Eduardo Gushiken-Ibañez

Excited to share our lab’s latest preprint: In vivo single-cell CRISPR screening for microproteins identifies a critical ribosomal component.

Check out how we systematically explore #microprotein functions and how they expand the cellular proteome!

Huge thanks to all co-authors who contributed to this work — and especially to Giuseppe Ianiri, whose deep expertise in fungal genetics and generous collaboration were central to making this project a reality. Grateful to have worked together!

Malassezia is typically viewed as an opportunistic pathogen — but for the first time, we show evidence that it plays a mutualistic role in the skin.

The skin commensal yeast Malassezia promotes tissue homeostasis via the aryl hydrocarbon receptor As an abundant fungal colonizer of human skin, Malassezia has long been associated with pathological skin conditions, yet its role in skin homeostasis remain poorly understood. Here, we demonstrate th...

Our new preprint is out on @biorxivpreprint!
🔗 www.biorxiv.org/content/10.1...
This work done as part of my PhD at @lableibundgut.bsky.social
We show that the commensal fungus Malassezia promotes skin barrier function via AhR signaling, through secreted tryptophan-derived indoles.

Brain fog friendly version: why you should care about Regulatory T Cells (T regs) I wanted to share some info about the immune system, dysbiosis, and food intolerances that I think might be relevant to a lot of folks. Please note that there's still a lot of scientific debate about ...

"Ultimately, these changes lead to insufficient activation of a pathway controlled by the aryl hydrocarbon receptor (AHR)"

not to be that smug guy on the Internet but this is why I keep yelling about AhR and Regulatory T cells and immune conditions

liminalnest.wordpress.com/2024/05/28/b...

IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cells The crosstalk between immune and epithelial cells is vital to maintain intestinal homeostasis. Lebrusant-Fernandez et al. identify NKT cells in the small intestine as key regulators of epithelial biol...

Our first 🦋 post! Very happy to share our latest paper just out in Cell Reports, exploring the crosstalk between immune and epithelial cells in the gut. Check it out!
@vivianlilab.bsky.social @kingscollegelondon.bsky.social

www.cell.com/cell-reports...

Card9 and MyD88 differentially regulate Th17 immunity to the commensal yeast Malassezia in the murine skin The fungal community of the skin microbiome is dominated by a single genus, Malassezia. Besides its symbiotic lifestyle at the host interface, this co…

Check out our latest work on cutaneous immunity against Malassezia. Just out in Mucosal Immunology. Congrats to Meret Tuor and colleagues. Thanks to Mark Stappers, Neil Gow and Selinda Orr for your contributions. www.sciencedirect.com/science/arti...