the human microbiome and cancer, including how the microbiota in the gut and other anatomical locations affect can...

This @jama.com review summarizes current evidence regarding the human microbiome and cancer, including how the microbiota in the gut and other anatomical locations affect cancer outcomes and response to cancer therapy. jamanetwork.com/journals/jam...

From genes to public health: the applications of genetic technology in disease prevention. Genetics Working Group. | AJPH | Vol. 86 Issue 12 OBJECTIVES: With advances in the Human Genome Project, the implications of genetic technology in disease prevention should be assessed. METHODS: The paradigm suggested in The Future of Public Health--...

From Genes to Public Health: The Beginning of the Journey, 1996. Via @amjpublichealth.bsky.social ajph.aphapublications.org/doi/10.2105/...

How public health has been upended in Trump’s first 100 days More than 20,000 jobs were eliminated, billions of dollars in scientific research has been threatened or paused, and a budget draft proposes a major restructuring of Health and Human Services.

How public health has been upended in 100 days. Via @washingtonpost.com www.washingtonpost.com/health/2025/...

Making the case for using kindness as a tool for public health action! www.nature.com/articles/s43...

Artificial intelligence in digital pathology — time for a reality check - Nature Reviews Clinical Oncology The authors of this Perspective evaluate the developments in the use of artificial intelligence (AI) in digital pathology for oncology applications between 2019 and 2024, addressing technological inno...

Can AI enhance digital pathology? Time for a reality check! www.nature.com/articles/s41...

Public Health Genomics in the US, 2025 | Muin J. Khoury Public Health Genomics in the United States 1998-2025. in 2011, Turna Ray wrote a thoughtful story in GenomeWeb entitled “Tight Budgets Defund Key CDC Effort, but Director Will Retain Focus on Public...

Public health genomics in the United States: 1998-2025. www.linkedin.com/posts/muin-j...

Thank you for speaking with me @turnaray.bsky.social and your thoughtful and balanced piece!

Axe Falls on Federal Health Workforce This Medical News article discusses the US Department of Health and Human Services plan to restructure its agencies and lay off 10 000 workers as part of the Trump administration’s Make America Health...

“If we’re not willing to invest in public health, all we have left is to be reactive, when a disaster occurs. “ jamanetwork.com/journals/jam...

Public Health Genomics 2025: The End of the Beginning! www.linkedin.com/posts/muin-j...

How the CDC’s widespread layoffs cut lifesaving health programs | Muin J. Khoury The crucial role of public health practice beyond infectious diseases: The Washington Post post piece by Lena Sun showcases how ”CDC’s portfolio has broadened over time to include a wider range of h...

The crucial role of public health practice beyond infectious diseases. www.linkedin.com/posts/muin-j...

The CDC Has Been Gutted | Muin J. Khoury | 19 comments A sad day at CDC: Today, multiple public health programs were shuttered and thousands of CDC employees were let go. This WIRED story and many others have and will continue to describe the devastating ...

The CDC has been gutted. www.linkedin.com/posts/muin-j...

“This is a moment of profound danger to public health.” @apha.org public letter. www.apha.org/news-and-med...

A feasibility study on implementing pre-emptive pharmacogenomics testing in outpatient clinics in Singapore (IMPT study) - The Pharmacogenomics Journal The Pharmacogenomics Journal - A feasibility study on implementing pre-emptive pharmacogenomics testing in outpatient clinics in Singapore (IMPT study)

Are we ready for preemptive pharmacogenomic testing? A feasibility in outpatient clinics. www.nature.com/articles/s41...

Widespread layoffs, purge of leadership underway at U.S. health agencies The move comes after Secretary Robert F. Kennedy Jr.’s announcement of a sweeping reduction of the Department of Health and Human Services.

This is heartbreaking. www.washingtonpost.com/health/2025/...

An informative review on estimating penetrance of pathogenic variants in family and population studies. www.ahajournals.org/doi/10.1161/...

Scientific journey from PSCK9 discovery in familial hypercholesterolaemia Nature Reviews Cardiology, Published online: 28 March 2025; doi:10.1038/s41569-025-01147-wCountries globally face major challenges in the early diagnosis and treatment of hypercholesterolaemia and cardiovascular disease, with numerous health inequities by geography and income. Perseverance, hard work, integrity and commitment can transform aspiration into reality. My PCSK9 story, from the discovery of its implication in familial hypercholesterolemia to the development of life-saving drugs, is a real example.

New online! Scientific journey from PSCK9 discovery in familial hypercholesterolaemia #CardioSky

Using implementation science to navigate the complexity of integrating genomics into healthcare - Nature Medicine Australian Genomics led a country-level, longitudinal project to deliver and evaluate the impact of genomics in routine healthcare.

How Australia is using implementation science to integrate genomics into healthcare. www.nature.com/articles/s41...

Disappearing Data at the U.S. Federal Government | NEJM Starting in January 2025, various government health datasets were removed, restored, manipulated, or not posted as planned. The consequences of these changes could be far-reaching.

Government data are important tools for advancing public health and innovation. The federal government is one of the most important sources of data used for “big data” applications. www.nejm.org/doi/full/10....

Transmission dynamics of the 2022 mpox epidemic in New York City - Nature Medicine Analysis of genomic and epidemiology data from 2022 in New York City show similarities between the dynamics of MPXV and HIV transmission, and highlight the role of heavy-tailed sexual contact networks...

Precision public health in action: Epidemiological and genomic analysis of the 2022 mpox epidemic in New York City highlights the similarities with HIV transmission and the role of sexual contacts networks in transmission. www.nature.com/articles/s41...

A Review of Autosomal Dominant Polycystic Kidney Disease This review discusses the pathophysiology, clinical presentation, diagnosis, treatment, and prognosis of autosomal dominant polycystic kidney disease diagnosed in adulthood.

Autosomal dominant polycystic kidney disease is the most common genetic kidney disease worldwide. An informative JAMA review. jamanetwork.com/journals/jam...

Low responsiveness of machine learning models to critical or deteriorating health conditions - Communications Medicine Pias et al. evaluate machine learning models designed to predict in-hospital mortality and 5-year cancer survivability. Multiple classification models are unable to recognize critical health condition...

Machine learning models are currently insufficient to predict critical or deteriorating health conditions in the intensive care. www.nature.com/articles/s43...

How Can Genome Sequencing Be Used for Patient Diagnosis? Genome sequencing can help diagnose patients with rare diseases and unexplained diseases, but many patients can’t access this genetic test. Lack of knowledge and awareness among both clinicians and patients is one of the barriers to access. Watch this video to learn about what genome sequencing is, its potential benefits and limitations, how often it leads to diagnosis, and what patient groups...

How can genome sequencing be used for patient diagnosis? @jama.com educational video. edhub.ama-assn.org/jn-learning/...

Precision public health in action: How artificial intelligence can help quantify the contribution of social determinants of cardiovascular health at the local level. www.nature.com/articles/s41...