Nick van Gastel

Selected speakers get free annual meeting registration, plus accommodation and travel allowance.

Abstract submission for the Mol Hem Workshop is now open here ehaweb.org/connect-netw...
Submit for your chance to present your latest unpublished work in a highly visible session that forms part of the EHA annual meeting program in Stockholm.

Register to attend the 2026 Mini Symposium! With featured presentations from Bethan Psaila, MBBS, PhD, Simón Méndez-Ferrer, PhD, Jian Xu, PhD, and selected abstracts, you won't want to miss this event!

Register👉️ iseh.org/Webinars-Eve...

Looking to hire a new position? Planning for your next career move? Register for the 2026 Virtual Career Fair!

Using a "speed networking " format, hiring faculty and potential candidates will have the chance to engage in one-on-one conversations. 🔗 iseh.org/Webinars-Eve...

New preprint from the lab! In this study we dive into the mechanisms that give #leukemia cells #metabolic plasticity, and how it differs from healthy hematopoietic cells. We discovered a process involving rapid changes in protein S-acylation unique to leukemia!

www.biorxiv.org/content/10.6...

Protein S-acylation dynamics provide metabolic plasticity to acute myeloid leukemia cells https://www.biorxiv.org/content/10.64898/2026.03.02.708949v1

Congrats to co-first authors Nithya Balasundaram & @aysegulerdemm.bsky.social & all co-authors. I started this study when in David Scadden’s lab, and want to thank him for his continued support! Funding from the Belgian Foundation against Cancer, F.R.S.-FNRS and Alex’s Lemonade Stand Foundation!

These discoveries originated from our finding that TOFA, a drug widely used to inhibit de novo lipogenesis, also inhibits protein S-acylation. This is a word of caution to other researchers using this drug, as it may inhibit many proteins using fatty acyl-CoA as substrate!

Healthy hematopoietic stem/progenitor cells in contrast have high intrinsic mitochondrial #flexibility, readily switching to other nutrients when glutamine breakdown is blocked. This shows that leukemia cells handle metabolic stress differently, creating a therapeutic opportunity!

Protein S-acylation is a post-translational modification in which fatty acids are covalently bound to proteins. When #glutamine catabolism is blocked, increased S-acylation of #mitochondrial proteins with long saturated fatty acids preserves metabolic health and leukemia cell survival.

New preprint from the lab! In this study we dive into the mechanisms that give #leukemia cells #metabolic plasticity, and how it differs from healthy hematopoietic cells. We discovered a process involving rapid changes in protein S-acylation unique to leukemia!

www.biorxiv.org/content/10.6...

⏱️ Two weeks remain to vote in the ISEH 2026-2027 Board of Directors election. All ISEH members are encouraged to participate. Review this year’s candidates and submit your ballot before 16 March: www.iseh.org/about/2026-Board-of-Directors-Election

Charting single-cell lineages with synthetic and natural barcodes - Nature Reviews Genetics In this Review, Rodriguez-Fraticelli and Parreno discuss advances in single-cell lineage-tracing methods and how their application to diverse biological processes, such as development, ageing and canc...

INTERESTED IN SINGLE-CELL LINEAGE TRACING?

Check our new review @naturerevgenet.bsky.social from the @alejofraticelli.bsky.social lab 🎉🎉

nature.com/articles/s41...

With Victoria Parreno, we tried to update the modern manual for genetic tracing and clonal analysis.

Read link: rdcu.be/e50gy

🚨 Only two days remain to submit an abstract for the 2026 Mini Symposium! Abstract submitters will have a chance to earn a symposium short talk, travel grant and #ISEH2026 🏙️ speaking slot.

👉️ iseh.org/Webinars-Eve...

This week on #SimplyBlood 🩸 we're sitting down with the 2026 ISEH Vice President Jennifer Trowbridge @trowbridgelab.bsky.social, to hear about upcoming work in her role, the benefits of the ISEH community, advice for trainees and much more➡️ iseh.org/Publications... @macnamaralab.bsky.social

🚨 NEW
@FraticelliLab
PREPRINT JUST WENT LIVE

biorxiv.org/content/10.6...

