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Vitamin D ameliorates NETosis and Th17/Treg imbalance in experimental autoimmune thyroiditis Neutrophil extracellular traps (NETs) have been implicated in various autoimmune diseases; however, their role in Hashimoto's thyroiditis (HT) remains…

NETs contribute to Th17 bias and MHC-II over-expression in HT, suggesting a role in shaping the adaptive immune response. Vitamin D restrains NETosis and restores T-cell homeostasis, highlighting its potential as an adjunctive therapy for HT.

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Meal timing represents a modifiable factor influencing metabolic health and possibly early carcinogenesis. Aligning eating behavior with intrinsic #circadian rhythms may help mitigate #cancer risk and improve long-term well-being.
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• #Circadian disruption causes #immunity risks
• Clock genes are potential targets for treating #autoimmune diseases.
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Our study revealed that depression severity in adolescents correlates with circadian desynchronization. These findings reveal the potential value of PER and SCN-OFC connectivity as biomarkers for MDD in adolescents.
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Chronoregulatory and neuroprotective effects of yeast β-glucan against systemic inflammation
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Dim blue light at night worsens high-fat diet-induced kidney damage via increasing corticosterone levels and modulating the expression of circadian clock genes Obesity is a contributing factor that increases the likelihood of developing chronic kidney disease. In recent years, studies have found that light po…

• Dim blue light at night aggravated kidney damage and fibrosis in HFD.
• Exposure to dim blue light at night increased oxidative stress and inflammation in kidney of mice fed a HFD.
• dBL altered renal circadian clock genes changes by elevating plasma corticosterone levels and acting on receptors.

‘Universal vaccine’ protects mice against multiple pathogens Nature - An innovative approach supercharges the innate immune system to provide a first line of defence against respiratory infections.

Imagine if a nasal spray could make you immune not only to the viruses that cause COVID-19 and influenza, but to all respiratory diseases

go.nature.com/4rx3aMe

Melatonin inserts into neuronal membranes, targets cholesterol-rich rafts, and connects different lipid phases without disrupting their structure.
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Chronic cold exposure and extreme temperature variability independently increase MASLD risk, with amplified effects in metabolically vulnerable populations.
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https://www.sciencedirect.com/science/article/pii/S2589004226004116

Outdoor artificial #light at night is linked to a higher risk of type 2 #diabetes and disrupted glucose #metabolism. Obesity partly explains this link, accounting for 22–36% of the effect. Vulnerable groups include the elderly, men, smokers, and those with lower socioeconomic status.

Together, these findings show that adolescent binge-like eating induces glial reactivity and dopaminergic disturbances in key reward- and control-related brain regions, alongside changes in anxiety-like and risk-taking/impulsive-like behaviors.
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Presentation and Temporal Nature of Postacute Sequelae of SARS-CoV-2 Infection in a US National Cohort
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Vitamin D Supplementation for Disease Activity and Maintenance of Remission in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis Inflammatory bowel disease (IBD) has been linked to immune dysregulation and vitamin D deficiency, leading to growing interest in vitamin D supplement…

#VitaminD supplementation effectively raises blood levels in #IBD patients. It may offer benefits - such as reducing disease activity, #inflammation, and improving quality of life - particularly in those with baseline deficiency. However, evidence is inconsistent, effects vary among patients.

Mito-Mood Hypothesis. #Mitochondria act as a central hub integrating #circadian rhythms (blue), neuroinflammation (red), and synaptic plasticity/LTP (green).

Findings demonstrate that sex and photoperiod shape hepatic redox homeostasis in obesity, supporting a melatonin-NRF2-circadian regulatory axis that connects environmental timing cues with sexually dimorphic redox responses.
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Amazing data here - just 100lux of room light while staying up late seems to delay teens enough that 8000lx of morning bright light delays them further:

Current perspectives on #circadian regulation of #mitochondrial dynamics in #mood disorders and perioperative #stress
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The role of gut dysbiosis and mitochondrial dysfunction in type 2 diabetes: Insights on pathogenesis, intervention and future perspective
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This article reviews molecular mechanisms underlying circadian rhythm disruption during aging, with a focus on telomere homeostasis, SIRT1-mediated epigenetic regulation & NAD+ metabolic pathway.
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https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2026.1709841/full

#Light pollution and risk of #diabetes: a systematic review and meta-analysis of observational studies

• Light pollution was associated with a 31% increase in risk of diabetes.
• Strongest association was observed for indoor light pollution , where risk increased by 66%.

This review synthesizes the features of gut #microbiota #circadian dynamics, the intrinsic and extrinsic factors regulating microbiota oscillations, and the precise microbial intervention measures targeting temporal patterns.
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Frontiers | Exercise interventions for sleep and cognitive dysfunction in shift workers: a systematic review of randomized trials Background and objectivesShift work disrupts circadian rhythms and contributes to poor sleep, cardiometabolic risk, and cognitive impairment, which is especi...

Structured #exercise may improve #sleep quality and cognitive function in shift workers, though substantial uncertainty remains. Moderate-intensity aerobic exercise shows promise, particularly when timed post-shift for sleep benefits or pre−/during-shift for alertness enhancement.

tPBM holds promise as an effective antidepressant strategy. Improvement in sucrose consumption, increase in Complex IV activity in prefrontal cortex, and the increase in NO concentration in hippocampus, associated with a reduction in damage to membrane lipids.
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Family History and Solar Insolation in Bipolar I Disorder - PubMed This study highlighted the association between family history, solar insolation, and gender in international patients with bipolar I disorder. Given the profound effects of sunlight on human health, the family of patients with bipolar disorder who live in the same location with the same solar insola …

People with bipolar disorder who live in places with very dark winters and very bright summers are more likely to have relatives also affected by mood disorders. This suggests that extreme differences in access to sunlight may 'trigger' the genetic predisposition to this illness within families.

Hormonal, metabolic and metabolomic biomarkers in long COVID Long COVID (LC), a complex syndrome affecting approximately 6–12 % of individuals post infection, is characterized by persistent, fluctuating, or prog…

This review synthesizes current evidence on hormonal, metabolic, and metabolite biomarkers in LC. While vitamin D deficiency is prevalent in LC, being associated with neurocognitive symptoms, delayed recovery and poor physical performance.

Painter Schmidt-Rottluff (1906)
by Emile Nolde

These findings reveal that adipocyte circadian disruption impairs metabolic health through mitochondrial complex I dysfunction, establishing clock control of complex I as a key regulator of metabolic homeostasis.

We discuss how #plastics can impact cellular #metabolism, affect developmental #brain processes, and increase vulnerability to neurodevelopmental disorders and #depression.
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