Sasha Meek

🌋 Ring of power: Seven exocysts form a flexible ring structure that pulls #Yeast secretory vesicles to the plasma membrane. Vesicles move stepwise from 45nm to 5nm to the PM in three metastable steps, revealing the mechanics of exocytosis

🧬 #YeastResearch #SGD
www.yeastgenome.org/reference/S1...

Check out 🧐 our new preprint 📜:
www.biorxiv.org/content/10.1...
Congrats🎉 to @vasilgaisin.bsky.social and Corina Hadjicharalambous, who studied contractile injection systems directly in hot spring♨️ bacterial mats🦠
#microsky #teamtomo #Chloroflexota

The abstract submission deadline for our upcoming 'Imaging Cell Dynamics' meeting is this Friday. We still have a few places remaining so apply now to secure your spot!

Find out more at:
www.biologists.com/meetings/jcs...

#imaging #microscopy #cellbiology

Very happy that our "ExHOS in action" was selected! Thanks a lot @prbb.org , credit goes to Dylan Godfrey🙌

Check out our new paper on exocytosis continuum architecture!! Only an incredible and multidisciplinary team made this possible.

Descobreixen el nanomissatger que manté les cèl·lules en funcionament Es tracta d’una petita màquina que lliura paquets moleculars essencials a la superfície cel·lular, una activitat fonamental per mantenir la salut de les cèl·lules. Aquest enigmàtic mecanisme s'ha pogu...

#Research
1/📦 Scientists uncover the tiny machine that delivers essential molecular packages to the cell surface

This fundamental activity for maintaining healthy cells has been revealed by combining cutting-edge microscopy techniques and artificial intelligence
www.upf.edu/web/focus/w/...

De novo designed bright, hyperstable rhodamine binders for fluorescence microscopy De novo protein design has emerged as a powerful strategy with the promise to create new tools. The practical performance of designed fluorophore binders, however, has remained far from meeting fluore...

Preprint drop! 🚨 Rhobin-tag your proteins and watch Saci glow at high temps! 🔥 Bright, photostable, live-cell imaging made possible with JF dyes. Huge thanks to @samjlord.bsky.social @acharlesorszag.bsky.social @mullinslab.bsky.social and Bo Huang lab at UCSF.😊

www.biorxiv.org/content/10.1...

#membrane seminars are back this THURSDAY for a super session with @dr-downes.bsky.social from the @giuliazanetti.bsky.social lab and Xin Zhou from the Ikonen lab! @felixmendu.bsky.social @ishier.bsky.social

Another year in OpenPRBB, always so nice to talk about science and show our lab 🥹🧑‍🔬 #openprbb2025

Please share🙌🤗
We just opened a PhD position to investigate biophysics in eukaryotes that grow in the cryosphere (glaciers, snow, Mars....)! If you like advanced imaging, evolution and quantitative biology, apply!! we are looking for you! More details here👇
www.upf.edu/documents/28...

Incredible experience working with such a great team of researchers!! Check out our preprint on the continuum architecture of exocytosis.

Nice preprint from @gallegolab.bsky.social!
Bridging static structures of exocyst with dynamic function provides really interesting flexible, ring-shaped higher-order exocyst structure (ExHOS).

Continuum architecture dynamics of vesicle tethering in exocytosis
www.biorxiv.org/content/10.1...