Geoffroy Mallaret

Brain and Body Communication in Health and Disease In this cross-journal Collection we invite submissions of basic, pre-clinical, and clinical studies focusing on the bidirectional communication between the ...

www.nature.com/collections/...

Baby-to-baby strain transmission shapes the developing gut microbiome - Nature A metagenomic survey of babies attending the first year of nursery detected extensive baby-to-baby microbial strain transmission, pointing to social interactions in infancy as crucial drivers of infan...

www.nature.com/articles/s41...

gutSMASH 2.0: Extended Identification of Primary Metabolic Gene Clusters From the Human Gut Microbiota Microbiota-derived metabolites serve as key messengers mediating host–microbe and microbe–microbe interactions, often through specialized primary meta…

Now available online: the new 2.0 version of gutSMASH, with capabilities to detect 12 new types of catabolic gene clusters relevant to gut microbiome ecology, as well as predictions of their regulation through transcription factor binding site detection. www.sciencedirect.com/science/arti...

The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution - Nature The Biodiversity Cell Atlas aims to create comprehensive single-cell molecular atlases across the eukaryotic tree of life, which will be phylogenetically informed, rely on high-quality genomes and use...

please share this postdoc job alert! come join the budding Biodiversity Cell Atlas initiative as a postdoc or senior postdoc at @sangerinstitute.bsky.social working closely with @arnausebe.bsky.social and me to make progress on what we cover in this paper www.nature.com/articles/s41...

Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome - Nature Communications Here, by integrating faecal metabolomics, metagenomics, and habitual dietary data of two large human cohorts, the authors show that faecal metabolites reflect diet and gut microbiome interactions, pre...

Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome.

By integrating faecal metabolomics, metagenomics, and dietary data Falchi et al. show that faecal metabolites capture mediations between diet and the gut microbiome

www.nature.com/articles/s41...

Local B cell maturation and mast cell regulation of choroid plexus function in early life. Postnatal development is a critical period for the maturation of the nervous and immune systems. The choroid plexus (CP) within the brain ventricles guides brain development through the production of ...

Excited to share our new preprint: “Local B cell maturation and mast cell regulation of choroid plexus function in early life” www.biorxiv.org/content/10.1... , initiated in the lab by Laetitia Travier and led by the one and only @fakesamir.bsky.social

The gut microbiome shapes social behaviour across animal species Nature Reviews Microbiology, Published online: 14 November 2025; doi:10.1038/s41579-025-01262-yThe gut microbiome can influence brain activity and complex behaviours. In this Review, Griffiths et al. discuss microbiome-associated effects on social behaviour in laboratory model organisms, free-living animals and humans, and consider potential mechanistic pathways.

ICYMI: New online! The gut microbiome shapes social behaviour across animal species

📜It has been a pleasure to collaborate in this highly interesting study published in @commsbio.nature.com!

🎉Congrats @gmallaret.bsky.social and colleagues!

🔜And more to come from the collaboration bewteen Laetitia Davidovic's research group and Applied Metabolomics at @researchmar.bsky.social.

Thanks Marko :)

Thrilled to share our recent research with Laetitia Davidovic, investigating how p-cresol contributes to social deficits by modulating host catecholamine-biosynthesizing enzymes. A huge thank-you to the entire team for their exceptional work. Hope you enjoy it!
www.nature.com/articles/s42...

Socially parasitic ant queens chemically induce queen-matricide in host workers Taku Shimada and colleagues show that socially parasitic queens of two ant species spray their respective host queens with chemical signals that trigger host workers to kill the resident queen.

👸💀👸
www.cell.com/current-biol...

Triste d'apprendre la disparition de Philippe Taquet. L'empreinte des dinosaures restera pour moi un de mes livres de paléontologie favoris. 😢

Induction of menstruation in mice reveals the regulation of menstrual shedding During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org/content/10.1...

Unlocking the power of human milk and infant feeding: Understanding how nutrition and early microbiota interaction shapes health programming Infant feeding plays a crucial role in microbial colonization, immune maturation, and development. Human milk is a bioactive system comprising biologics that shape the infant gut microbiome and suppor...

Unlocking the power of human milk and infant feeding: Understanding how nutrition and early microbiota interaction shapes health programming 👶🍼🤱🦠🔬
www.cell.com/cell-host-mi...

Adaptive radiation and social evolution of the ants Comparative analyses of 163 ant genomes reveal extensive genome rearrangements, context-specific gene family expansion patterns, and selection on conserved pathways that together underpin the evolutio...

Adaptive radiation and social evolution of the ants 🐜🐜🐜
www.cell.com/cell/fulltex...

Gut microbiota diversity affects fish behaviour and is influenced by host genetics and early rearing conditions | Open Biology The gut microbiota influences human and animal cognition and behaviour through its effects on the endocrine and immune systems. The microbiome–behaviour relationship may be especially relevant for fish, due to their diverse evolutionary history and ...

royalsocietypublishing.org/doi/10.1098/...

