#JEMLegacy @jem.org goes back to 1930 with the first description by William Tillett and Thomas Francis Jr. of C-reactive protein (CRP) in the sera of patients during the acute phase of pneumococcal pneumonia.
@RockUPress @RockefellerUniv
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Happy Thanksgiving to all who celebrate! This #JEM_Spotlight highlights a study by George Fu Gao et al. that provides insight into how #Coxsackievirus, a common cause of childhood hand-foot-and-mouth disease (#HFMD), induces #onychomadesis (nail shedding).
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Another excellent #Viewpoint! Thank you to our contributors @priyadevarajan.bsky.social, @rzappasodi.bsky.social, Novalia Pishesha, Jui-Hsia Weng, Kate Alexander, Yadira Soto-Feliciano, and @kedmiranit.bsky.social ✨
In light of Monday’s #Nobel Prize in Physiology or Medicine announcement, for #JEMLegacy let’s look back at one of Shimon Sakaguchi’s early @jem.org papers from 1985! rupress.org/jem/article/...
And if you needed any more convincing about the importance of #Tregs, check out this #Viewpoint written by Shimon for @jem.org's 125th anniversary about the role of Tregs in immunological self-tolerance and autoimmunity 👉 rupress.org/jem/article/...
Please also check out the video by Dr. Phil Gold describing the discovery👇
www.youtube.com/watch?v=UVB8...
This #JEMLegacy tweet highlights two papers from 1965 by Drs. Phil Gold and Samuel O. Freedman @mcgill.ca on the discovery of the Carcinoembryonic Antigen (CEA), the basis for the widely used CEA blood test.
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#cancer #biomarker #CEA
#WomenInSTEM becoming independent: People should feel free to be themselves and do great science. We asked ten women researchers about their science and the process of setting up a lab as an independent researcher: rupress.org/jem/article/...
📢 We're now accepting applications for the JEM Early Career Travel Award, for grad students & early-career postdocs to participate in a scientific conference! This year, the award will support the attendance of #Cytokines2025 @cytokinesociety.bsky.social! Apply here 👉 rupress.org/jem/pages/ea...
Similar studies were published around the same time in PNAS @PNASNews by Dr. Bali Pulendran (doi.org/10.1073/pnas...) and in Science @ScienceMagazine by Dr. Yong-Jun Liu (www.science.org/doi/10.1126/...).
This #JEMLegacy tweet takes you to a 1999 study by Dr. Muriel Moser that demonstrated the functional dichotomy between CD8a+ and CD8a- DCs in driving distinct T helper cell responses.
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#Immunology #DendriticCell #THelperCell
Check out this new study and TCR Tg mouse generated by Endi Santosa @endicytosis.bsky.social. If you are interested in studying classic and inflationary CD8+ T cell memory to MCMV infection, we’re happy to share this mouse, and @laboxenius.bsky.social is extremely generous with her Tg lines as well.
📢📢Published today in @jem.org 📢📢
New human inborn error of immunity.
We describe the first reported human with a monogenic disorder caused by the disruption of ZBTB7B, which encodes the transcription factor ThPOK.
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@ubcmedicine.bsky.social @bcchresearch.bsky.social
Our new #immunometabolism collection showcases research on the metabolic regulation of immune cells including CD8+ T cells, macrophages and neutrophils, tumor cells, and endothelial cells. Read new research to accompany @aegeanconf.bsky.social Int'l conference 👉
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Heading to ImmunoMetabolism conference. Looking forward to the talks and meeting with everyone there!
Attending #AAI2025 in Honolulu this weekend? Visit our booth #811 during the exhibit hours to chat about your latest research and learn about our journal! Don't forget to pick up a copy of the JEM Immunology collection (rupress.org/jem/collecti...) and take a souvenir 🎁 🏝️
In this review, Plata-Gómez & Ho discusses how aging and diet influence the metabolic reprogramming of the tumor–immune microenvironment, contributing to cancer progression and immune evasion. rupress.org/jem/article/...
