RoseMarie Akiki

An honor to have such great mentors @makototaniguchi.bsky.social and Dr. Cowan! Very proud to be an alumna from their labs!

A long noncoding eRNA forms R-loops to shape emotional experience–induced behavioral adaptation Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations are...

Our study, led by @rosemarieakiki.bsky.social, reveals how long non-coding RNAs translate emotional experience into immediate early gene expression through R-loops and 3D chromatin loops.

www.science.org/doi/10.1126/...

An Epigenetic Mechanism Promoting Heroin Relapse After Prolonged Abstinence

Check out our commentary on Mitra et al.'s findings in Biological Psychiatry on an epigenetic mechanism promoting heroine relapse after prolonged abstinence www.sciencedirect.com/science/arti...

I owe it all to Lebanon ❤️

A neuronal gene that loops the loop Noncoding RNA controls the expression of a gene implicated in drug- and stress-induced behaviors

Noncoding RNA controls the expression of a gene implicated in drug- and stress-induced behaviors.

Learn more in a new #SciencePerspective:

It's like someone read my mind!

RNA:DNA 'sandwich' plays key role in behavioral adaptations arising from emotional experiences, research reveals A team of neuroscience researchers at the Medical University of South Carolina reports in Science the discovery of a new genetic regulatory mechanism involved in behavioral adaptations to emotional experiences in a preclinical model.

A genetic regulatory mechanism involving RNA:DNA structures plays a crucial role in behavioral adaptations to emotional experiences, potentially informing RNA-based therapies for psychiatric disorders. doi.org/g8vf5f

I definitely have the best and most supportive committee out there!

A long noncoding eRNA forms R-loops to shape emotional experience–induced behavioral adaptation Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations are...

Following @daylab.bsky.social’s nice paper on eRNA regulating Fos, and then our paper showing eRNA mediated regulation of NR4A2, here’s yet another eRNA controlling NPAS4.

LncRNAs for the win in the brain!

www.science.org/doi/10.1126/...

Great perspective on our paper by Dr. Heller looping our findings to modern molecular neuroscience!