Keshav K Singh, PhD

Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease A nutrigenomics framework identifies genetic diseases amenable to vitamin B2 and B3 therapies. This approach nominates vitamin B3 as a therapy for NAXD deficiency, a lethal neurodevelopmental disorder...

Last 2 weeks of literature on #Mitochondria in #Health & #Disease! 🤍 💚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social

Vit B2 and B3 nutrigenomics reveals a therapy for NAXD disease
www.cell.com/cell/fulltex...

Happy Holi from a Mitochondriac.
Every color adds its unique charm to the festival. Every mitochondrion contributes to a brighter, more energetic future.

I wish you all a Holi filled with boundless energy, happiness, and promising opportunities for all.

Rare Disease Day – 28 February 2026
Let’s unite to improve diagnosis and understanding of mitochondrial disease.

These rare conditions can affect any organ, at any age, impacting at least 1 in 4,000 people. Greater awareness and research are vital.

#RareDiseaseDay #MitochondrialDisease

A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity - Nature Metabolism The authors present a genetically encoded tool based on a bifunctional enzyme that can regenerate NAD+ while executing an engineered glycerol shunt. The tool successfully restored redox imbalance and ...

A wonderful collection of literature from #week8 on #Mitochondria in #Health & #Disease! 📚

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

A [...] bifunctional enzyme mitigates redox imbalance and lipotoxicity
www.nature.com/articles/s42...

Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species - Nature Metabolism Boosting mitochondrial metabolism in neurons in central memory circuits by enhancing Ca2+ retention in the mitochondrial matrix is shown to improve long-term memory formation in flies and mice.

Most recent collection of papers on #Mitochondria in #Health and #Disease!
#week7 #MitochondrialDisease 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
www.nature.com/articles/s42...

Forbes 250: America’s Greatest Innovators The Forbes Innovator 250: America's Greatest Innovators showcases the visionaries shaping our future. Find the full list of great minds and the mark they are leaving on our history.

www.forbes.com/sites/alexkn...

The next big thing in wellness is…mitochondria? People are suddenly very concerned about the powerhouse of the cell.

The next big thing in wellness is mitochondrial health.
www.vox.com/advice/47803...

Mitochondrial superoxide regulates nuclear envelope integrity and ageing via redox-mediated lipid metabolism - Nature Metabolism Mitochondrial superoxide production is shown to preserve nuclear envelope integrity by controlling lipid peroxidation, with impact on nuclear and organismal ageing in C. elegans.

A new collection of papers on #Mitochondria in #Health and #Disease! #MitochondrialDisease 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mt superoxide regulates nuclear integrity and ageing via lipid metab

www.nature.com/articles/s42...

Mitochondria painting - without the pain(t). Unvarnished mitochondrial biology, live, and at scale.

Entrepreneur of the month

How learning handwriting trains the brain: the science behind the cursive wars Handwriting requirements were cut from school curricula around the world. Now it’s looping back, riding on a wave of evidence.

I love this article!
When I was studying at NIH, Bethesda, I noticed that one elder lady secretary wrote beautiful handwritings, and we can enjoy that again!

How learning handwriting trains the brain: the science behind the cursive wars www.nature.com/articles/d41...

Both chambers of Congress have now passed the FY26 minibus with NIH provisions. The President will sign.

(1) $48.7 billion for NIH
(2) Full IDC recovery
(3) No more multi-year funding
(4) No NIH reorganization, maintaining the current IC structure.

Behind every successful entrepreneur is a mind that has battled pressure, doubt, and invisible wars.

A new collection of papers from #week5 on Mitochondria in Health & Disease! #MitochondrialDisease
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

Among highlights
www.nature.com/articles/s41...

https://academic.oup.com/nar/article/54/2/gkag008/8433879?login=false

A new collection of papers on Mitochondria in Health and Disease! #week3 #MitochondrialDisorders
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social

Human mitochondrial helicase Twinkle has RNA binding, annealing, and strand-exchange activities

Graphic helps visualize how MYF funds FEWER grants despite the increase in budget approval by Congress. https://www.researchamerica.org/wp-content/uploads/2025/11/ACT-for-NIH-Multi-Year-Funding-One-Pager_October-2025.pdf

🧪IMPORTANT! This graphic explains how science all over the US is funded. Congress approved a 2% increase in the #NIH budget for FY 26.

Buried in the bill-
Shift of ~40% of grants to MYF. This will still result in a 35% DECREASE in the NUMBER of grants funded per yr.

Russel Vought is behind this.

Honored to be recognized as one of the top 10 Startup companies to watch by Innovate Alabama

2026 Startups to Watch | Bill L. Harbert Institute for Innovation and Entrepreneurship share.google/UnTnl2cTLzui...

Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production - Nature Metabolism Hexokinase detachment from the outer mitochondrial membrane is shown to support aerobic glycolysis in cancer cells. Differential localization of the HK1 isoform to the outer mitochondrial membrane, co...

Latest collection of papers on mitochondria in health and disease! #MitochondrialDisease #week3

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

www.nature.com/articles/s42...

I asked AI to describe my contribution to the mitochondrial field. Received this. It's quite impressive and pretty accurate.

Excited to speak at the symposium “Artificial Intelligence in Mitochondrial Medicine”

🧬 Exploring how AI is transforming mitochondrial medicine
📍 Pisa, Italy | 🏨 Hotel Galilei
📅 Jan 23, 2026

#AIinMedicine #MitochondrialMedicine #DigitalHealth #PrecisionMedicine

Mitochondrial control of fuel switching via carnitine biosynthesis Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosynthe...

Last 2 weeks of research papers relevant to #MitochondrialDisease!
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mitochondrial control of fuel switching via carnitine biosynthesis
www.science.org/doi/10.1126/...

rebelcellskin.com

Post Image

NIH clarifies the difference between Highlighted Topics and Funding Opportunities. Misunderstanding the distinction can undermine…

https://www.ebhoward.com/how-to-understand-the-difference-between-nih-highlighted-topics-and-funding-opportunities/?utm_source=bluesky&utm_medium=jetpack_social

Recommendations for mitochondria transfer and transplantation nomenclature and characterization - Nature Metabolism This Consensus Statement provides a nomenclature framework and experimental recommendations for studying mitochondrial transfer and transplantation.

Reviews/Perspectives Top #Citations 2025: 🥇🧪

Jonathan Brestoff (Washington U Dept Med), Keshav Singh (@mitoscientist.bsky.social, U Alabama) et al.

Recommendations for mitochondria transfer and transplantation nomenclature and characterization

🌹🌹May all that is beautiful and meaningful and brings you and your family joy be yours throughout the coming year! Wish you a very happy new year!🌹🌹