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Francesca Magnani

@fmagnani

https://www.fmagnani-lab.com/

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06.12.2023
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Latest posts by Francesca Magnani @fmagnani

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Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a...

Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...

06.01.2026 15:39 ๐Ÿ‘ 46 ๐Ÿ” 21 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 2
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Pitfalls in the Modeling of Maltoside Detergents in Protein Structures This publication is Open Access under the license indicated. Learn More

๐ŸšจExcellent editorial in ACS Central Sci ๐Ÿ“ฃ

Thank you @carolynbertozzi.bskyverified.social for your support and to @louisflwilson.bsky.social for spotting these mistakes + drafting an excellent manuscript

#CryoEM #StructuralBiology
#vidalized

ACS Central Science pubs.acs.org/doi/full/10....

05.01.2026 13:40 ๐Ÿ‘ 17 ๐Ÿ” 8 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1
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Careers - Calico

Calico is hiring for roles in medicinal chemistry, process chemistry, preclinical magnetic resonance imaging, antibody engineering, toxicology #chemjobs
www.calicolabs.com/careers/

25.12.2025 03:33 ๐Ÿ‘ 11 ๐Ÿ” 6 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Station 2  | SOI Divestream 863
Station 2 | SOI Divestream 863 YouTube video by Schmidt Ocean

Livestream dive two. We see a strawberry squid and a sea of brittle stars: www.youtube.com/watch?v=HZLe...

15.11.2025 10:01 ๐Ÿ‘ 21 ๐Ÿ” 5 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Fantastic tool, thank you! I submitted to q.e.d. a grant proposal, and, notwithstanding the impressive insights and display of knowledge, itโ€™s clear the system still cannot grasp the different requirements between articles and project proposals. It would be extremely useful to add this capability.

17.10.2025 10:19 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

13.09.2025 00:04 ๐Ÿ‘ 266 ๐Ÿ” 82 ๐Ÿ’ฌ 20 ๐Ÿ“Œ 14
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๐Ÿšจ We have an open #postdoc position to join my new group at the University of Milan๐Ÿ‡ฎ๐Ÿ‡น to pioneer innovative #antiviral strategies using novel protein degradation technologies๐Ÿงฌ๐Ÿฆ 
๐Ÿ”— Details below
๐Ÿ”ฌ If you are a molecular biologist interested in viruses and new technologies, get in touch!! โœ‰๏ธ
#hiring #TPD

10.09.2025 13:54 ๐Ÿ‘ 3 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

RFK Jr. is upset that a recent large Danish study in Annals of Internal Medicine, conducted over 20 yrs in 1 M kids, found no association between aluminum in childhood vaccines & 50 different health conditions.

His request for the retraction was rejected.
๐Ÿงช www.reuters.com/business/hea...

11.08.2025 19:20 ๐Ÿ‘ 822 ๐Ÿ” 368 ๐Ÿ’ฌ 32 ๐Ÿ“Œ 55
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Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).

14.07.2025 12:09 ๐Ÿ‘ 27 ๐Ÿ” 33 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 4

And of course, it was fantastic as always to listen to Richard Henderson and Nigel Unwin

08.07.2025 23:15 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Awesome lineup for the โ€œStructure of Bacteriorhodopsin: 50 Years Onโ€ symposium @mrclmb.bsky.social : Niko Grigorieff, John Rubinstein, Gebhard Schertler, Bridget Carragher, and many more.

08.07.2025 23:10 ๐Ÿ‘ 6 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1

I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.

Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design

Please repost for reach ๐Ÿ’š

02.05.2025 14:39 ๐Ÿ‘ 162 ๐Ÿ” 279 ๐Ÿ’ฌ 7 ๐Ÿ“Œ 4
Multiscale guidance of AlphaFold3 with heterogeneous cryo-EM data

Really cool work on diffusing structures into cryo-EM densities by Ellen Zhong et. al arxiv.org/html/2506.04...

#cryoem

07.06.2025 17:52 ๐Ÿ‘ 8 ๐Ÿ” 6 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Human Technopole - Electron Microscopy (EM) Specialist APPLICATION CLOSING DATE: July 9th 2025About the InstituteHuman Technopole (HT) is an interdisciplinary life science research institute, created and supported by the Italian government, with the aim o

๐Ÿšจ We're Hiring! We're looking for a passionate and skilled EM Specialist to join our team! ๐Ÿ“… Application Deadline: July 9th, 2025 ๐Ÿ”— Learn more and apply here: careers.humantechnopole.it/o/electron-m...