📘 In our #Immunometabolism 2025 collection: rupress.org/jem/collecti...
Good morning #AACR25 attendees in Chicago! Come by our booth #3809 in the Exhibit Hall and chat about our journal and learn how @rupress.org journals are making publication experience easier! Pick up our latest #Cancer Collection magazine 📚 and an exclusive zip-up pouch 🎁
We're seeking a dynamic Executive Editor to lead @jem.org in NYC. Responsibilities include guiding journal strategy, managing an editorial team, engaging with researchers, and more. Apply here 👉 careers.rockefeller.edu/jobs/1743?la...
#STMjobs #LifeScienceJobs #PublishingJobs #ScienceJobs
Attending the Henry Kunkel Society's "Genes and Immunity" in Belgrade and interested in submitting your research to JEM? Meet our Deputy Editor @gaiajexpmed.bsky.social, who will be attending!
✉️ Email Gaia rupress.org/jem/pages/ed...
📘 See our collection rupress.org/jem/collecti...
#HKS2025
Our April issue is here! rupress.org/jem/issue/22...
The cover image represents the confocal imaging of periportal-venous fibroblasts in the liver of 8-wk-old Cd34creER;R26tdTomato mice. Fibroblasts are marked by CD34 (green) and Tomato (red). From Shan-Shan Wang et al.: doi.org/10.1084/jem....
We recently described the Axillary Lymphoid Organ (ALO) in the #Zebrafish. It's on the OUTSIDE of the fish, making it great for imaging! Learn more by checking out our paper in @jem.org rupress.org/jem/article-...
New: @zebrafish007.bsky.social, @zebrafishmk.bsky.social et al. #WeinsteinLab describe a previously uncharacterized external, experimentally accessible secondary lymphoid organ in the #zebrafish located above the pectoral fin. rupress.org/jem/article/...
Our latest @jem.org paper is out!
Radiotherapy induces GM-CSF in melanoma, driving monocytes to become regulatory monocyte-derived dendritic cells (moDCs)—traced with Ms4a3-TdTomato mice!
Huge shoutout to @Sirimuvva Tadepalli + @Derek Clements for leading this!
Thrilled to finally share our paper on how sex hormones and sex chromosomes interact to affect B cell class-switching!🥳 Diversity & inclusion in research recruitment = better science for all!😎 Thanks to @bcellsrosser.bsky.social@emmaschambers.bsky.social@arrdept-ucldom.bsky.social for ++ hard work!🌟
David Jackson @imm.ox.ac.uk discusses a new intravital imaging technique by Cleary et al. (rupress.org/jem/article/...) enabling lung lymphatics and their participation in immune cell trafficking events to be visualized for the first time in mechanically ventilated mice rupress.org/jem/article/...
Bauman, Snow et al. show that impaired T cell receptor–induced CARD11-dependent JNK signaling upregulates GATA3 & NFAT2, two key proteins in TH2 cell development, identifying a new mechanism by which CARD11 variants spur atopic disease. rupress.org/jem/article/...
De Sousa, Perkey, Le Corre, Maillard, Labrecque et al. @umontreal.ca show that fibroblastic reticular cells are the source of Notch ligands promoting the differentiation of short-lived effector CD8+ T cells. rupress.org/jem/article/...
#InfectiousDisease #HostDefense #LymphocyteBiology
Pestal, Slayden, and Barton demonstrate that group 2 KLF family transcription factors are critical for specifying the identity of distinct tissue-resident #macrophages. rupress.org/jem/article/...
Attending @keystonesymposia.bsky.social #KSTumorMetab25 in Vancouver? Get in touch with our Deputy Editor Cindy (Xin) Sun @cindy-jexpmed.bsky.social who will be in attendance and bring all your publication-related questions!
Check out our Tumor #Metabolism collection 👉 rupress.org/jem/collecti...
