Rizzuto lab

This was so fun! Thank you so much to @cindyleifer.bsky.social and @microbetv.bsky.social for the opportunity to discuss pregnancy immunology ✨

I'm thrilled to share that the first paper from my PhD is out today in @cp-immunity.bsky.social!
Here, we investigated how phagocytes, such as macrophages, handle microplastics (MPs) during their normal functions.
www.sciencedirect.com/science/arti...

Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.

Out now: We present antibody-lectin chimeras (AbLecs) as a molecular platform to target sugars, or glycans, for cancer immunotherapy.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social

Congratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions

Scripps Research team identifies sugar molecules that trigger placental formation

Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.

“Rizz-ard of Oz: there’s no place like lab”
Happy Halloween! Thanks IGO for the annual party 🎃

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀

Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.

Sign up. Stay informed. Join the movement: www.nycures.org/

Cool logo! And cool science. :)

CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit Nature Cancer - Klebanoff and colleagues report that survival and persistence of CAR-T and CAR-NK cells are regulated by a FAS ligand–FAS autoregulatory circuit, showing that disabling FAS...

🚨Today, in #NatureCancer, we show that #CAR-T cells and #CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy. @mskcancercenter.bsky.social @parkerici.bsky.social

We are so proud of Mergim for passing his quals! Definitely warrants lollipops advertising his favorite model antigen.

Pregnancy irreversibly remodels the mouse intestine Researchers at the Francis Crick Institute have found that the small intestine grows in response to pregnancy in mice. This partially irreversible change may help mice support a pregnancy and prepare ...

Researchers at the Crick have found that pregnancy in mice leads to the irreversible growth of their small intestine.

www.crick.ac.uk/news/2025-03...

The Rizzuto lab

Exciting news! To welcome our new lab members from the past year and reaffirm our commitment to women’s health and pregnancy immunology, we’ve launched our lab website. Check it out- and if this fascinating niche in immunology speaks to you, let’s connect! www.therizzutolab.com

Way more fun with friends! I’m still waiting for you to discover what time is, though, friend … ⏰⏳♥️

It’s an incredible deep dive into a topic that was largely a mystery, with significant clinical implications for understanding pregnancy disorders!

(5/5)

KDM6B-dependent epigenetic programming of uterine fibroblasts in early pregnancy regulates parturition timing in mice Parturition timing in mice is controlled by locus-specific adjustment of histone H3 trimethyl lysine 27 (H3K27me3) levels within uterine fibroblasts in early gestation, with subsequent locus-specific ...

Whether or not you’re interested in repro bio, I urge you to check out my friend Tara’s graduate thesis work from the Erlebacher lab at UCSF, now published in Cell www.cell.com/cell/abstrac...

(4/5)

… but what events are upstream of this?

(3/5)

The field knows much about terminal events prior to labor induction(eg, COX-1–>prostaglandin)…

(2/5)

What determines the length of gestation? A short thread…

(1/5)