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Andre Gomes

@aspg

theoretical chemistry. molecular physics. and (mostly) some other stuff.

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Latest posts by Andre Gomes @aspg

C'est marrant comment les gens qui hurlent que le passé et les actions de Quentin ne justifient pas qu'il ait été tué sont les mêmes qui hurlaient que le passé et les actions de Nahel justifiaient qu'il ait été tué.
Ça doit être quantique.

14.03.2026 11:51 👍 560 🔁 166 💬 21 📌 2

The Ethical Use of Radium

Asbestos in the Classroom: A
Guide For Teachers

14.03.2026 11:45 👍 245 🔁 77 💬 3 📌 3
Screenshot of a Tweet by @TheChiefNerd inclusing an interview with Sam Altman.

The text in the Tweet says:
SAM ALTMAN: “We see a future where intelligence is a utility, like electricity or water, and people buy it from us on a meter.”

Screenshot of a Tweet by @TheChiefNerd inclusing an interview with Sam Altman. The text in the Tweet says: SAM ALTMAN: “We see a future where intelligence is a utility, like electricity or water, and people buy it from us on a meter.”

The whole "AI" industry is just based on the hope that they can deskill people fast enough that they'll have to rent back cognitive support systems. Forever.

It's like Uber. Just that they don't try to break existing transportation infrastructures but your brain.

12.03.2026 21:08 👍 5830 🔁 2336 💬 108 📌 241
Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies SARS-CoV-2 persistence is a proposed driver of Long COVID (LC), but the in-situ relationship between residual viral antigen and immune dysregulation remains poorly defined. To address this critical gap, we employed a high-resolution, multi-modal approach—combining RNAscope, GeoMx Digital Spatial Profiling (DSP), spatial transcriptomics, and multiplex immunofluorescence—on 25 terminal ileum and left colon biopsies from a clinical cohort of 8 LC participants and 5 healthy controls. We confirmed the persistence of SARS-CoV-2 Spike transcript and protein in the gut tissue of all LC cases and controls tested. Yet, comparison of Spike-positive (Spike+) regions in LC versus healthy control colon tissues revealed a differential, symptomatic state-associated signature, with 57 differentially expressed genes (DEGs) (26 upregulated, 31 downregulated), revealing genes that disrupt the immune response in LC subjects. LC colon Spike+ regions demonstrated increased expression of AQP8 and other absorptive-related genes (SLC26A3, SLC26A2, and CLCA4) which are involved with Crohn′s disease along with transcripts involved in tumorigenesis (GUCA2A, S100P, TSPAN1). Simultaneous downregulation of key homeostatic chemokines (CXCL13, CCL19, CCL21), and other transcripts reported to exhibit low expression in colorectal cancers (TMEM88B, NIBAN3, DMBT1), suggesting a paradox of epithelial tissue stress yet dysfunctional immune trafficking. Further analysis comparing Spike+ versus Spike- regions within LC colon tissue demonstrated an active, localized, antigen-driven immune microenvironment, identifying 122 DEGs (82 upregulated, 40 downregulated), including tumorigenesis genes. Cellular deconvolution of Spike+ regions revealed a statistically significant focal enrichment of myeloid-derived cells (macrophages, non-classical/intermediate monocytes), plasma cells, and regulatory T cells, coupled with significant enrichment in T-cell-related pathways, including ″Antigen processing and presentation,″ and ″Th1/Th2/Th17 cell differentiation″. The ileum displayed a similar, though less pronounced, signature, demonstrating these statistically significant findings are specific to the colon of LC subjects. In contrast, corresponding Spike+ vs. Spike- analysis in healthy control colon tissues showed a more modest transcriptional response with 38 DEGs. Our data provide robust evidence that persistent SARS-CoV-2 Spike protein detection in the gut is not immunologically inert. Instead, it is actively associated with distinct, immune cell composition shifts and a dysfunctional pro-inflammatory transcriptional profile, supporting the hypothesis that retained viral antigen drives chronic immune dysregulation in tissue of Long COVID subjects. ### Competing Interest Statement The authors have declared no competing interest.

Proud to have worked with the brilliant @drmfreire on this new study looking into spike protein in #LongCOVID. The most important part of this study that doesn't just look for spike protein in folks with LC and healthy controls, but it also uses a technique called
www.biorxiv.org/content/10.6...

