Excited to share this work with @vaughalle1.bsky.social! Reduction of PAI-1 activity can slow - and even reverse - vascular aging

@jamespirruccello.com @ahascience.bsky.social @malenelindholm.bsky.social

New event at #AHA2025!
GPM Symposium Model Systems: Preclinical to Phase I Bridge
Nov 7 12:30-5:15
Learn state-of-the-art systems to bridge therapies from the Preclinical to Phase I trials
Speakers: Kricket Seidman, Joe Wu, Kiran Musunuru, Vicki Parikh, Eric Adler, and more!

Trader Joe’s San Soyaki www.traderjoes.com/home/product...

Awesome talk by Dr Cindy James on the many findings from the 800+ DSP-erados network 👏🏻 DSP cardiomyopathy certainly a good example of why knowing genotype is so important
#gcchat #cardiogen #hrs2025

Agree, enormous loss

WHI Funding Announcement (April 21, 2025) Today, Women’s Health Initiative (WHI) investigators were informed that the Department of Health and Human Services (HHS) will terminate WHI Regional Center (RC) contracts at the end of their current fiscal year (September 2025). The WHI Clinical Coordinating Center (CCC) will continue operations until January 2026, after which time its funding remains uncertain. While written notification has yet to be received, investigators have been advised to expect formal confirmation soon.

This is an enormous loss: www.whi.org/md/news/whi-...

I’m not watching but did let me guess he called them transgender mice?

The NIH closes scientific evidence gaps and reduces uncertainty for health care providers. The USPSTF makes recommendations about primary care preventive services such as screenings, behavioral counseling, and preventive medications. The U.S. Preventive Services Task Force (USPSTF) evaluates evidence. USPSTF issues an I statement when appropriate (The USPSTF issues an I statement when evidence is insufficient to evaluate a preventive service’s benefits and harms). More evidence is generated. The USPSTF reevaluates the evidence. The USPSTF issues a recommendation for or against providing a service

The NIH is the largest single funder of the scientific evidence base used by the USPSTF. Eleven I statements were upgraded between 2010 and 2019. The NIH supported an average of 11 publications per I statement. This represents 29% of all publications and 62% of U.S.-based publications that provided evidence to upgrade the I statements. NIH Institutes, Centers, and Offices funded research that helped upgrade the 15 eleven I statements.

Study design: Study designs used in NIH-supported studies that informed upgraded I statements: 64% RCTs, 21% cohort studies, 5% cross-section studies, 10% other

Evidence: Characteristics of NIH-supported evidence that enabled the USPSTF to move I statements to recommended (grade A, B, or C) or not recommended (grade D) services For details, refer to: Klabunde CN, Ellis EM, Villani J, Neilson E, Schwartz K, Vogt EA, Ngo-Metzger Q. Characteristics of Scientific Evidence Informing Changed U.S. Preventive Services Task Force Insufficient Evidence Statements. Americ

Infographic from the NIH:

"Stories of Success in Disease Prevention: Informing National Recommendations About Clinical Preventive Services"

#medsky

www.nih.gov/sites/defaul...

prevention.nih.gov

More men are diagnosed with dilated cardiomyopathy than women – but is it due to higher risk or underdiagnosis?

A new study led by Dr Paz Tayal has shown it to be both - men face greater risk, but sex-specific criteria aren’t applied so women may be underdiagnosed.
imperial.ac.uk/news/260894/...

From cutting-edge devices to holistic care, hear how HFSA’s latest scientific statements are shaping #heartfailure management in this 3-chapter episode of the #HFBeat w/ Drs. Ana Barac, Michelle Weisfelner Bloom, Sarah Chuzi, @fudimmarat.bsky.social and Haider Warraich. Listen now! bit.ly/3VQxZhc

In chapter 3 (⏲️ 33:00), Drs Sarah Chuzi and Haider Warraich give Michael the rundown on integrating #palliativecare into comprehensive HF care via the HFSA consensus document. Collaboration is 🗝️!🔗 Full statement, Top 10 and Quick Highlights here bit.ly/41Lsd4m

Can’t believe it’s been a week already! Great Early Career Day session for #AHA2024 Scientific Sessions
@ahascience.bsky.social

🧬 Our dilated #cardiomyopathy GWAS out today!

📍https://www.nature.com/articles/s41588-024-01952-y

All made possible with friends and collaborators from HERMES Consortium @alberthenry.bsky.social @tomlumbers.bsky.social @jamesware.bsky.social @mrc-lms.bsky.social @imperialnhli.bsky.social #BHF

🧵 👇

Spontaneous Coronary Artery Dissection: Current Knowledge, Research Gaps, and Innovative Research Initiatives: JACC Advances Expert Panel Despite marked advancements in the recognition and diagnosis of spontaneous coronary artery dissection (SCAD) over the past decade, knowledge of the b…

🚨🚨🚨 Our new review is out highlighting research priorities for SCAD, lead by Esther Kim, Daniela Crousillat, and Amy Sarma

Spontaneous Coronary Artery Dissection: Current Knowledge, Research Gaps, and Innovative Research Initiatives: JACC Advances Expert Panel

www.sciencedirect.com/science/arti...

I know many of you have been awaiting us launching transcript expression data in gnomAD. We were waiting for the GTEx v10 release which is now out so we are finally able to launch this. Enjoy!!