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David Huang

@dcshuang

Biomedical researcher at WEHI. BCL2, mitochondria, apoptosis and targeted therapies for leukemias/lymphomas.

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05.08.2023
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Latest posts by David Huang @dcshuang

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We’re incredibly proud to share Professor Peter Gibbs has been elected a Fellow of the Australian Academy of Health and Medical Sciences πŸ‘ πŸŽ‰

He is one of 29 new AAHMSβ€―Fellows to be recognised for outstanding contributions towards medical research.

www.wehi.edu.au/news/cancer-...

28.10.2025 23:12 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1
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πŸŽ“ Applications are now open for WEHI’s International PhD Scholar Initiative.

πŸ“… Apply by Sunday 26 October 2025

πŸ”— Learn more about eligibility, scholarships and how to apply: wehi.edu.au/education/ph...

Help us spread the word by sharing with your networks!

10.09.2025 02:08 πŸ‘ 4 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
πŸ“Έ L–R: Professor David Komander, Dr Nicholas Kirk, Dr Sylvie Callegari and Dr Alisa Glukhova.β€―

πŸ“Έ L–R: Professor David Komander, Dr Nicholas Kirk, Dr Sylvie Callegari and Dr Alisa Glukhova.β€―

Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works.

πŸ”— www.wehi.edu.au/news/eureka-...

03.09.2025 21:54 πŸ‘ 30 πŸ” 11 πŸ’¬ 2 πŸ“Œ 1
Group of people posing for a photo in front of the dark, dome-shaped building of the Australian Academy of Science, known as the Shine Dome, in Canberra.

Group of people posing for a photo in front of the dark, dome-shaped building of the Australian Academy of Science, known as the Shine Dome, in Canberra.

A group of people gathered around a food truck beside a tent at an outdoor event near a drained pool. The setting includes a mix of trees and cloud-filled sky.

A group of people gathered around a food truck beside a tent at an outdoor event near a drained pool. The setting includes a mix of trees and cloud-filled sky.

A group of individuals networking at a corporate event, discussing near a table with fresh oranges while a demonstration is shown on a screen above.

A group of individuals networking at a corporate event, discussing near a table with fresh oranges while a demonstration is shown on a screen above.

In Canberra's iconic Shine Dome, we are witnessing the recognition of Australia's brightest scientific minds. Following the 2025 election of new Fellows (pictured), the total Fellowship stands at 630 Fellows.
πŸŽ₯ Don't miss the live stream of their presentations! https://bit.ly/SATS-25

02.09.2025 01:19 πŸ‘ 6 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Clare Scott inducted as Fellow of the Australian Academy of Science #ShineDome25 @wehi-research.bsky.social @science.org.au

02.09.2025 00:17 πŸ‘ 5 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
The BrainPOP research team (left to right): Professor Kate Drummond, Dr Jim Whittle, Dr Saskia Freytag, Dr Sarah Best

The BrainPOP research team (left to right): Professor Kate Drummond, Dr Jim Whittle, Dr Saskia Freytag, Dr Sarah Best

Researchers from WEHI, the Royal Melbourne Hospital & @petermaccc.bsky.social have achieved a brain cancer clinical trial world-first, providing hope to patients with low-grade gliomas.

πŸ”— www.wehi.edu.au/news/world-f...

22.08.2025 22:31 πŸ‘ 12 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0
The first detailed molecular map of human bone marrow, created by WEHI researchers using state-of-the-art spatial technology, with each colour representing a different cell type.

The first detailed molecular map of human bone marrow, created by WEHI researchers using state-of-the-art spatial technology, with each colour representing a different cell type.

Using spatial technology, WEHI researchers have mapped the bone marrow in unprecedented detail – showing how myeloma behaves differently in each patient. A step toward personalised blood cancer treatment.

πŸ”— www.wehi.edu.au/news/rethink...

@bloodjournals.hematology.org

17.08.2025 23:10 πŸ‘ 10 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1

Would you pay $150 per article to post your preprint on @bioRxiv @aRxiv @medRxiv @chemRxiv etc.? Currently it’s free but a small cost could help offset running costs and also work as a barrier against paper mills and AIs just posting all the time and filling these sites up.

09.07.2025 18:03 πŸ‘ 88 πŸ” 19 πŸ’¬ 25 πŸ“Œ 5
Loss of MCL-1 triggers severe mitochondrial damage (shown in the right panel). Mitochondria are shown in red, cell nuclei in blue.

Loss of MCL-1 triggers severe mitochondrial damage (shown in the right panel). Mitochondria are shown in red, cell nuclei in blue.

New research: MCL-1 not only prevents cell death, also fuels cells by supporting energy production. Helps explain side effects seen with MCL-1 targeting drugs in cancer clinical trials; could lead to better therapies. In @science.org

πŸ”— www.wehi.edu.au/news/hidden-...

08.07.2025 03:21 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 1
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Today is June 25. On this date in 1903 Marie Curie defended her doctoral thesis on radioactive substances at UniversitΓ© de la Sorbonne in Paris, becoming 1st woman in France to receive a doctoral degree. Image shows the thesis cover.

25.06.2025 06:01 πŸ‘ 94 πŸ” 31 πŸ’¬ 0 πŸ“Œ 3
Barbara McClintock portrait

Barbara McClintock portrait

🧬🌽 Happy Transposon Day! 🌽🧬

Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025

16.06.2025 15:14 πŸ‘ 479 πŸ” 192 πŸ’¬ 5 πŸ“Œ 10

I showed my wife the graphic (which I fele is distressingly effective) and she made it worse...

