Johanna Ivaska

Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties - Nature Materials Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.

What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity!

www.nature.com/articles/s41...

@mathildemathieu.bsky.social @ivaskalab.bsky.social New discovery from us! Leupaxin, a paxillin family member typically expressed in immune cells, negatively regulates durotaxis and mechanoresponsiveness in metastatic breast cancer cell variants and in cells cultured on soft ECM lnkd.in/diEk8DSR

I am very excited to share this preprint which has been my main postdoc project! We identified leupaxin as a negative regulator of durotaxis via paxillin-FAK inhibition in MDA-MB-231 brain and bone tropic metastatic variants. www.biorxiv.org/content/10.6...

I will be recruiting two postdocs early next year.
- One image analyst
- one biologist interested in working on lymphatics!

Reach out if you are interested 👍

There is a permanent positon open at our centre. Read more & apply 👉 ats.talentadore.com/apply/erikoi...

Laboratory Engineer (Senior), in Advanced Imaging, 1.5.2026-31.12.2028

🚨 Job Alert! 🚨

We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇

abo.rekrytointi.com/paikat/index...

#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social

Postdocs wanted - Please spread the word! We are looking for one bioinformatician and 1-2 cell biologists with different expertise! See the job ad below for more information and links to the job descriptions!

Please reach out if you are interested

Ivaska cell adhesion and cancer Lab Integrins, matrix, motility and mechanotransduction in cancer

Introductory post on 🦋! We're a research group headed by Prof. Johanna Ivaska interested in understanding how integrins contribute to every step of cancer progression. We're located at the Turku Bioscience Center in Turku, Finland! Find out more about us and our interests here: ivaskalab.utu.fi

Proud to be part of this cool story by @follainga.bsky.social, led by @guijacquemet.bsky.social and @johannaivaska.bsky.social.

Go and have a look!

Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers - The EMBO Journal The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these events under flow conditions. Here, we developed an i...

FlowVision:
@guijacquemet.bsky.social @johannaivaska.bsky.social et al describe a fast label-free live imaging approach revealing key principles of cancer cell arrest on endothelial monolayers–such as flow dynamics & CD44 interaction with matrix hyaluronic acid
link.springer.com/article/10.1...

Johanna Ivaska ja Jani Erola ovat Turun yliopiston uudet akatemiaprofessorit Suomen Akatemia on myöntänyt viisivuotisen akatemiaprofessorin rahoituksen InFlames-lippulaivan molekulaarisen solubiologian professori Johanna Ivaskalle ja Invest-lippulaivan sosiologian professor

Honoured and excited to launch this new RCF funded 2026-2031 project MechanoSpace with @ivaskalab.bsky.social. we will be hiring postdocs early next year www.utu.fi/fi/ajankohta...

The first September issue is live.

www.embopress.org/toc/14693178...

The cover features work by Cassie Clarke @cassiejclarke.bsky.social @cruk-si.bsky.social and co-workers showing that UPP1 supports #metastasis by altering #immune and ECM landscapes.

-> www.embopress.org/doi/full/10....

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…

Excited to share our most recent study on #integrintraffic #cancer #migration #focaladhesion by @ivaskalab.bsky.social @drpaulinamoreno.bsky.social Niklas Jäntti et al www.sciencedirect.com/science/arti...

Uusi koetin tekee näkyväksi syöpäsolun viestinnän, tutkijat voivat käyttää tietoa rintasyövän leviämisen estossa - InFLAMES-lippulaiva Turun yliopistossa ja Turun biotiedekeskuksessa toimiva tutkimusryhmä on kehittänyt tavan kuvata leviävien rintasyöpäsolujen soluviestintää. Menetelmä on paljastunut, että muihin syöpätyyppeihin parha...

Syövän nykyisillä lääkkeillä ei voida estää syövän leviämistä. Tilanne saattaa muuttua, sillä tutkijamme ovat kehittäneet tavan kuvata syöpäsolun sisäistä signalointia, joka on edellytys solun liikkumiselle.
#Illusia
@johannaivaska.bsky.social @ivaskalab.bsky.social @turkubioscience.bsky.social

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells Nature Cell Biology - Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST...

New paper in Nature Cell Biol from @johannaivaska.bsky.social and @ivaskalab.bsky.social

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells
rdcu.be/eoAUD

Uusi koetin tekee näkyväksi syöpäsolun viestinnän, tutkijat voivat käyttää tietoa rintasyövän leviämisen estossa Turun yliopistossa ja Turun biotiedekeskuksessa toimiva tutkimusryhmä on kehittänyt tavan kuvata leviävien rintasyöpäsolujen soluviestintää.

Miten syöpäsolut leviävät ja voidaanko sitä estää? Toistaiseksi ei, mutta tämä saattaa muuttua. Turun biotiedekeskuksen tutkijat löysivät keinon avata syöpäsolujen viestintää, ja tämän tiedon kautta saattaa löytyä lääke syöpäsolujen pysäyttämiseen.

@ivaskalab.bsky.social @johannaivaska.bsky.social

Ready to share our work as a poster at the upcoming Lorne Cancer Conference! Looking forward to discussing the role of integrin β1 in cancer invasion, and connecting with experts in the field. #LorneCancer2025

New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...

Our newest paper is out in NCB. @jrwconway.bsky.social‬ designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - Nature Cell Biology Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadop...

Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation!

Read more at:

www.nature.com/articles/s41...

Thanks for letting me participate! It was fun

Syöpätutkija Johanna Ivaskalle 100 000 euron tiedepalkinto Ivaskan työryhmä tutkii syöpäsolujen liikkumista ja leviämistä.

www.is.fi/kotimaa/art-...

Great recognition to @ivaskalab.bsky.social research at @turkubioscience.bsky.social the Finnish Science Prize
thanks to all my international friends and colleagues over the years

Finnish Science Award to Professor Johanna Ivaska The Finnish Science Award 2025 has been awarded to Johanna Ivaska, Professor of Molecular Cell Biology at the University of Turku.

Warm congratulations to our PI, Professor Johanna Ivaska👏💐🍾🎉🔥🔥🔥!
@johannaivaska.bsky.social @ivaskalab.bsky.social

Syöpätutkija Johanna Ivaska palkittiin 100 000 eurolla – ”Levinnyt syöpä on edelleen suuri haaste” Palkittu syöpätutkija kritisoi hallituksen säästöjä, jotka kohdistuvat yliopistojen perus­tutkimukseen.

yle.fi/a/74-20162747

Proud to have you in my team

Suomen tiedepalkinto turkulaiselle syöpätutkijalle Professori Johanna Ivaska pitää syöpää erityisen kiehtovana tutkimuskohteena ja innostuu siitä yhä uudelleen.

Paljon onnea Suomen tiedepalkinnosta, @johannaivaska.bsky.social
Professorin viesti päättäjille: "Minä toivoisin, että Suomen valtiovalta ja poliitikot ymmärtäisivät, että pienessä maassa perustutkimus on se ainoa tapa, millä niitä paljon puhuttuja innovaatioita saadaan."
www.ts.fi/uutiset/6665...

Kiitos

Tiedefoorumissa puhetta tieteestä. Onnittelut @johannaivaska.bsky.social Suomen tiedepalkinnosta.

Thanks this prize is really not for me but the @ivaskalab.bsky.social and all your hard work and brilliant brains