This is great work. Really looking forward to how this evolves.
07.01.2026 18:53
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This is great work. Really looking forward to how this evolves.
How does a silent genome know where to begin life?
A recent study by @evahoermanseder.bsky.social shows the early embryo is not a “blank slate.” H3K4me3 marks are pre-established in gametes and guide zygotic genome activation, acting as true epigenetic memory.
#Epigenetics #DevelopmentalBiology
I finally got around to putting together a quick overview of what my book is all about.
youtu.be/xPt1xy4_i-o?...
#epigenetics #epigeneticsbook #epigenome
1/ 🎄 We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.
There's a super line up next March for the Keystone meeting in Geneva for anyone interested in chromatin and epigenetics! Not a bad spot for a Spring trip!
🧬👇🇨🇭
#KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
Deadlines are approaching for @keystoneSymposia.bsky.social #Autophagy : Mechanisms to Therapy, this February in Keystone! See scholarship, abstract and discount reg dates: keysym.us/KSAutophagy26 #KSAutophagy26
The Motamedi lab shows that Clr4 is recruited de novo to the ncRNA locus SPNCRNA230 even without Ago1 and pre-existing H3K9me. Sir2 and Clr3 (H3K9 HDACs) also accumulate there, and iterative cycles of H3K9 deacetylation then methylation spread a basal H3K9me state, which RNAi subsequently amplifies.
📆📣Join us for journal club tomorrow as Dr. Claudia Puri presents her work on "Transferrin receptor controls both autophagosome formation and closure via phosphatidylinositol 3-phosphate synthesis", a recent work published in Developmental Cell!
Email wiajournalclub@gmail.com for Zoom link
Congratulations!
Our first release in the attempt to build the Transcription Factor Binding (TFB)-OMICS during #DevBio is now out in Development @dev-journal.bsky.social
doi.org/10.1242/dev....
👉We hope many will use our data, and some will want to help mapping their beloved gene regulators in their favorite tissue
In the most recent episode we talked with @korblab.bsky.social from @upenn.edu about her work on BRD4 and the histone variant H2BE, which influences synaptic genes and neuronal activity. #podcast #epigenetics #chromatin
Listen here: www.activemotif.com/podcasts-eri...
Pls spread the word! We have a postdoc position available in the Rocha Lab @mpi-muenster.bsky.social. Join our team to study mechanisms underlying robust organ development using zebrafish embryos and human organoids.
mpi-muenster.mpg.de/career
WSTF nuclear autophagy regulates chronic but not acute inflammation is published in Nature😀 nature.com/articles/s41...
Congratulations to all collaborating groups! Fantastic effort by first author Yu Wang! Kudos to Zixhun Dou for leading the entire project!😀
WSTF nuclear autophagy regulates chronic but not acute inflammation @nature.com @terjejohansen.bsky.social
www.nature.com/articles/s41...
Fig. 1.Overview of TOR kinase signaling impacting chromatin. TOR phosphorylates a range of targets, including components of the translation machinery, downstream kinases, chromatin modifiers, transcription factors or metabolic proteins, thereby modulating their activity, localization, and nucleocytoplasmic shuttling. TOR signaling can also influence cytoskeletal dynamics, which in turn affects nuclear shape and structure. Colored elements indicate processes known to occur in plants, while those in gray refer to mammalian systems. Gray dashed arrows indicate uncertain or indirect pathways, while question marks indicate uncertain cellular localization of the process, highlighting potential areas for future research.
🧬 ⚙️ REVIEW ⚙️ 🧬
TORquing chromatin: the regulatory role of TOR kinase in chromatin function - Dong et al.
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪
If you are interested by epigenetics, early human development in excellent scientific environment in middle of Paris, we are recruiting a postdoc.
app.beetween.com/WeaselWeb/p/...
Don't hesitate to apply or share the post !
So proud of this work by #rukmini mukherjee on intersection of Cell Biology and Microbiology
New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...
Reposting - please consider applying for a lab head role @wehi-research.bsky.social in Australia. It is a wonderful place to work, in a great country and with lovely colleagues. Clearly I’m biased on all of those counts. Please repost and/or apply!
Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇
Thrilled to share our work now published on @cp-immunity.bsky.social . Big thanks to our collaborators. Here we show that short-term High-Fat diet impairs ILC3 functions in producing IL-22 through microbiota-dependent and-independent mechanisms.
Delighted to share the latest preprint from the lab led by Janith Seneviratne
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance?
We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains.
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www.biorxiv.org/content/10.1...
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Perfect as always 👏🏻👏🏻👏🏻
Absolutely thrilled to read this paper on how MORG1 limits TORC1 signaling! Fascinating insights into autophagy, revealing how WDR83 facilitates basal autophagy. Science at its best!
@terjejohansen.bsky.social
#TORC1 #MORG1 #Autophagy
How does TOR kinase signaling affect chromatin state in plants? Our latest review explores the intricate link between TOR & H3K27me3, a key epigenetic mark.
Check it out!
www.researchgate.net/publication/...
