Congratulations to Dr. Katerina Kiriakopulos and all co-workers! Tremendous efforts finalize a great story about a lncRNA driving a really important biological process.

CISTR’s DNA and RNA have function. NuRD complex components bind CISTR’s locus, whilst transcription factor FOSL2 associates with CISTR’s RNA. In CISTR’s absence, FOSL2 is misguided which leads to differential regulation of cell morphogenesis genes and aberrant cell size.

CISTR-ACT maintains cell size across cell types in human and mice by regulating cell morphogenesis genes in trans via guidance of the transcription factor FOSL2.

CISTR-ACT was the 1st lncRNA involved in inter-chromosomal contacts and in Mendelian disease (brachydactyly). We now revealed CISTR-ACT’s molecular mechanism: tinyurl.com/CISTR-ACT, @sickkidsto.bsky.social, @uoftpress.bsky.social, @natcomms.nature.com, @natureportfolio.nature.com

tRNA-overlapping long non-coding RNA loci repress codon-biased genes Ahmed et al. define tRNA-overlapping lncRNAs (tROLs). tROLs in gene-dense regions interact between chromosomes and depend on each other’s transcription. tROL perturbations silence codon-biased genes i...

📢 Paper Alert: tinyurl.com/yzy2d864. We characterized tRNA-overlapping lncRNA loci = tROLs! tROL perturbations silence
codon-biased genes in inter-chromosomal proximity. tROLs bridge the non-coding
and coding genomes. @sickkidsto.bsky.social @uoftpress.bsky.social

Register now and see you soon in Mexico for a great conference and speaker line up!

Inter-chromosomal contacts demarcate genome topology along a spatial gradient - Nature Communications The authors develop a supervised and unsupervised learning algorithm Signature. Machine learning and network model analysis of Hi-C datasets across 62 2n genomes suggest that inter-chromosomal contact...

Finally, the Maass lab is on #Bluesky and seeks science skeets and news! More on lncRNAs and trans-chromosomal contacts (kissing chromosomes / non-homologous chromosomal contacts [NHCCs] soon. Refreshing some older news: www.nature.com/articles/s41...