Christos Kallis

FDA Approves Genentech’s Gazyva for the Treatment of Lupus Nephritis SOUTH SAN FRANCISCO, Calif., October 20, 2025--Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), announced today that the U.S. Food and Drug Administration (FDA) has approved Gazyva...

Obinituzumab aka ‘Obi’ is now FDA approved for lupus nephritis

finance.yahoo.com/news/fda-app...

#lupus

KDIGO 2025 Clinical Practice Guideline for the Management of Immunoglobulin A Nephropathy (IgAN) and Immunoglobulin A Vasculitis (IgAV) This article is published as part of a supplement sponsored by Kidney Disease: Improving Global Outcomes (KDIGO). The opinions or views expressed in this supplement are those of the authors and do not...

The @kdigo.org IgA guidelines published www.kidney-international.org/article/S008...

We discussed them with Jon Barratt here: youtu.be/OChs5BcTEGE?... on #NephGR

Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension | NEJM Aldosterone dysregulation plays an important pathogenic role in hard-to-control hypertension. In several studies, baxdrostat, an aldosterone synthase inhibitor, reduced the seated systolic blood pr...

The era of ASIs is slowly dawning

www.nejm.org/doi/full/10....

(Yeah spironolactone is just as good and cheaper)

Disclosure: we recruited patients for this one

Morphologically Normal-Appearing Adrenal Glands as a Prevalent Source of Aldosterone Production in Primary Aldosteronism AbstractBackground. Normal-appearing adrenal glands on cross-sectional imaging may still be the source of aldosterone production in primary aldosteronism (

#WeekendReads from #EditorsChoice

Can you have normal looking adrenal glands with primary aldosteronism?

🔗 academic.oup.com/ajh/article/... 🔓

Congratulations!! Much deserved.

High or Low Phosphate? Are we Missing the (P)oint? — NephJC This week, we will discuss the phosphate targets in dialysis. Are you aiming for HIgh or Low?

HiLo, HiLo it's off to work we go! ⛏️
Join us 9 pm EST 8/5/25 to discuss. #NephJC #NephSky
Controlling Phos in patients on HD is a lot of work, but is it worth it? HiLo looks at hospitalization & death in low/high Phos goals. Will we finally have a RCT with answers ⁉️
www.nephjc.com/news/hilo-tr...

The HiLo Trial - Visual Abstract — NephJC Is a lower versus higher phosphate target beneficial to patients undergoing hemodialysis? Check out this crisp VA by Dr Sejal Lakhani

😎Check out the VA for HiLO by @sejalplakhani.bsky.social
🆒 This should be quite the discussion, don't miss it!
#NephJC #NephSky
www.nephjc.com/news/2025/8/4/the-hilo-trial-visual-abstract

FDA Approves Pegcetacoplan for C3G and IC-MPGN | Docwire News The FDA approved pegcetacoplan for treating C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN in patients age 12 and older.

⚠️ The FDA has approved pegcetacoplan (Empaveli) for treating C3G and IC-MPGN. #kidneydisease #nephrology #nephsky #c3g www.docwirenews.com/post/fda-app...

just learned this & mind blown 🤯

CKD-EPI, MDRD etc give us GFR corrected for body surface area (ml/min/1.73m2)

BUT we're supposed to use the *absolute* GFR (ml/min) for drug dosing (eg KDIGO 2024 guidelines below; FDA agrees)

in obesity, the computer's ml/min/1.73m2 can be way too low #EMIMCC

Fascinating CKD data from ACC today. Some highlights from the data:

1.) Tirzepatide led to an *improvement* in eGFR at 52 weeks in all patients (by cystatin C), but only in patients with CKD (by eGFR-creatinine)

#NephSky
@hswapnil.medsky.social @kidneyboy.bsky.social
@nephjc.bsky.social

#APICAT trial at #ACC25 #LBCT #cardioonc

🩸apixaban low 2.5 mg vs full dose 5mg in patients with cancer+VTE: primary endpoint recurrent VTE
🩸more than half female! 👏🏽👏🏽
🩸the low dose was significant for noninferiority for efficacy & ⤵️ bleed
🩸no increase in deaths

💥 ADPKD = 6.9x ↑ risk of intracranial aneurysms (ICA)
🧠 KDIGO recommends ICA screening if:
📌 Personal hx of SAH
📌 Family hx of ICA, SAH, or unexplained sudden death
(1D) #NephJC

#COL4A5-p.Gly624Asp is the Predominant #Variant in Europe Associated With a Mild #Alport Syndrome Phenotype

#VisualAbstract by @thana_susan

www.kireports.org/ar...

Roger's cheat sheet that converts Hydrogen concentration to pH

The classic ABG "map"

[H+] = 24 x pCO2/[HCO3-]

The Channelers in their bowling shirts

Channel Your Enthusiasm, Chapter 17 of Burton Rose Clinical Physiology of Acid-Base and Electrolyte Disorders is out!

An hour and a half of "Introduction to Simple and Mixed Acid-Base Disorders!"

www.rosebook.club/episodes/202...

🆕 #Obinutuzumab (Obi) in Lupus Nephritis: the REGENCY Trial

Phase 3 RCT: Obi vs PBO
🫘 Pts w/ SLE nephritis Class III/IV ± 5
🎲 Randomized 1:1 to OBI v PBO (+MMF/steroids)
📊 Obi: ⇡rate of renal response and improved renal outcomes

#LupusNephritis #RheumSky #NephSky #MedSky #Lupus

Undercover Aldosterone — NephJC This week, we will discuss the origins of primary hyperaldosteronism in normotensive patients. Could this undetected anomaly be the cause of idiopathic hypertension and CKD?

I learned a lot about subclinical primary aldosteronism reading this piece from the unsinkable @brianrifkin.bsky.social 👇

www.nephjc.com/news/primary...

FDA greenlights first clinical trials for genetically modified pig kidney transplants in humans Two companies have received FDA approval to conduct clinical trials transplanting genetically modified pig kidneys into patients with kidney failure

Omg omg omg

www.kidneyfund.org/article/fda-...