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@lealescouzeres

Post-doc in Patten Lab πŸ‡¨πŸ‡¦ #zebrafish #neurodegenerative diseases 🧠🐟

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Latest posts by @lealescouzeres

This work is the result of a fantastic collaboration over the past few years in Montreal between the Patten lab at @inrsciences.bsky.social , The Neuro's EDDU (Early Drug Discovery Unit) @theneuro.bsky.social , and the group of Antoine Dufour @ucalgary.bsky.social 🧬

12.12.2025 15:24 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Therapeutic modulation of the calpastatin/calpain pathway restores calpain-mediated synaptic proteolysis and preserves motor neurons survival and function in C9orf72 ALS A hexanucleotide repeat expansion (GGGGCC) in the C9orf72 gene is the most prevalent genetic cause of ALS, with early neuromuscular junction (NMJ) dysfunction being a key pathological feature. Current...

πŸŽ‰ Excited to share our latest preprintπŸ“° !
www.biorxiv.org/cgi/content/...
Many thanks to everyone involved in this project ! Using a zebrafish model 🐟 and iPSC-derived motor neurons πŸ”¬ we show that restoring the calpastatin/calpain pathway preserves motoneuron survival and function in C9orf72 ALS!

12.12.2025 15:21 πŸ‘ 13 πŸ” 8 πŸ’¬ 1 πŸ“Œ 0