Ricardo Mallarino's Avatar

Ricardo Mallarino

@mallarinolab

Associate Professor at Princeton University studying development, genetics, evolution, and everything in between. πŸ¦‡πŸ¦†πŸ¦˜πŸΏοΈπŸ…πŸ¦Ž www.mallarinolab.org

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17.10.2025
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Latest posts by Ricardo Mallarino @mallarinolab

If Bad Bunny can cover the history of Puerto Rico, colonialism, transatlantic slavery, hemispheric consciousness, as well as contemporary life and politics in under 14 minutes, you can do your 15- or 20-minute conference presentation with time to spare.

09.02.2026 23:56 πŸ‘ 3011 πŸ” 609 πŸ’¬ 51 πŸ“Œ 86
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Cell Type-Specific Hormonal Signaling Configures Hypothalamic Circuits for Parenting Parenting behavior emerges from hormonally sensitive circuits, but how distinct circuit components are affected by, and contribute to, sex and state dependent changes in infant caregiving remains uncl...

New paper alert!!...🀩 Led by @blogeman.bsky.social, we identify how cell type-specific hormonal responses in the hypothalamus tunes parenting behavior in males and females 🐭🧠🍼. Highlights in thread πŸ‘‡ 1/6

www.biorxiv.org/content/10.6...

13.12.2025 14:01 πŸ‘ 73 πŸ” 32 πŸ’¬ 1 πŸ“Œ 0
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Rapid compensatory evolution within a multiprotein complex preserves telomere integrity Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...

How to keep in step when your (protein) partner speeds up…

Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.

Congrats to whole team!

www.science.org/doi/10.1126/...

28.11.2025 17:22 πŸ‘ 120 πŸ” 64 πŸ’¬ 6 πŸ“Œ 4

This is amazing - congrats, Mia and team!!

28.11.2025 18:40 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals Host body temperature can define a virus’s replicative profileβ€”influenza A viruses (IAVs) adapted to 40Β° to 42Β°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...

How does fever work?

Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.

This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧡

www.science.org/doi/10.1126/...

27.11.2025 19:55 πŸ‘ 200 πŸ” 90 πŸ’¬ 6 πŸ“Œ 6

As a longtime fan of cool papers in @currentbiology.bsky.social, I am really thrilled to see this out!

This study sets the stage for understanding the origins of novel (vocal) behaviors.

Big shout out to the main architects of this work @xmikezheng20.bsky.social and @cliffscience.bsky.social

19.11.2025 18:42 πŸ‘ 56 πŸ” 23 πŸ’¬ 8 πŸ“Œ 1
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SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT

19.11.2025 20:23 πŸ‘ 119 πŸ” 75 πŸ’¬ 1 πŸ“Œ 3
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Niche-specific dermal macrophage loss promotes skin capillary ageing - Nature Capillary-associated macrophages are selectively lost over time, contributing to impaired vascular repair and reduced tissue perfusion in older mice.

When Macrophages Disappear, Skin Blood Vessels Age!
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
πŸ‘‡πŸ‘‡
www.nature.com/articles/s41...

15.10.2025 15:52 πŸ‘ 22 πŸ” 12 πŸ’¬ 6 πŸ“Œ 0
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Insertion of an invading retrovirus regulates a novel color trait in swordtail fish For over a century, evolutionary biologists have been motivated to understand the mechanisms through which organisms adapt to their environments. Coloration and pigmentation are remarkably variable wi...

I am so excited to share new work on a TE insertion that regulates iridescence in swordtails, led by fantastic grad student @nadiahaghani.bsky.social and with help from many coauthors! In a time that has been so difficult to navigate, this & other projects have kept my spirits up: shorturl.at/NE65A

12.11.2025 20:34 πŸ‘ 186 πŸ” 69 πŸ’¬ 3 πŸ“Œ 15

I’d given up on social media, but I was missing too many cool papers. Case in point: this incredible new study from @cagricevrim.bsky.social and @karalmckinley.bsky.social. Simply amazing!

12.11.2025 18:29 πŸ‘ 11 πŸ” 5 πŸ’¬ 2 πŸ“Œ 0

A fascinating new study in which the humble sugar glider makes a special appearance, helping a team led by @brainevodevo.bsky.social and @fennak.bsky.social uncover the evolutionary history of a group of inhibitory neurons. Check out this thread summarizing the main findings!

12.11.2025 18:19 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1