The origin of vertebrate teeth and evolution of sensory exoskeletons - Nature Re-examination of the presumed Cambrian fossil fish Anatolepis reveals previous misidentification of aglaspidid sensory structures as dentine, a vertebrate sensory tissue, showing it to be a...

www.nature.com/articles/s41...

Dominance rank inference in mice via chemosensation Borak et al. reveal that male mice can infer the dominance status of unfamiliar opponents using scalable chemosensory cues. Sensory ablation experiments demonstrate that both olfactory and vomeronasal...

www.cell.com/current-biol...

Perinatal exposure to the autism-linked metabolite p-Cresol has limited impact on early development in mice but lasting effects on adult social behavior - Scientific Reports Scientific Reports - Perinatal exposure to the autism-linked metabolite p-Cresol has limited impact on early development in mice but lasting effects on adult social behavior

I am pleased to share our new study about the perinatal involvement of the microbial metabolite p-cresol in neurodevelopmental disorders. Enjoy :)
www.nature.com/articles/s41...

Sensory input, sex and function shape hypothalamic cell type development - Nature Paired transcriptomic and chromatin accessibility profiling are used to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, including cell types with ke...

www.nature.com/articles/s41...

Sensory input, sex and function shape hypothalamic cell type development - Nature Paired transcriptomic and chromatin accessibility profiling are used to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, including cell types with ke...

After last week publication from the lab on circuits of social isolation/satiety, today we publish a different line of research by @harriskaplan.bsky.social et al., on the development trajectories of hypothalamic POA cell types driving survival and social behavior.
www.nature.com/articles/s41...

A hypothalamic circuit underlying the dynamic control of social homeostasis - Nature New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social isolation and...

www.nature.com/articles/s41...

Dietary availability acutely influences puberty onset via a hypothalamic neural circuit Goto et al. measure the pulsatile activity of the reproductive center in the hypothalamic arcuate nucleus during puberty in female mice. They discover that food availability rapidly and bidirectionall...

www.cell.com/neuron/abstr...

Happy 37th birthday to the LTEE!
the-ltee.org/history/

Evidence for Endogenous Collagen in Edmontosaurus Fossil Bone Reports of proteins in fossilized bones have been a subject of controversy in the scientific literature because it is assumed that fossilization results in the destruction of all organic components. In this paper, a novel combination of analytical techniques is used to address this question for an exceptionally well-preserved Edmontosaurus sacrum excavated from the Upper Cretaceous strata of the South Dakota Hell Creek Formation. Cross-polarized light microscopy (XPol) shows birefringence consistent with collagen presence. Tandem LC-MS unambiguously identified, and for the first time quantified, hydroxyproline, a unique collagen-indicator amino acid, in acid-digested samples from the Edmontosaurus. LC-MS/MS bottom-up proteomics shows identical collagen peptide sequences previously identified and reported for another hadrosaur and a T. rex sample.

Evidence for Endogenous Collagen in Edmontosaurus Fossil Bone 🦕🦖🧪🔬
pubs.acs.org/doi/10.1021/...

The microbiota-derived bile acid taurodeoxycholic acid improves hepatic cholesterol levels in mice with cancer cachexia Alterations in bile acid profile and pathways contribute to hepatic inflammation in cancer cachexia, a syndrome worsening the prognosis of cancer patients. As the gut microbiota impinges on host me...

🎉New article from our team demonstating that a #microbiota derived #bileacid improves hepatic #cholesterol levels in mice with cancer #cachexia! Congratulations to Morgane Thibaut & Martin Roumain! Thanks to our collaborators, the FNRS and the @welbio.bsky.social www.tandfonline.com/doi/full/10....

Self-experience of a negative event alters responses to others in similar states through prefrontal cortex CRF mechanisms - Nature Neuroscience Maltese et al. show in mice that experiencing an adverse event affects future interaction with others experiencing the same stressor. These self-experience socioemotional reactions are orchestrated by...

Self-experience of a negative event alters responses to others in similar states through prefrontal cortex CRF mechanisms
www.nature.com/articles/s41...

😍

PGN is such a phenomenal intra- and inter-kingdom signalling molecule!
#MicroSky #MicrobiomeSky

Roseburia intestinalis-derived butyrate alleviates neuropathic pain Jiang et al. identified distinct gut microbiota profiles in healthy individuals and patients with shingles or postherpetic neuralgia (PHN). They developed a metagenomics-based model to assess PHN risk and showed that Roseburia intestinalis produces butyrate to alleviate pain by activating vagal nerves, suppressing pain-related brain regions in animal models.

Roseburia intestinalis-derived butyrate alleviates neuropathic pain
www.cell.com/cell-host-mi...