Paper out now in @natbiotech.nature.com by @yizhoudonglab.bsky.social describing new LNP mRNAs for combatting bacterial infections… helping the immune system clear the pathogens while limiting tissue damage…
Congratulations to Yonger Xue & Xucheng Hou for leading the wonderful work on peptibody mRNA! Thanks @miriammerad.bsky.social for the huge support! Thanks Rong Li @natbiotech.nature.com and reviewers for the amazing review process! Thanks @NIH @IcahnMountSinai!
Chemical strategies for brain delivery of genomic therapy, a very nice Perspective with @ericjnestler.bsky.social! Congratulations to Haoyuan, Changyue, and Tami! Thanks Nature Reviews Chemistry! Thanks NIH& @mountsinainyc.bsky.social!
www.nature.com/articles/s41...
rdcu.be/eRKLA
NOT TO MISS! In @mountsinainyc.bsky.social's 2025 issue of Science & Medicine magazine, Dean @ericjnestler.bsky.social discusses his vision for Icahn Mount Sinai, and how his distinguished academic career & research expertise have prepared him. 👉 scienceandmedicine.mountsinai.org/article/2025...
Comment of the day on the petition calling for a funding institute to elevate biomedical research across New York State! Sign & share!
The 2025 issue of @mountsinainyc.bsky.social's Science & Medicine magazine is now live! At this pivotal moment for health care, Mount Sinai fearlessly embraces its leadership role in medical education, scientific research & patient-centered clinical care. READ👉 scienceandmedicine.mountsinai.org/2025
📢 SIGN & SHARE THE PETITION! 📢
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
A Special Congratulations to @ericjnestler.bsky.social on receiving the 2025 Synapsy Prize. This prestigious award celebrates lifelong dedication to translating fundamental neuroscience discoveries into tangible clinical advancements in mental health. Learn More 👉 www.eurekalert.org/news-release...
We ❤️❤️❤️ New York State — but life here could be fairer and healthier for all. If you agree, sign up at www.nycures.org!
💔 Over 154,000 NYC public school students experienced houselessness last year. @sunyofficial.bsky.social estimates 8% of undergrads and 5% of grad students face housing insecurity.
Our latest work @mitkochinstitute.bsky.social is now published in @natnano.nature.com ! By optimizing lipid nanoparticle design, we significantly improved #mRNA expression and immune responses — paving the way for a new class of delivery systems for #vaccine.
Free access - rdcu.be/eOLjb
#biotech
🧬 mRNA has emerged as a powerful new class of therapeutic molecules—extending far beyond vaccines to cancer immunotherapy, protein replacement, and gene editing.
🧩 But designing mRNAs with strong, lasting protein expression remains a major challenge.
In @natchembio.nature.com, @yizhoudonglab.bsky.social highlights GEMORNA, an AI framework that directly generates mRNA & circRNA sequences by jointly modeling CDSs & UTRs, for coordinated optimization of expression and stability.
An elegant tool to help design mRNAs!
www.nature.com/articles/s41...
For readers interested in lipid nanoparticles for nucleic acid delivery, here's a perspective by Cullis and Feldner on the evolution of the field
rdcu.be/eMpeO
nature.com/articles/s41...
"The way forward has become very clear"- Dr. Brendan G. Carr
A HUGE CONGRATULATIONS to @ericjnestler.bsky.social named Anne & Joel Ehrenkranz Dean of the Icahn School of Medicine. We’re thrilled about the exciting new direction Icahn Mount Sinai will take under Dr. Nestler's visionary leadership!
With co-authors Bram Teunissen & @yizhoudonglab.bsky.social, we dive into emerging ways to make LNPs more precise—from tuning their chemistry to reprogramming RNA expression and even controlling protein stability & localization >>> a road🗺️ for more intelligent delivery & broader applications ahead.
The BIGGEST impact you can have with 1 minute today ⏱️
Add your name to show NY is ready for a statewide biomedical institute.
CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York.
✍️ www.nycures.org/
🚨 AIMBE calls on the scientific community to urge Congress to ensure timely passage of the FY2026 budget 👇
Strong, sustained funding for our nation's health and science agencies is essential for economic prosperity, U.S. global competitiveness, and public heath.
takeaction.io/aimbe/protec...
PRESS RELEASE! @mountsinainyc.bsky.social receives $8 million grant from DataPhilanthropy to fuel research into #CADASIL This transformational grant will launch new Center led by Dr @fanny-elahi.bsky.social to pursue trtmnts for understudied neurovascular diseases👉 www.mountsinai.org/about/newsro...
📝NEW STUDY📝 Cancer's first punch when battling the immune system may be rewiring myeloid progenitors in bone marrow so they become suppressive tumor macrophages blunting T-cell attacks. Find out how in @nature.com from @samhegde.bsky.social & @miriammerad.bsky.social 🧐 www.nature.com/articles/s41...
💫Through the #SURP4US program, under the mentorship of
@yizhoudonglab.bsky.social, Alister (Jia) Ng gained research experience & developed an interest in drug design & delivery. Inspired by her family's history w/ #Antidepressants; she aspires to pursue a career in pharmaceutical research.
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
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🚨 Out now in @nature.com: it's time to de-Americanize global science. We need:🌍 Equitable funding 🔄 Shared governance 🔐 Resilient data infra🆘 Emergency support for scientists at risk. The next crisis can’t break global research again. Nova Medical School
🔗 rdcu.be/ewp6K
Chemical modifications of RNA
RNA chemistry and therapeutics www.nature.com/articles/s41...
rdcu.be/ewkq0
This new Review covers synthetic methods applied to RNA therapeutics in multiple classes and chemical modification strategies being used to enhance their properties
@yizhoudonglab.bsky.social
Misinformation is winning not because it's true, but because it’s loud, emotional, and everywhere.
It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇
📖 www.nature.com/articles/s41...
#SciComm @sinaiimmuno.bsky.social @aspeninstitute.bsky.social
ONLINE NOW! Neurosurgery & Neurology Special Report 2025.
In this issue, Check Out "Mount Sinai Is Among First to Use Blood Tests as Early Detection Tool for #AlzheimersDisease and Related #Dementias in Patients". @fanny-elahi.bsky.social Learn More 👉 reports.mountsinai.org/article/neur...
We have updated our database of funding opportunities for Early-Career Researchers (private foundations, federal, international)
We have 456 entries, for which we provide $ amount, deadline, eligibility criteria, etc.
Download this massive database here for free: research.jhu.edu/rdt/funding-...
Evolution-guided protein design of IscB for persistent epigenome editing in vivo - @zhangf.bsky.social @broadinstitute.org @hhmi.org go.nature.com/44XVBph
FRIDAY👉May 9, 2pm, DON'T MISS this #FriedmanBrainInstitute Special Seminar as hosts
@ericjnestler.bsky.social & @fanny-elahi.bsky.social welcome @institutducerveau.bsky.social's Dr. Stéphanie Debette. LEARN about cutting edge research on #vascular disease & #VCID #CSVD done at Paris Brain Institute.
PRESS RELEASE | Mount Sinai researchers Arthur Godino, Marine Salery, @ericjnestler.bsky.social, et al. have discovered distinct roles for 2 dopamine receptors located on nerve cells w/in the portion of the brain that controls approach vs avoidance behavior. www.mountsinai.org/about/newsro...
