Shunya Ohmura

Very proud on our stellar Alina Ritter for her frist first-author paper:

Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances #chemotherapy efficacy in #Ewing #sarcoma

tinyurl.com/3kcs3bc9

@dkfz.bsky.social
@uniheidelberg.bsky.social
@nct-heidelberg.bsky.social

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway The APOE3 Christchurch mutation (R136S) reduces tau pathology despite the PSEN1 mutation and high amyloid, though its protective mechanism remains unclear. Naguib et al. show that R136S suppresses mic...

"A rare genetic mutation known as APOE3-R136S, or the “Christchurch mutation,” appears to protect against #AlzheimersDisease by suppressing inflammatory signaling in the brain’s immune cells."

Learn More in Immunity @cellpress.bsky.social
www.cell.com/immunity/abs...

EWSR1::ETS-low cells promote metabolic reprogramming of the tryptophan-kynurenine-AHR axis, immunosuppression, and poor outcome in Ewing sarcoma https://www.biorxiv.org/content/10.1101/2025.05.16.654502v1

Taurine from tumour niche drives glycolysis to promote leukaemogenesis - Nature The taurine–taurine transporter axis is a critical dependency of aggressive myeloid leukaemias.

www.nature.com/articles/s41...

Folkert, Molina Arocho, Haldar et al. show that iron-rich tumor-associated #macrophages promote #angiogenesis and #immunosuppression in tumors. rupress.org/jem/article/...

📘 In our #Immunometabolism 2025 collection: rupress.org/jem/collecti...

Adaptive NK Cells Exhibit Tumor-Specific Immune Memory and Cytotoxicity in Ovarian Cancer url:https://aacrjournals.org/cancerimmunolres/article/doi/10.1158/2326-6066.CIR-24-0852/762019/Adaptive-NK-Cells-Exhibit-Tumor-Specific-Immune

Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors Metallophilic marginal zone macrophages are positioned strategically within the spleen to process internalized blood-borne materials. Mauvais et al. find that these CD169+ macrophages cross-prime CD8+ T cell responses to internalized antigens using a proteasome-independent pathway, contributing to antitumor immunity independently of type 1 conventional dendritic cells.

Online now: Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors

The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @science.org 🎉
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩‍🎨

So proud on our stellar medical student Florian H. Geyer for his first first-authorship paper!

Comprehensive #DSRCT multi-omics analyses unveil CACNA2D2 as a diagnostic hallmark and super-enhancer-driven EWSR1::WT1 signature gene
tinyurl.com/42fxmmud

@dkfz.bsky.social
@uniheidelberg.bsky.social

Only 4 days left to register. I hope to see many new ferroptosis researchers in Chicago!

Targeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitors Tumor cells often cope with elevated levels of replication stress (RS) causing increased dependency on ATR-CHK1 signalling. We previously presented RRM2, the regulatory component of the ribonucleotide...

Combinatory RRM2 and CHK1 targeted therapy
www.biorxiv.org/content/10.1...