Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia Reduced levels of the essential metabolite heme are a common feature of acute myeloid leukemia, and consequently, leukemic cells are highly sensitive to inhibition of de novo heme synthesis. Blockade ...

Heme biosynthesis is a really fascinating pathway. We think targeting the enzymes that make heme is a really promising strategy for AML. Check out our paper online today in @cellpress.bsky.social @petermaccc.bsky.social

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