Thelonevirologist

Defining the transmissible dose 50% for two pandemic influenza viruses in ferrets | Journal of Virology Ferrets are the gold standard animal model used to assess the transmissibility of influenza viruses. Airborne transmission is evaluated by infecting donor ferrets with a high virus dose and monitoring...

Defining the transmissible dose 50% for two pandemic influenza viruses in ferrets journals.asm.org/doi/10.1128/...

Knockout of key receptors (PDGFRA and NRP2) in the guinea pig model blocks direct and endocytic pathways of CMV cell entry The guinea pig with guinea pig cytomegalovirus (GPCMV) is the only small-animal model for congenital cytomegalovirus, a leading cause of cognitive impairment and hearing loss in newborns. GPCMV encode...

Knockout of key receptors (PDGFRA and NRP2) in the guinea pig model blocks direct and endocytic pathways of CMV cell entry

www.microbiologyresearch.org/content/jour...

Evaluating how infectious bursal disease virus (IBDV) infection influences influenza H3N8 challenge in chickens Infectious bursal disease virus (IBDV) causes an endemic immunosuppressive disease in chickens. Prior exposure to IBDV influences the pathogenesis and shedding of chicken strains of influenza A virus ...

Evaluating how infectious bursal disease virus (IBDV) infection influences influenza H3N8 challenge in chickens

www.microbiologyresearch.org/content/jour...

Effectiveness, Comparative Effectiveness, and Harms of COVID-19 Vaccines in Adults Who Are Not Pregnant or Immunocompromised: A Rapid Review for the American College of Physicians | Annals of Internal... Background: The SARS-CoV-2 Omicron variant continues to pose a global health burden. Purpose: To assess the effectiveness, comparative effectiveness, and harms of COVID-19 vaccines in nonpregnant, non...

Effectiveness, Comparative Effectiveness, and Harms of COVID-19 Vaccines in Adults Who Are Not Pregnant or Immunocompromised: A Rapid Review for the American College of Physicians

www.acpjournals.org/doi/10.7326/...

Omicron-adapted COVID vaccines may reduce death, hospitalization risk

Omicron-adapted COVID vaccines may reduce death, hospitalization risk www.cidrap.umn.edu/covid-19/omi...

Quick takes: Hemorrhagic fever in DR Congo, testing option for TB, CDC acting director countdown Federal law states that acting directors at the CDC have 210 days to serve, after which the administration should name a nominee for the position.

Quick takes: Hemorrhagic fever in DR Congo, testing option for TB, CDC acting director countdown www.cidrap.umn.edu/ebola/quick-...

Recent pandemic viruses, including SAR-CoV-2, spread directly to people without adaptation, researchers say

Recent pandemic viruses, including SAR-CoV-2, spread directly to people without adaptation, researchers say www.cidrap.umn.edu/covid-19/rec...

Stage-specific regulation of KSHV infection by HIF-1α | Journal of Virology The current view is that the default pathway of KSHV infection is the establishment of latency, however, how this is altered under physiological stress conditions remains largely unknown. We previously showed that hypoxia, or the expression of its transcription factor HIF-1α alone, promotes the establishment of lytic rather than latent KSHV infection. In this study, we show that the duration of hypoxia, as well as the timing and duration of HIF-1α expression, are crucial determinants in facilitating lytic de novo KSHV infection. Notably, we found that PRC2-mediated heterochromatin inhibits the HIF-1α-mediated upregulation of lytic genes as chromatinization of the KSHV genome progresses during infection. Our findings offer a deeper understanding of how epigenetic regulation intersects with host stress responses to influence viral pathogenesis.

Stage-specific regulation of KSHV infection by HIF-1α journals.asm.org/doi/10.1128/...

Repression of EEF1D by KSHV RTA promotes viral lytic reactivation | Journal of Virology Kaposi's sarcoma-associated herpesvirus (KSHV) establishes lifelong latency in host cells but can periodically reactivate, a process that is essential for viral spread and disease development. The vir...

