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In the ACHIEVE-1 phase 3 trial, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with early type 2 diabetes. Full trial results: nej.md/4ngEZ36 #ADASciSessions
As today is World Lupus Day, we are highlighting some of our lupus contentπ¦:
Systemic lupus erythematosus genetics: insights into pathogenesis and implications for therapy bit.ly/3zkO1rK
Lupus nephritis-related chronic kidney disease bit.ly/40fvZCf
An interesting news story about CKD
'25 years ago, CKD was the 19th leading cause of death. Today it sits at 9th
"By 2050, it is projected to be the fifth leading cause of death. That is an unacceptable trajectory for a disease that is largely preventable."
amp.9news.com.au/article/5f36...
Daily monitoring of sCys in patients at risk of AKI would facilitate timely detection and potentially improve clinical outcomes. Future research should focus on validating sCys diagnostic criteria and integrating it with other biomarkers to enhance AKI management. bit.ly/CJASN0654
#ASNCJASN
Cover of the March issue of Nature Reviews Nephrology
In our March issue: Reviews on integrins, endothelin-receptor antagonists, tubuleβglomerulus crosstalk and collagens, plus Comments for #WorldKidneyDay on CKD screening, awareness, risk factors and AI-assisted detection go.nature.com/419A0GY
Fascinating read on the ever frustrating topic of publication fees: this paper estimates that between 2019 and 2023 researchers and institutions paid a whopping USD $8.968 billion for their findings to be freely accessible and that costs tripled during that time π°
arxiv.org/abs/2407.16551
Editorial by Jung-Im Shin, Antoine CrΓ©on, and Juan-Jesus Carrero:
Metformin in People With Diabetes and Advanced CKD: Should We Dare?
https://bit.ly/3P4BPzy (FREE)
SGLT2 inhibitors and kidney/bladder cancer?
"Investigating risk of cancer with SGLT-2 Inhibitors: A Case/Non-Case Study in the WHOGlobal Pharmacovigilance Database"
www.sciencedirect.com/science/arti...
π KDIGO is now on Bluesky! π
Weβre excited to connect with the nephrology community on this platform and share the latest from KDIGO, including guidelines, reports, and educational resources.
Weβd like to introduce KDIGO, what we do, and how to connect with us. π§΅π
π kdigo.org
#NephSky
Counting down the Top Ten #AJKDBlog posts of 2024:
Interviews Editor @maximalchange.bsky.social interviews Kueiyu Joshua Lin on his study recently published in AJKD:
3οΈβ£ Apixaban vs The World: Which Anticoagulant is Best for A-fib in CKD?
https://bit.ly/3wELWWb (FREE)
Kidney Biopsy Proven Diabetic and Non-Diabetic Kidney Disease and Outcomes in Dialysis Patients With Type 2 Diabetes: The REIN Registry
https://buff.ly/41M7ihk
Advancing Genetic Testing in Kidney Diseases: Report From a NKF Working Group
https://bit.ly/3ZA99V5 (FREE)
Hello, #MedSky community! Weβre excited to begin our Bluesky journey.
Here is a sampling of the trusted, influential, and essential information you can expect when you follow us:
Renal Physiology for the Clinician Series
#Nephpearls
π journals.lww.com/cjasn/pages/...
Hi everyone. Here to follow #NephSky βοΈ