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We found that the proteins Nono and SFPQ assemble into long filaments. Curious to know whether these filaments also exist in paraspeckles.
Very enjoyable collaboration with Dietmar Geiger at @uni-wuerzburg.de . We used #cryoEM for structure determination rdcu.be/e06t7 .
Filament formation of full-length NONO/SFPQ heterodimers and in vitro structural characterization may provide a scaffold for gene regulation, paraspeckle formation and DNA double-strand break repair in vivo. @boettchercryoem.bsky.social
New article available at www.nature.com/articles/s42...
We mourn the passing of Peer Bork, EMBO Member since 2000: https://www.embl.org/news/embl-announcements/in-remembrance-of-peer-bork/
Very cool work by the Schindelin Lab@en-hxnu-enment.bsky.social @uni-wuerzburg.de. Very excited to see this preprint. Happy to have contribute some #cryoEM
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Erice Structural Biology Course 2026 (29 May–6 Jun): apply! Train in Cryo-EM, Cryo-ET & ML to study macromolecular assemblies in cells. Hands-on + theory for next-gen structural cell biology.
🔗 erice2026.azuleon.org/application....
#CryoEM #CryoET #MachineLearning #StructuralBiology #CellBiology
YnaI in the open and closed state
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We were very surprised to find out that the MscS-like channel YnaI does not tilt its paddle helices to open.... almost overlooked the huge pore in our cryo-EM maps
Very proud that this is finally out: rdcu.be/eB3FF
Well done, Vanessa @uni-wuerzburg.de
SLC26A11 is an atypical solute carrier with dual transport-channel function mediating lysosomal sulfate transport https://www.biorxiv.org/content/10.1101/2025.08.17.670773v1
🎉 Congratulations to @angelifriedmann.bsky.social on receiving an @erc.europa.eu Proof of Concept grant! With his project “SulFex”, he is working on a new strategy for treating a specific form of lung cancer #ERCPoC 📷Andreas Heddergott go.uniwue.de/poc-grant-an...
Structure of lymphostatin, a large multi-functional virulence factor of pathogenic Escherichia coli pubmed.ncbi.nlm.nih.gov/40562750/ #cryoEM
Our paper on Lymphostatin is now out (rdcu.be/etk2v). It shows #cryoEM structures of this huge virulence factor revealing amazing domain reorganisations.
Very enjoyable collaborating with the Stevens Lab in Edinburgh and the Boersch Lab in Jena to see how it gets into cells.
@uni-wuerzburg.de 🧪❄️
Very happy that this is now out. Cool collaboration with Weikert and Gmeiner group
#cryoem #gpcrs 🧪 @uni-wuerzburg.de @fau.de
Deutschlandkarte der Verteilung der Exzellenzcluster auf Bundesländer und Universitäten.
Die #Exzellenzcluster stehen fest: Heute hat die Exzellenzkommission 70 Projekte zur Förderung ausgewählt. 45 Cluster werden fortgesetzt, 25 neu eingerichtet. Die Förderung beginnt ab 1. Jan. 2026 für 7 Jahre, die Fördersumme beträgt insg. 539 Mio. €/Jahr. Die Liste: www.dfg.de/resource/blo... 1/3
Etwa 150 Personen folgten dem Aufruf zum Flashmob. (Bild: Jochen Kuper)
Die Uni Würzburg unterstützt die Petition "Geht wählen – mit Verstand: #Demokratie braucht #Fakten"
Heute fand dazu ein Flashmob am RVZ statt - und 150 Personen folgten dem Ruf.
🗣️"Nur eine demokratische Gesellschaft schützt Forschungs- und Meinungsfreiheit", so Organisator Prof. Manfred Gessler.
Our joined effort with the the Maric Lab @hmariclab.bsky.social @uniwuerzburg.bsky.social on how to aggregate capsids of Hepatitis B virus inside cells is now out in Elife doi.org/10.7554/eLif... . #cryoEM 🧪❄️🔬