1/

14.03.2026 02:42 👍 96 🔁 24 💬 3 📌 2

It’s Long Covid Awareness Day (which I think should be the Ides of March, for reasons that will become clear.)

Some of you have heard this before. But I wanted to share my Long Covid story, because I think you should hear it.

On my birthday in November 2022, I woke up with Covid.

14.03.2026 01:27 👍 759 🔁 289 💬 14 📌 37

I’ve never used any of the LLM chatbots, avoided them even in the early days, because they had all the hallmarks of a major cognitive and psychological hazard from the very beginning

“I’m not gonna use this shit unless I can be sure it won’t mess me or others up” is an entirely reasonable position

13.03.2026 10:36 👍 50 🔁 7 💬 4 📌 1
Preview
I Watched 6 Hours of DOGE Bro Testimony. Here's What They Had to Say For Themselves The hours of videos provide fascinating, or perhaps horrifying, insight into the thinking of someone inside DOGE.

I have watched 6 hours of a DOGE bro deposition. The whole thing, start to finish. It's a fascinating, and horrifying, look at the people who caused so much damage, didn't really achieve anything at all, while still being so sure they are right. Here's what they said: www.404media.co/i-watched-6-...

12.03.2026 17:28 👍 5729 🔁 2085 💬 192 📌 140
a snippet of a mini-comic, at top - straight line stretches from point A to B. Immediately below, same dot at A, then becomes a curving, meandering line that winds through the page and ends at a point with rays and a question mark emanating from it. Text reads: "Nothing can do this for you - for that robs you of experience and conflates answers with learning. Rather, it's all the decisions you make along the way, the mistakes, struggles, and surprises! These pathways you create - this is learning. 

https://spinweaveandcut.com/fall-2025-syllabi/

a snippet of a mini-comic, at top - straight line stretches from point A to B. Immediately below, same dot at A, then becomes a curving, meandering line that winds through the page and ends at a point with rays and a question mark emanating from it. Text reads: "Nothing can do this for you - for that robs you of experience and conflates answers with learning. Rather, it's all the decisions you make along the way, the mistakes, struggles, and surprises! These pathways you create - this is learning. https://spinweaveandcut.com/fall-2025-syllabi/

In case anyone needs it for their syllabi, my statement in gen-Ai from the minicomic I made as a syllabus for class last semester. All online and printable here spinweaveandcut.com/fall-2025-sy...

06.01.2026 16:54 👍 516 🔁 222 💬 10 📌 16
Preview
La Chine, nouvelle superpuissance scientifique Le pays ambitionne d’être au premier plan dans toutes les disciplines scientifiques, en particulier l’astronomie, avec le télescope FAST, symbole de ce changement d’échelle. Si ses institutions et ses...

Si le système scientifique et universitaire français s'effondre, ce n'est pas seulement parce que la Chine et l'Inde montent en puissance.

Il s'effondre SPECIFIQUEMENT du fait des politiques désastreuses menées depuis 2004: la doctrine Aghion.
www.lemonde.fr/sciences/art...

11.03.2026 08:35 👍 38 🔁 30 💬 1 📌 3
Preview
Elon Musk's xAI wins permit to build power plant in Mississippi despite pollution concerns Mississippi regulators authorized xAI to build a power plant with 41 natural gas-burning turbines in Southaven to power its nearby data centers.

You'd be hard pressed to find a worse climate villain when it comes to data centres than Elon Musk.

www.cnbc.com/2026/03/10/e...

By my own calculations, Musk's carbon bomb slop factories are undoing nearly half to all of the emissions cuts from Tesla products ketanjoshi.co/2026/03/02/m...

11.03.2026 20:00 👍 169 🔁 72 💬 7 📌 3

March is Long Covid awareness month, and one thing you should probably be aware of is no matter how back to normal you are, you are at risk of complications from Covid, including LC. And those excess death numbers aren’t great either.

11.03.2026 20:02 👍 102 🔁 60 💬 4 📌 2

To be exquisitely clear, I never volunteered for this, I was never asked about this, and I do not consent to this.

Pretty sure everyone I know on the list (much longer than what is shown) would say the same.

Grammarly can fuck off to the edge of the universe and keep fucking off beyond that.