Repression of EEF1D by KSHV RTA promotes viral lytic reactivation journals.asm.org/doi/10.1128/...

Porcine reproductive and respiratory syndrome virus exploits ESCRT-II subunit EAP20 for entry and replication | Journal of Virology PRRSV remains one of the most economically significant pathogens in the global swine industry. Current control strategies are largely hindered because PRRSV pathogenesis has not been fully elucidated. In this study, we identified EAP20, a core subunit of ESCRT-II, as a multifaceted proviral factor that participated in PRRSV entry and replication. These findings provide new insights into the interplay between PRRSV and the host ESCRT machinery, laying a foundation for the development of more effective strategies for PRRS control.

Porcine reproductive and respiratory syndrome virus exploits ESCRT-II subunit EAP20 for entry and replication journals.asm.org/doi/10.1128/...

Vaccine-Elicited Antibody Responses to Influenza A (H3N2) Subclade K This cohort study examines antibody responses to influenza A(H3N2) subclade K and other strains before and after vaccination against influenza.

Vaccine-Elicited Antibody Responses to Influenza A(H3N2) Subclade K

jamanetwork.com/journals/jam...

Colorado, North Dakota see uptick in measles activity In Utah, health officials are warning that measles patients are suffering from anemia and liver inflammation.

Colorado, North Dakota see uptick in measles activity www.cidrap.umn.edu/measles/colo...

Will animal reservoirs give us the next SARS-CoV-2 variant?

Will animal reservoirs give us the next SARS-CoV-2 variant?

journals.plos.org/plospathogen...

Mosquito-borne viruses, vaccine-borne hope From chikungunya and dengue to yellow fever and Zika, mosquito‑transmitted diseases are spreading with urbanization, travel and climate change. A new generation of vaccines, trials and public‑health t...

Mosquito-borne viruses, vaccine-borne hope www.nature.com/articles/d41...

Quick takes: Polio in 2 nations, Sudan’s cholera outbreak ends, avian flu vaccine trials in UK Sudan's 18-month cholera outbreak resulted in more than 100,000 cases nationwide, with an estimated 2,408 deaths.

Quick takes: Polio in 2 nations, Sudan’s cholera outbreak ends, avian flu vaccine trials in UK www.cidrap.umn.edu/cholera/quic...

Babies with COVID-19 develop more serious disease than those with RSV, US data reveal

Babies with COVID-19 develop more serious disease than those with RSV, US data reveal www.cidrap.umn.edu/covid-19/bab...

US measles total approaches 1,300 infections The CDC notes that Texas has now recorded 93 cases this year after having the nation's largest outbreak last year.

US measles total approaches 1,300 infections www.cidrap.umn.edu/measles/us-m...

A cross-sectional serological study of bats in the United States Virgin Islands during 2019 to 2020 reveals no evidence of rabies virus exposure

www.nature.com/articles/s41...

North American Culex pipiens mosquitoes are competent for Usutu virus transmission - npj Viruses npj Viruses - North American Culex pipiens mosquitoes are competent for Usutu virus transmission

North American Culex pipiens mosquitoes are competent for Usutu virus transmission
www.nature.com/articles/s44...

Immunogenicity of SARS-CoV-2 vaccine prototype based on virus-like particles of hepatitis B core antigen from genotype G and interleukin 12 expressing Semliki Forest virus as a genetic adjuvant Virus-like particles (VLPs) based on hepatitis B core antigen (HBc) represent an immunogenic and modular platform for epitope presentation. In this study, the VLPs formed by the modified recombinant h...

Immunogenicity of SARS-CoV-2 vaccine prototype based on virus-like particles of hepatitis B core antigen from genotype G and interleukin 12 expressing Semliki Forest virus as a genetic adjuvant

www.microbiologyresearch.org/content/jour...

