pH gradients are central to physiology, from vesicle acidification to the acidic tumor microenvironment. But how do we program proteins to respond to pH? In our new preprint biorxiv.org/content/10.110…, we developed computational methods to rationally design pH-sensitive binders. 🧵
ICYMI: DOGE signed an agreement with Louis DeJoy to slash 10,000 jobs from the already-understaffed USPS.
The USPS is the nation’s lifeline, ensuring delivery to every corner of the country.
We cannot allow it to be dismantled, sold off, and handed over to billionaires for profit.
ALA response to White House assault on IMLS To dismiss the mission of an agency that advances opportunity and learning is to dismiss the aspirations and everyday needs of millions of Americans. And those who will feel that loss most keenly live in rural communities. As seedbeds of literacy and innovation, our nation’s 125,000 public, school, academic and special libraries deserve more, not less support. Libraries translate 0.003% of the federal budget into programs and services used by more than 1.2 billion people every year. Show Up for Our Libraries, ALA American Library Association, #ForOurLibraries
President Trump's executive order to eliminate the Institute of Museum & Library Services would have disastrous effects for communities nationwide. We call on all Americans who value reading & learning to reach out to their elected leaders.
Read ALA's full response: www.ala.org/news/2025/03...
We are in a biotech space race, cutting off basic science via slashing NIH and NSF funding robs the US of our competitive advantage: early innovation.
NIH is the best investment there is.
www.forbes.com/sites/michae...
This is a super clear and helpful article explaining why the 15% indirect cost rate is unfair, hurts science, and does NOT increase $ for research:
www.science.org/doi/10.1126/...
‘With the current turmoil, China could surpass the U.S. in the near future,’ Nobel Prize winner David Baker warns
www.wsj.com/articles/bio...
J.P. Flores, a core organizer for today's rallies and a bioinformatics researcher at the University of North Carolina, Chapel Hill, told Nature: “March 7 is the beginning — I don’t necessarily see it as the endpoint.” #StandUpForScience www.nature.com/articles/d41...
Christine, 33, explains that young scientists will be hit hardest by these cuts.
"If you don't get grants and bring in money, you're not seen as a viable scientist, and so that's the career to becoming a professional and being able to stay in the field."
Currently, NIH's Center for Scientific Review reviews 66,000 grant applications a year, with panels run by NIH’s separate institutes reviewing the rest.
Under a new plan, the institute-run panels will be eliminated, and many of the scientists overseeing them will be laid off. scim.ag/3QP0FUG
#standupforscience #seattle
It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:
The cost-saving claims don’t hold up. Every dollar in NIH research grants generates $2.46 in economic activity, research shows—a total of $93 billion in 2023 alone.
“It’s incredible to me that we would give up this thing that has such obvious societal benefits,” says biologist Mark Peifer.
Republicans aren’t hiding anything. Their priorities are written in black and white: trillions of dollars in tax breaks to the rich, while making savage cuts to Medicaid, housing, nutrition and education. The reconciliation bill will make the rich even richer and the poor poorer.
For decades, the U.S. has funded science, then left scientists to direct their own work. Science has flourished, and the country has benefited. Now the government is testing just how much it can renegotiate that relationship, @katherinejwu.com writes:
Use this form to tell us how the new US administration is affecting your research, or suggest future coverage
https://go.nature.com/4aYn9Me