11.03.2026 20:10 👍 74 🔁 20 💬 5 📌 0

Both of the options here are human writers. The first option is unprocessed human writing and the second option is human writing run through a language model to reproduce the same outputs with different words

If it couldn't have existed without training data, it isn't creating anything at all.

10.03.2026 11:30 👍 597 🔁 142 💬 21 📌 23

modern life gets a lot simpler once you learn to remember this

09.03.2026 16:02 👍 381 🔁 40 💬 3 📌 0

i think this is an important point - not just the way ai coding tools can affect an individual programmer, but the way it interrupts a social practice / a community of people making software

07.03.2026 04:32 👍 128 🔁 28 💬 5 📌 2
Preview
Hey ChatGPT, write me a fictional paper: these LLMs are willing to commit academic fraud Mainstream chatbots presented varying levels of resistance to deliberate requests for fabrication, study finds.

Why tenured academics and administrators insist that using this technology is unproblematic and just how the future should work with none of our input is baffling to me. Feels like a modern cargo cult.

05.03.2026 11:54 👍 430 🔁 92 💬 5 📌 1

okay, Ill bite.
What do you think the point of reading for and writing a literature review is? The process of reading and writing is crucial for THINKING. Your ideas are shaped by all of this, offloading it to gAI, no matter how "good" you think gAI is at it defeats the purpose entirely.

03.03.2026 19:01 👍 1375 🔁 289 💬 53 📌 32
Preview
Are AI-generated summaries suitable for studying and research? Despite didactic, ethical, and environmental concerns, the use of GenAI is on the rise in academia. For most applications, the jury is still out on whether and how they will benefit education and rese...

This is one of the most reasoned & persuasive arguments for not allowing LLMs anywhere near reading & writing intensive classrooms. We can 100% choose not to outsource our reading & writing labor to a bot, and model for our students why they should do the same. #EduSky

www.tue.nl/en/our-unive...

28.02.2026 11:47 👍 87 🔁 40 💬 3 📌 4
Video thumbnail

Learning a second language can be hard. Signing up for Pre-K and 3-K is easy.

Go to myschools.nyc to apply today. Deadline is tomorrow at midnight!

26.02.2026 15:25 👍 14250 🔁 2137 💬 346 📌 445
Preview
Actually, the left is winning the AI debate But it does need to get organized.

The left is not "missing out" on AI. It's winning the argument. Americans worry about AI and dislike tech CEOs. They're mobilizing against data centers. They support regulation, even refusal.

Calls for the left to embrace AI are an effort to change the terms of the debate in Silicon Valley's favor.

26.02.2026 17:15 👍 961 🔁 317 💬 13 📌 27
Preview
Long Covid ruled as occupational disease in nurses - Switzerland Long Covid confirmed as an occupational disease in nurses.

Think what this decision means to you all. Schools are full of covid. Over 120k UK children have long Covid and they have no rights. We know #Covidisairborne and that means indoors anywhere where anyone has COVID! www.europesays.com/ch/17407/

26.02.2026 10:21 👍 53 🔁 32 💬 1 📌 2

For proper citation of DIRAC26, please consult www.diracprogram.org/doku.php?id=...

25.02.2026 15:37 👍 4 🔁 1 💬 0 📌 0
dirac-users - Google Groups

Users are encouraged to join the user's mailing list groups.google.com/group/dirac-...

25.02.2026 15:37 👍 3 🔁 1 💬 0 📌 0
DIRAC - EasyBuild - building software with ease

DIRAC26 can also be installed via EasyBuild, check out docs.easybuild.io/version-spec...

25.02.2026 15:37 👍 3 🔁 1 💬 0 📌 0
Preview
demo_notebooks · release-26 · dirac / dirac · GitLab DIRAC source code repository.

In addition to our updated documentation, with the DIRAC26 additional jupyter notebooks are available gitlab.com/dirac/dirac/...

25.02.2026 15:36 👍 3 🔁 1 💬 0 📌 0
start [DIRAC]

The DIRAC26 release of the open-source @diracprogram.bsky.social code for 2- and 4-component relativistic molecular electronic structure calculations is now out ! Please consult our website diracprogram.org

25.02.2026 15:36 👍 3 🔁 1 💬 0 📌 1

DIRAC26 introduces CASPT2, extended functionalities to the ExaCorr coupled cluster code and to the visualization module, new Dyall basis sets, and new one electron property operators. Check out diracprogram.org/doku.php?id=... for more details !