Here, we describe PLSTCs, Soluplus-based expansion cultures of primary mouse *Acute Myeloid Leukemia* Stem Cells. And then we use LARRY barcoding to identify drivers of leukemogenicity and drug resistance!

Aspartate availability drives differential engagement of the malate-aspartate shuttle Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent and can be modulated by the availability of the amino acid aspartate. In differentiated cells, malate-aspartate s...

A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/

The EAAT1 aspartate/glutamate transporter is dispensable for acute myeloid leukemia cell growth and response to therapy Acute myeloid leukemia (AML) is an aggressive malignancy of hematopoietic stem and progenitor cells characterized by profound metabolic dysregulation. Pyrimidine biosynthesis has emerged as a critical...

New paper from the lab! Acute myeloid #leukemia (AML) cells depend on nucleotide synthesis but blocking this pathway in patients comes with severe toxicity. We wondered if AML cells use EAAT transporters to take up aspartate, a key nutrient for nucleotide synthesis…
journals.plos.org/plosone/arti...

Funding by Fondation Contre le Cancer, F.R.S-FNRS, de Duve Institute and @uclouvain.bsky.social

Future work in the lab will explore alternative ways to starve #AML cells of aspartate to improve therapeutic options for patients! Congrats to first author Hernán Tirado and co-authors Nithya Balasundaram, Jean Jacobs @chamslab.bsky.social, Fleur Leguay and Lotfi Laaouimir!

While AML cells express EAAT1, the transporter was not needed for AML growth or survival after #chemotherapy, neither in cell cultures nor in a mouse model. Our results further indicate that AML cells possess multiple mechanisms to acquire #aspartate, underscoring the importance of this #metabolite!

The EAAT1 aspartate/glutamate transporter is dispensable for acute myeloid leukemia cell growth and response to therapy Acute myeloid leukemia (AML) is an aggressive malignancy of hematopoietic stem and progenitor cells characterized by profound metabolic dysregulation. Pyrimidine biosynthesis has emerged as a critical...

New paper from the lab! Acute myeloid #leukemia (AML) cells depend on nucleotide synthesis but blocking this pathway in patients comes with severe toxicity. We wondered if AML cells use EAAT transporters to take up aspartate, a key nutrient for nucleotide synthesis…
journals.plos.org/plosone/arti...

Congratulations to yesterday's winner - Célia Sergi from de Duve Institute, UCLouvain! The #ISEH2025 🏯 Race to Register continues with today's prize: A free 2026 ISEH membership! Register by 11:59pm US CT to be entered to win! www.iseh.org/2025Registration

Register for the 16 April Mini Symposium! Free for ISEH members and $30 for non-members.

🚨 Abstracts close 28 February. Submit your work for a chance to earn a symposium short talk, travel grant and Annual Meeting speaking slot.

iseh.org/Webinars-Eve...

Submit an abstract by 2 April for opportunities to present your work at #ISEH2026 🏙️! With over 45 short talk slots, don't miss this opportunity to share your findings with the international scientific community. Learn more: iseh.org/Annual-Meeti...

This week, we're finishing off our #SimplyBlood 🩸 interview series with the Experimental Hematology Editor-in-Chief Toshio Suda (IHCAMS, China) to share what's ahead for the ISEH official scientific journal. Watch the interview to learn insights on iseh.org/Publications....

Abstract submission just opened for #ISEH2026 in Frankfurt. Outstanding scientific program; welcoming community; and more than double the number of short talk slots for abstract to be presented in. Looking forward to seeing you there. @isehsociety.bsky.social

Abstract submission is now OPEN!!!
Students & Postdocs don’t miss this chance 👇🏻 @isehsociety.bsky.social is waiting for you 🎙️

Submit an abstract for the 2026 Mini Symposium by 28 February! Abstract submitters will have a chance to earn a symposium short talk, travel grant and #ISEH2026 🏙️ speaking slot.

👉️ iseh.org/Webinars-Eve...

Nominate yourself or a colleague for our prestigious ISEH Society Leadership Awards, including the new Lifetime Service Award. Nominations are accepted through 26 February. Learn more and submit a nomination ➡️ iseh.org/About/Awards...