New preprint! We investigate the risk of algorithmic bias (across race/ethnicity, gender, and their intersection) in machine learning models predicting suicide attempts across 3 clinical settings in over 1.2 million patients.
osf.io/preprints/ps...
Our multi-ancestry GWAS of EXTernalizing conditions (ADHD, substance use...) in ~4M people reveals neurodevelopmental risk, drug-repurposing targets, and yields one of the strongest psychiatric polygenic indices yet! 🧬🎉 doi.org/10.64898/202...
4/4 A HUGE 🙏thank you to the @pgcgenetics.bsky.social working groups and participants and amazing co-authors, with special shoutout to Josefin Werme, Wouter Peyrot, Alex Frei, Christiaan de Leeuw, Lucy Bicks, Ken Kendler, and @jorsmo.bsky.social. This work reflects collaboration at its best ❤️🧬
Another great post from @sashagusevposts.bsky.social "The mystery of twin heritability comes to an ignoble end: no massive tranche of rare variants, no phantom interactions, just inflation."
theinfinitesimal.substack.com/p/the-missin...
***3 days left to sign up for our virtual conference on Precision Psychiatry***
+CME +free for students and trainees.
Featuring an amazing line-up of speakers.
New article written by Heather Stringer about precision treatment work in the mental health space by Kate Bentley, Ellen Driessen, @jorsmo.bsky.social, Leanne Williams, Conor Liston, and others www.apa.org/monitor/2025...
Ending the federal LGBTQ+ suicide prevention line is a public health failure www.statnews.com/2025/07/12/e... via @statnews.com
The Surprising Scientists Hit by Trump’s D.E.I. Cuts www.nytimes.com/2025/07/10/u...
Twin study suggests genetic variation influences how funny you think you are but not how funny you actually are. 😄
www.cambridge.org/core/journal...
New polygenic score resource from Mykyta Artomov and colleagues and @finngen.bsky.social
"All data and predictive tools are accessible via the PGS Browser (pgs.nchigm.org), an interactive web-based platform for PGS analysis and interpretation."
www.medrxiv.org/content/10.1...
"career staff were told not to respond in writing to panicky grant recipients whose funding had been shut off to avoid a “paper trail,”
wapo.st/4kjmqsn
🆕📽️Last week's webinar is available now on YouTube!
How to Help a Loved One Struggling with Suicidal Thoughts and Behaviors youtu.be/TMCAikdy2dQ?...
Thank you to everyone who joined, our speakers, moderator, @jorsmo.bsky.social & @matnoc.bsky.social @afspnational.bsky.social
the disturbing old days of medicine and psychiatry in this episode of Medic from 1956:
ulcerative colitis is caused by deep seated personality problems youtu.be/jki-rT92Uog
From back in the day when a two page research paper with no tables or references could still be transformative?
Sad to see this. I used to love these numbers when I was a kid
Reviewer #2 is now soliciting articles.
🚨🧬 New preprint! We tested whether PGS predicted global functioning across psychiatric hospitalization among 5991 people with schizophrenia. medrxiv.org/cgi/content/...
New Forbes story about the economic consequences of science cuts.
www.forbes.com/sites/johndr...
Thoughtful and thorough analysis.
1/n
Another breakthrough made possible by federal funding The result “is a triumph for the American peoples’ investment in biomedical research”
Baby Is Healed With World’s First Personalized Gene-Editing Treatment www.nytimes.com/2025/05/15/h...
"let’s be clear: It isn’t institutions that are being punished. It’s the researchers who are the future of science in this country"
What am I supposed to say to this generation of young scientists? www.statnews.com/2025/05/07/u... via @statnews.com
75% of US scientists who answered Nature poll consider leaving www.nature.com/articles/d41...
New work led by Yi-Han Sheu providing continuous-time and dynamic risk prediction models using Neuro-ODE with application to suicide risk prediction rdcu.be/eeIte
JAMA 100 yrs ago: "it is generally recognized that men with large heads seem to represent the intelligentsia of man, although this does not mean necessarily that a smaller headed man may not be quite as keen in his intellectual processes."
Large and Small Brains jamanetwork.com/journals/jam...
We Need a Reminder of What the Pre-Vaccine Era Was Like www.nytimes.com/interactive/...
How the NIH dominates the world’s health research — in charts www.nature.com/articles/d41...
Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41...
(feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)
Great thread Paul. This comment in particular caught my eye--I had never thought to calculate this in planning for lab's funding but its very helpful (and daunting since this is the status quo and as you suggest, things may get much harder).