25.02.2026 15:36 👍 3 🔁 1 💬 0 📌 0
DIRAC26 Project website: https://diracprogram.org The DIRAC program computes molecular properties using relativistic quantum chemical methods. It is named after P.A.M. Dirac, the father of relativistic electr...

The DIRAC26 source code is available from ZENODO at zenodo.org/records/1866... !

25.02.2026 15:36 👍 3 🔁 1 💬 0 📌 0

Bonjour, c'est pour savoir à quel moment il aura le même traitement que l'assistant parlementaire du député LFI. Je demande juste comme ça moi, une histoire un peu bête de principes et de lois et tout ça, enfin voilà quoi...

25.02.2026 11:47 👍 15 🔁 8 💬 1 📌 2
Full report [1.7 MB]
Front, Preface, Acknowledgements [101.0 KB]
Chapter 1 - Introduction [94.9 KB]
Chapter 2 - Fisheries: taking stock [155.6 KB]
Chapter 3 - Radiation: early warnings; late effects [89.9 KB]
Chapter 4 - Benzene: an historical perspective on the American and European occupational setting [155.6 KB]
Chapter 5 - Asbestos: from 'magic' to malevolent mineral [141.1 KB]
Chapter 6 - PCBs and the precautionary principle [176.5 KB]
Chapter 7 - Halocarbons, the ozone layer and the precautionary principle [147.4 KB]
Chapter 8 - The DES story: long-term consequences of prenatal exposure [119.6 KB]
Chapter 9 - Antimicrobials as growth promoters: resistance to common sense [103.5 KB]
Chapter 10 - Sulphur dioxide: from protection of human lungs to remote lake restoration [104.6 KB]
Chapter 11 - MTBE in petrol as a substitute for lead [176.9 KB]
Chapter 12 - The precautionary principle and early warnings of chemical contamination of the Great Lakes [112.7 KB]
Chapter 13 - Tributyltin (TBT) antifoulants: a tale of ships, snails and imposex [154.8 KB]
Chapter 14 - Hormones as growth promoters: the precautionary principle or a political risk assessment? [99.1 KB]
Chapter 15 - ‘Mad cow disease’ 1980s–2000: how reassurances undermined precaution [138.7 KB]
Chapter 16 - Twelve late lessons [246.2 KB]
Chapter 17 - Conclusions [161.4 KB]
Some summary points [59.3 KB]

Full report [1.7 MB] Front, Preface, Acknowledgements [101.0 KB] Chapter 1 - Introduction [94.9 KB] Chapter 2 - Fisheries: taking stock [155.6 KB] Chapter 3 - Radiation: early warnings; late effects [89.9 KB] Chapter 4 - Benzene: an historical perspective on the American and European occupational setting [155.6 KB] Chapter 5 - Asbestos: from 'magic' to malevolent mineral [141.1 KB] Chapter 6 - PCBs and the precautionary principle [176.5 KB] Chapter 7 - Halocarbons, the ozone layer and the precautionary principle [147.4 KB] Chapter 8 - The DES story: long-term consequences of prenatal exposure [119.6 KB] Chapter 9 - Antimicrobials as growth promoters: resistance to common sense [103.5 KB] Chapter 10 - Sulphur dioxide: from protection of human lungs to remote lake restoration [104.6 KB] Chapter 11 - MTBE in petrol as a substitute for lead [176.9 KB] Chapter 12 - The precautionary principle and early warnings of chemical contamination of the Great Lakes [112.7 KB] Chapter 13 - Tributyltin (TBT) antifoulants: a tale of ships, snails and imposex [154.8 KB] Chapter 14 - Hormones as growth promoters: the precautionary principle or a political risk assessment? [99.1 KB] Chapter 15 - ‘Mad cow disease’ 1980s–2000: how reassurances undermined precaution [138.7 KB] Chapter 16 - Twelve late lessons [246.2 KB] Chapter 17 - Conclusions [161.4 KB] Some summary points [59.3 KB]

useful on this point with case studies:

"Late lessons from early warnings: the precautionary principle 1896-2000"
www.eea.europa.eu/en/analysis/...

28.01.2026 07:28 👍 58 🔁 14 💬 2 📌 7