A genetic therapy has reversed aggressive & incurable blood cancers in ~64% of patients in a trial.
The treatment involves editing the DNA in white blood cells to transform them into a cancer-fighting "living drug".
🧪🩸🧬 #medsky
www.bbc.co.uk/news/article...
#ASH25 Among patients with #ChronicLymphocyticLeukemia, fixed-duration targeted treatment using venetoclax-based combinations was found to achieve efficacy comparable to #BTKi therapy, with 3-year PFS ranging from 79% to 81% across all treatment arms: https://ow.ly/LOkJ50XExRg
#HemeSky #OncSky
Excellent Review!!
Immune alterations in myeloma evolution and outcomes: quo vadis? buff.ly/6ft0xTG #hemesky
A graph showing the longitudinal variant allele frequency determined by whole-genome sequencing from the stem-cell product, peripheral-blood mononuclear cells (PBMC) before CAR T-cell therapy, and isolated peripheral-blood tumor cells
A rare T-cell lymphoma after chimeric antigen receptor (CAR) T-cell therapy for myeloma was linked to CCR4 overexpression and vector integration, which highlights the need for monitoring after CAR T-cell therapy. Read the full case details: nej.md/41fYX4v
#MedSky #Hematology #Genetics
In-vivo B-cell maturation antigen CAR T-cell therapy for relapsed or refractory multiple myeloma - The Lancet www.thelancet.com/journals/lan...
Antibiotic use: impact on the microbiome and cellular therapy outcomes
buff.ly/Awz7wZU #hemesky
In this 60-Second Journal Club, NEJM Editorial Fellow Abarna Pearl, MD, MPH, summarizes the BALANCE trial comparing antibiotic treatment for 7 versus 14 days in patients with bloodstream infections. Read the full article and accompanying Research Summary: nej.md/3Z5bTJD
#MedSky #IDSky
Perforin is responsible for creating a channel/pore (punching a hole) between cytolytic lymphocytes, natural killer cells and CD8 T cells, and their target cells, allowing for the delivery of apoptosis-inducing granzyme proteins. buff.ly/YFitped #hemesky
No doubts #EHA is the best congress of hematology ever.
EHA Highlights: First-in-Human Study of Trispecific Antibody JNJ-5322 Shows Promising Activity in Relapsed/Refractory Multiple Myeloma
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #EHA #EHA2025 #MM #RRMM
Risk of SMN Low After CAR-T Therapy: The risk of secondary #myeloid #neoplasms (SMNs) following #CD19 #CARTcell therapy may be lower than expected. According to a retrospective study, SMNs occurred in 2.5% of patients after treatment with CAR T-cell therapy.
#HemeSky
For patients undergoing CD19-directed #CARTcell therapy, #itacitinib prophylaxis effectively reduced the incidence and severity of #cytokine release syndrome (CRS), with just 17.4% of patients experiencing grade ≥2 CRS compared with 56.5% on placebo: ow.ly/9y5l50W4mYU
#HemeSky #MedSky
Results from an MD Anderson study identified three subgroups of patients with large B-cell lymphoma who have different levels of benefit from CD19 CAR T cell therapy.
How the findings offer insights on the best potential clinical pathways: spr.ly/60174rfXF #EndCancer
A recent meta-analysis in JAMA Network Open evaluated cardiovascular risks in 1,528 adults receiving CAR T-cell therapy for advanced blood cancers.
@jama.com
#Onco404 #Cancer #Kanser #Hematology #CardioOncology #CARTCellTherapy #MetaAnalysis #MedResearch #MedSky #OncSky
There are so many ways to rev up our immune response against cancer. Here, the oncolytic viruses
www.cell.com/cancer-cell/...
The New England Journal of Medicine Antibiotic Treatment for 7 or 14 Days for Bloodstream Infection A Research Summary based on The BALANCE Investigators | 10.1056/NEJMoa2404991 | Published on November 20, 2024 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.
In the BALANCE trial, patients with bacteremia were assigned to 7 or 14 days of appropriate antimicrobial therapy, and 7 days of therapy was found to be noninferior to 14 days. Full trial results and Research Summary: nej.md/3Z5bTJD
#MedSky #CriticalCare #IDSky
TB drug targets
Today is World TB day. Here's a recent comprehensive review on therapeutic developments for tuberculosis and nontuberculous mycobacterial lung disease
www.nature.com/articles/s41...
rdcu.be/eeQ0m
The Pharmaceutical approach of obesity in children is a complete mistake, terrible results in a multi factorial disease.
Come together, really hard times for the science. | Science www.science.org/doi/10.1126/...
Restoration of the #immune function as a complementary strategy to treat #CLL effectively. This approach aims to achieve dual disease control by targeting both malignant B-cell activity and the often-compromised immune system in #CLL patients.
Eggs?
Table. Stem Cell Donation Process and Short-Term Adverse Effects of Stem Cell Donation
Hematopoietic stem cell transplant is a critical treatment for various cancers and other conditions.
This JAMA Insights discusses the process of allogeneic stem cell donation, including donor selection, preparation, and potential risks and benefits.
ja.ma/40911K8
Cytomegalovirus (CMV) is the leading cause of infectious birth defects and linked to many other morbidities such as with transplantation. For the first time after >50 years of pursuit, a vaccine is in reach jci.org/articles/vie...
Del gran Bukowski "No leaders please" Esto de las fechas "especiales" si tienen algo de bueno (probablemente lo único) es que son recordatorio de gratitud, reflexión, y sobre todo, de re invención a diferentes niveles, al no tenerlo en cuenta todo pierde sentido...
youtu.be/PLauo0Qx48k?...
Excelente
Un documental desgarrador, extraordinario #NoOtherLand. Siempre en @filmin.es
Ayuso es todo lo malo que te puedas imaginar, todo.
Whooping cough
La contaminación mata. #AirPollution