Panzootic H5 influenza viruses acquired resistance to human head interface antibodies Antibodies to the influenza hemagglutinin protein (HA) confer the strongest protection against infection. Immunity elicited by endemic, seasonal, human viruses is correlated with diminished disease se...

Panzootic H5 influenza viruses acquired resistance to human head interface antibodies

journals.plos.org/plospathogen...

Silent reservoir species are shaping the emergence of Usutu virus - Nature Ecology & Evolution By collating molecular, serological and population data from multiple wildlife surveillance schemes, this paper demonstrates that host species other than the most-affected and sentinel blackbird speci...

Silent reservoir species are shaping the emergence of Usutu virus

www.nature.com/articles/s41...

A stable subgenomic reporter coronavirus enables transcriptional profiling of bystander cell

www.biorxiv.org/content/10.6...

An innovative nasal nanovaccine against SARS-CoV-2 induces systemic and upper airway immunity controlling viral replication

www.nature.com/articles/s41...

A dual role for ER-Golgi cargo receptor LMAN1 in supporting CSFV replication and restraining RLR signaling | Journal of Virology Classical swine fever virus (CSFV) remains a major threat to global swine health, yet the host factors that the virus exploits to support virus infection and proliferation are not fully understood. He...

A dual role for ER-Golgi cargo receptor LMAN1 in supporting CSFV replication and restraining RLR signaling journals.asm.org/doi/10.1128/...

Experimental infection of carpet pythons (Morelia spilota) with sunshinevirus | Journal of Virology Australian pythons are extensively kept in captivity. Since the 1990s, native Australian snakes with neuro-respiratory signs of disease, sometimes fatal, had been presenting to veterinarians in Australia. Research conducted at Murdoch University on some of these snakes resulted in the discovery of a novel virus, now named sunshinevirus (Sunviridae). Widespread follow-up PCR testing of pythons throughout Australia linked sunshinevirus infection to both asymptomatic virus-carriers and pythons showing signs of disease. Experimental infections were conducted to determine whether sunshinevirus infection caused disease in Australian pythons. The experiments demonstrated a causal relationship by fulfilling Koch’s postulates, and 5/6 infected animals developed neurological disease. Infected pythons shed virus persistently for months, but control animals remained uninfected. Our findings provide veterinarians with valuable information for the management of sunshinevirus in zoos and private collections.

Experimental infection of carpet pythons (Morelia spilota) with sunshinevirus journals.asm.org/doi/10.1128/...

Animal organoids as transformative platforms for viral infections and zoonotic cross-species viral research | Journal of Virology As obligate intracellular parasites that rely on host cellular machinery for replication, viruses recall appropriate experimental models for elucidating virus-host interactions and pathogenic mechanisms. Traditionally, virology research has relied on two principal approaches: two-dimensional (2D) cell monolayers and in vivo animal models. Each methodology has contributed substantially to fundamental understanding of viral biology and pathogenesis, while presenting significant methodological constraints that would limit their translational relevance.

Animal organoids as transformative platforms for viral infections and zoonotic cross-species viral research journals.asm.org/doi/10.1128/...

Interaction of coronavirus E protein with BRD2 plays important regulatory roles in viral replication and induction of pro-inflammatory response | Journal of Virology Severe coronavirus infections usually result in excessive secretion of inflammatory cytokines and chemokines, leading to cell death and ultimately collapse of the immune system with fatal outcomes. So...

Interaction of coronavirus E protein with BRD2 plays important regulatory roles in viral replication and induction of pro-inflammatory response journals.asm.org/doi/10.1128/...

Parents Tried to Shield Their Children From Vaccines. Instead They Got Measles.

Parents Tried to Shield Their Children From Vaccines. Instead They Got Measles. www.nytimes.com/2026/03/03/u...

Public Health Alerts: Antibodies elicited by the 2025-2026 influenza vaccine

Public Health Alerts: Antibodies elicited by the 2025-2026 influenza vaccine www.cidrap.umn.edu/public-healt...