Pls re-post: My department @oxfordbiochemistry.bsky.social are recruiting for several new faculty positions (links below). Broad search in molecular biology/biochemistry, across prokaryotes and eukaryotes. Interested in understanding life at the molecular level, this job might be for you!
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I had a lot of fun putting this together with @suminkim.bsky.social and @andersshansen.bsky.social! Glad to have had the chance to work on it!
Come to hear Alan's great new story on SET1/MLL proteins and transcription next Wednesday. @fnucleosome.bsky.social
Unbelievably, #DuvetKnowItsChristmas generates such good will on social media that over the years we've raised somewhere approaching a quarter of a million quid for homeless charities. If you can spare a bob or two, sling some to Centrepoint, and here's the link: www.gofundme.com/f/duvet-know...
Shout-out to @fairbanc.bsky.social for letting me sleep in her house and hang out with her cat
This year I'm hosting Christmas in my 1-bed flat. My brother has inherited last year's airbed setup and I've upgraded to an actual bed!
Just a (freezing) 10-minute cycle down the road to my friend's house to get to it...
I get to hang out with Imogen though so I'm still happy
#DuvetKnowItsChristmas
Excited to share our new preprint from the Klose lab, where we investigate how SET1/MLL complexes shape H3K4me3 and regulate transcription in mouse ES cells. www.biorxiv.org/content/10.6...
Very proud to have our latest work now online in
@natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4
www.nature.com/articles/s41...
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 20/31
Prompt RIVALS
Pdb: 8V27 & 8G6S
Two rival histone modifications on a nucleosome. Ubiquitination of H2BK120 activates genes while H2AK119 represses them.
Next: BLAST
Suggestions?
Time to talk about one of my favourite Oxford buildings, 26-27-28 Cornmarket!!
Popularly known as The Old Pret
If you're looking for Oxford local news that actually reports local news, the Oxford Clarion is worth a follow and subscribe!
Who can work in science, EVERYONE #pride
EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!
🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome
RNA xkcd.com/3056
Research @oxfordbiochemistry.bsky.social @ox.ac.uk supported by the Wellcome Trust (UK) and NIH (USA) reveals essential new player in the process of deciding whether genes should be made or not. Great work @jesskelley.bsky.social
@robklose.bsky.social @edimitrova.bsky.social 👏 bit.ly/202502-klose
Please could you correct the spelling on my tag in this? I'm sure Jess Kelly doesn't want the random notifications either!
@bencarty.bsky.social and the team did a fantastic job in a wonderful collaboration with @naltemose.bsky.social as well as Dani Fachinetti and Simona Giunta’s teams to help define the molecular basis for maintaining centromeric chromatin size and position. www.biorxiv.org/content/10.1...
I love scientists
Two photos of Anna, a young white woman using an electric wheelchair, wearing a blue lab coat that fits her well with tables and dry-lab equipment in the background. Text reads: "A team of researchers and designers led by UCL is looking for wheelchair users working in wet lab environments to user-test what is believed to be the first-ever prototype of a lab coat adapted for wheelchair users."
Do you know a UK-based wheelchair user who works in a lab and would be willing to user-test our prototype of what is believed to be the first-ever lab coat adapted for wheelchair users?
Please share far & wide! Interest form: forms.office.com/e/66FhcQjqRT
More info: www.ucl.ac.uk/ucl-east/new...
So I'll be back around then. We'll be trying to raise a bit of money for Centrepoint, bearing in mind that there are a bunch of people who have nowhere to go this evening. gofund.me/637d21d0 ENDS FOR NOW 🎄🛏️
Photo of an airbed set up with a sleeping bag and pillows, on the floor in front of a TV and Christmas tree. There is a two-seat green sofa and a grey folding camping chair around it.
I finally get to join an honoured festive tradition in #DuvetKnowItsChristmas
Parents are stopping over in my 1-bed flat before we go join the family gathering in the morning. They get my bed, I get the airbed on my own living room floor.
Also featuring camping chair to supplement my 2-seat sofa
This title if the comic is ‘Googling Stuff…’ The comic shows two columns: on the left is “Then” showing search results with one thing listed as “the thing you want” On the right column is ‘Now’ - also showing search results but in this case it’s a whole bunch of stuff you don’t need: AI TAKING A WILD STAB AT IT WITH SOME BLATANT MISINFORMATION SPONSORED RESULT SPONSORED RESULT SPONSORED RESULT SPONSORED RESULT PEOPLE ALSO ASK VIEW PRODUCTS And then right at the bottom just off screen is ‘the thing you want’
Googling Stuff: Then v Now.
We have had multiple discussions about why people have not previously observed the very dramatic reduction in transcription upon PNUTS depletion. So I looked at our own TT-seq data and analysed it without including the spike-in. The numbers speak for themselves! Spike-in calibration is important!
Join Oxford Biological Physics! #KavliOxford is inviting applications for Fellows to establish independent research groups in this dynamic, interdisciplinary field. Apply now: kavli.web.ox.ac.uk/article/2025...
Turns out that, for me, news sites are a great way to become usefully informed about what's happening in the world, and Twitter is a great way to get uselessly stressed about it.
Thank you! We had an amazing team on this project with everyone contributing their own unique expertise to tackle a tricky problem!
Nice thread collating all these exciting new reviews! My 'to read' list has definitely just got even longer...
On the reading list
This paper is genuinely amazing! Not only is the science very cool, it is also a masterclass in scientific writing, as are most @robklose.bsky.social lab papers!
