Atsushi Yoshida

Beyond the Brake: the Subthalamic Nucleus Predominantly Facilitates Action in Non-human Primates The subthalamic nucleus (STN) is traditionally viewed as a brake on motor output. Challenging this model, we investigated its role in value-based decision-making by recording single-neuron activity fr...

www.biorxiv.org/content/10.6...

Excitatory drive to the globus pallidus external segment facilitates action initiation in non-human primates The globus pallidus external segment (GPe) is traditionally viewed as a brake on motor output. In this article, Yoshida and Hikosaka show distinct neural populations within the primate GPe that, in fa...

www.cell.com/current-biol...

Contribution of glutamatergic projections to neurons in the nonhuman primate substantia nigra pars reticulata for reactive inhibition | PNAS The basal ganglia play a crucial role in action selection by facilitating desired movements and suppressing unwanted ones. The substantia nigra par...

Contribution of glutamatergic projections to neurons in the nonhuman primate substantia nigra pars reticulata for reactive inhibition | PNAS www.pnas.org/doi/10.1073/...

How the brain hits the brakes on our actions Our brain's action gatekeeper, the SNr, uses single neurons to both facilitate 'go' and suppress 'stop' commands. We found this 'stop' function is causally driven by an excitatory glutamate input, whi...

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Excitatory drive to the globus pallidus external segment facilitates action initiation in non-human primates The external segment of the globus pallidus (GPe) has conventionally been regarded as a key relay in the indirect pathway of the basal ganglia, primarily mediating movement suppression; however, recen...

www.biorxiv.org/content/10.1...

Contribution of glutamatergic projections to neurons in the nonhuman primate lateral substantia nigra pars reticulata for the reactive inhibition The basal ganglia play a crucial role in action selection by facilitating desired movements and suppressing unwanted ones. The substantia nigra pars reticulata (SNr), a key output nucleus, facilitates...

www.biorxiv.org/content/10.1...

Involvement of Neurons in the Nonhuman Primate Anterior Striatum in Proactive Inhibition Behaving as desired requires selecting the appropriate behavior and inhibiting the selection of inappropriate behavior. This inhibitory function involves multiple processes, such as reactive and proac...

www.jneurosci.org/content/44/4...