"It looks like an apoptotic cell"

2/2

24.05.2025 22:23 πŸ‘ 60 πŸ” 3 πŸ’¬ 5 πŸ“Œ 0
Innate lymphoid cells 3 (ILC3s) are a subset of immune cells that are critical to gut immunity.β€―When there is excess fat, such as after a rich meal, ILC3s store this fat in tiny lipid droplets to maintain their function. In this 3D illustration, we can see a lipid droplet (in orange) inside an ILC3.

Innate lymphoid cells 3 (ILC3s) are a subset of immune cells that are critical to gut immunity.β€―When there is excess fat, such as after a rich meal, ILC3s store this fat in tiny lipid droplets to maintain their function. In this 3D illustration, we can see a lipid droplet (in orange) inside an ILC3.

A landmark WEHI-led study has uncovered how our daily food choices are having an immediate effect on our gut health.

Brilliant research led byDr Cyril Seillet and Dr Le Xiong, that could help pinpoint #chronicinflammation at the source. Now published in Immunity.

www.wehi.edu.au/news/fast-fo...

19.05.2025 01:41 πŸ‘ 9 πŸ” 6 πŸ’¬ 0 πŸ“Œ 1
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LoxCode in vivo barcoding reveals epiblast clonal fate bias to fetal organs Much remains to be learned about the clonal fate of mammalian epiblast cells. Here, we develop high-diversity Cre recombinase-driven LoxCode barcoding…

A triumph of perseverance from twitterless Tom Weber, Christine Biben and the team, our in vivo barcoding "LoxCode mouse" used to resolve epiblast fate to fetal organs is finally published in @cellpress.bsky.social and available through @jacksonlab.bsky.social www.sciencedirect.com/science/arti...

16.05.2025 04:32 πŸ‘ 71 πŸ” 22 πŸ’¬ 8 πŸ“Œ 1
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Make your future Melbourne Lead the next wave of biomedical discovery

🌏 Make your mark in Melbourne! 🌏 We are looking for innovative researchers to join WEHI as Laboratory Heads and help lead the next wave of biomedical discovery.

For more information and to apply πŸ‘‡

15.05.2025 07:03 πŸ‘ 10 πŸ” 7 πŸ’¬ 0 πŸ“Œ 4
Four images to illustrate some prominent single-gene myths. Top left shows a photograph of a person deftly rolling their tongue into a U-shape. Top right shows a photograph of a person’s ear, highlighting the shape and features of the earlobe and cartilage. Bottom left shows a close-up photograph of a person’s eye, with a vivid blue colouration. Bottom right shows a photograph of a person poised to write with their left hand on the blank white page of a spiral-bound notebook.

Four images to illustrate some prominent single-gene myths. Top left shows a photograph of a person deftly rolling their tongue into a U-shape. Top right shows a photograph of a person’s ear, highlighting the shape and features of the earlobe and cartilage. Bottom left shows a close-up photograph of a person’s eye, with a vivid blue colouration. Bottom right shows a photograph of a person poised to write with their left hand on the blank white page of a spiral-bound notebook.

Remember when you first learned about genetics at school? All those fascinating examples of human traits that are each apparently determined by just a single gene? Time to check in on some of your favourites to see how they’re doing. 🧬🧡πŸ§ͺ 1/n

02.05.2025 14:50 πŸ‘ 1271 πŸ” 594 πŸ’¬ 51 πŸ“Œ 84

Remove a letter, ruin a movie.

Seeping Beauty

02.05.2025 22:33 πŸ‘ 475 πŸ” 35 πŸ’¬ 286 πŸ“Œ 183
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Researchers WEHI and Duke-NUS Medical School have uncovered another important role of protein MCL-1: it keeps hair growing!

A finding that could pave the way for new treatments for alopecia, hair loss.

Read the study in Nature Communications: www.nature.com/articles/s41...

25.03.2025 23:26 πŸ‘ 8 πŸ” 4 πŸ’¬ 0 πŸ“Œ 1

Many congratulations @kaiming-li.bsky.social @dewsonlab.bsky.social

01.04.2025 06:06 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Final version of our paper on targeting BAK / BAX to modulate apoptosis is out✌️! Can't wait to see where these tool compounds can be usedπŸ’Š. Honour to work in this team with screening scientists, chemists, biologists & more @dcshuang.bsky.social @dewsonlab.bsky.social @wehi-research.bsky.social

29.03.2025 09:10 πŸ‘ 2 πŸ” 2 πŸ’¬ 2 πŸ“Œ 0
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Scientists solve decades-long Parkinson’s mystery WEHI researchers have made a huge leap forward in the fight against Parkinson’s disease, solving a decades-long mystery that paves the way for development of new drugs to treat the condition.

World-first: researchers have discovered what protein #PINK1 looks like in humans and how it is activated, solving a decades-long mystery in the fight against #Parkinsonsdisease. The team hope to use the knowledge to find a drug to stop #Parkinsons.

www.wehi.edu.au/news/scienti...

13.03.2025 21:58 πŸ‘ 47 πŸ” 17 πŸ’¬ 1 πŸ“Œ 1
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Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social

13.03.2025 19:19 πŸ‘ 168 πŸ” 56 πŸ’¬ 8 πŸ“Œ 6