12.06.2025 09:39 ๐Ÿ‘ 1 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Good suggestion! Keep them coming!!

10.06.2025 22:37 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Call me old fashioned (please donโ€™t ๐Ÿ˜Š) but I still value good textbooks particularly for teaching at entry level. A good amount of integration is almost always needed on a yearly basis anyway.

10.06.2025 22:35 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Hey, Iโ€™m looking for a bachelor level textbook on Synthetic Biology (ok for students with basic molecular biology knowledge): any suggestions please?? Perhaps @atinygreencell.bsky.social ?

10.06.2025 20:28 ๐Ÿ‘ 2 ๐Ÿ” 4 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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A Florida weatherman telling his viewers he can no longer be confident in his forecasts due to cuts to atmospheric science is the kind of resistance content Iโ€™m here for.

Kudos, Sir.๐ŸŒฆ๏ธ

03.06.2025 22:00 ๐Ÿ‘ 13273 ๐Ÿ” 4804 ๐Ÿ’ฌ 471 ๐Ÿ“Œ 416
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Finisce nel modo piรน inglorioso uno dei piรน grandi fallimenti politici ed economici della Repubblica.
I centri per migranti in Albania, costati 933 milioni di โ‚ฌ, a detta del Premier Rama, non possono funzionare.
Ecco cosa succede quando governi a colpi di slogan e propaganda.

30.05.2025 19:24 ๐Ÿ‘ 101 ๐Ÿ” 38 ๐Ÿ’ฌ 16 ๐Ÿ“Œ 6
Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company
Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company YouTube video by Amanpour and Company

David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors ๐Ÿ‘

youtu.be/8YhJM6zxYDw?...

24.05.2025 01:13 ๐Ÿ‘ 240 ๐Ÿ” 102 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1

Molto ben scritto! Diffondete anche e soprattutto fuori di questa bolla.

15.05.2025 16:02 ๐Ÿ‘ 3 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Thank you Guido for a great seminar #UniPV #DBB_unipv ! I am glad that your are gonna be in the neighbourhood๐Ÿ˜Š

08.05.2025 22:32 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Friends, if anyone is looking for an electron microscopist outside of the US, I'm listening. Open to any country, regardless of weather. Can do cryo, room temp, image anything from tissues to nanoparticles, viruses, catalysts, etc. Thanks for any lead(s).

02.05.2025 01:17 ๐Ÿ‘ 32 ๐Ÿ” 16 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 0
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New images could change cancer diagnostics, but ICE detained the Harvard scientist who analyzes them Without scientist Kseniia Petrovaโ€™s expertise, no one can fully unlock the dataโ€™s potential, putting crucial advancements in early cancer detection at risk.

Almost every line of this story would have been simply unbelievable a few months ago:

โ€”Pioneering cancer researcher;
โ€”*Arrested* at airport in Boston;
โ€”Now indefinite ICE detention in Louisiana;
โ€”"Crime": not declaring some frog-embryo samples for research.

Read it.
www.nbcnews.com/news/us-news...

22.04.2025 01:32 ๐Ÿ‘ 29236 ๐Ÿ” 13599 ๐Ÿ’ฌ 732 ๐Ÿ“Œ 848

I wished Columbia had done the right thing, too.

15.04.2025 01:41 ๐Ÿ‘ 9 ๐Ÿ” 2 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Highly recommended PhD opportunity!

14.04.2025 17:19 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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German research institute launches program to match threatened NIH grants with pharma funders As scientists across the U.S. face increasing uncertainty due to funding freezes and mass layoffs at health agencies, German research institute BioMed X is stepping in to offer a lifeline. | As scient...

'(...) German research institute BioMed X is stepping in to offer a lifeline. The institute has opened a matchmaking program to align threatened NIH grants with potential new funders from the pharmaceutical industry.'
www.fiercebiotech.com/research/ger...

12.04.2025 12:33 ๐Ÿ‘ 117 ๐Ÿ” 58 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 3