So great to have had the opportunity to present my work!
Thank you #VIINYIS !
26.11.2025 23:19
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So great to have had the opportunity to present my work!
Thank you #VIINYIS !
Great talk from @ludivine-grzelak.bsky.social from @thedohertyinst.bsky.social on "Revealing dose and repeat effects of a novel Influenza vaccine on humoral immunity".
Always excited when flu vaccine research moves ahead. More of this, please! ππ
#YoungVIIN2025 #VIINYIS
Huge thanks to my co-first author Carolyn Cohen from HKU Pasteur, my supervisor Sophie Valkenburg, all our collaborators from Hong Kong University and the participants who made this study possible!
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Importantly, this suggests that children may generate a highly targeted and functional immune responseβde novo, rather than relying on cross-reactive memory from other coronaviruses.
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Children also have enhanced FcΞ³ receptor (FcΞ³R) binding, compared to adults β suggesting that their immune responses may be more functionally effective in targeting the virus.
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We explored how the humoral immune response to SARS-CoV-2 differs between children and adults. Despite having lower overall antibody levels, children were shown to generate antibodies with higher avidity for the full Spike and Nucleocapsid proteins.
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π Thrilled to share our newest paper and my first one in the Valkenburg lab @thedohertyinst.bsky.social published in @natcomms.nature.com:
SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults
doi.org/10.1038/s414...
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